Dr. Gwen Randolph

The dynamics of inflammation and organ immunophysiology: minding the outbound traffic

Abstract

The organization of mammalian anatomy is designed to selectively facilitate interorgan communication, while limiting spread of overt inflammatory or infectious signals. This seminar will present an overview of the Randolph laboratory’s past and ongoing work in delineating mechanisms that govern dissemination of immune cells (particularly monocytes, macrophages, dendritic cells) and molecules (particularly HDL-type lipoproteins) out of organs through the lymphatic and venous vasculature for the control of immune and inflammatory homeostasis. The interplay of these mechanisms with chronic inflammatory diseases will be discussed.

This event is part of the Morgridge Metabolism Colloquium.