Peter Crawford, PhD, Professor, Departments of Medicine, and Biochemistry, Molecular Biology, and Biophysics, University of Minnesota
Seminar Title: Protective interorgan, intercellular, and intercompartmental metabolite shuttles in obesity
Our group is committed to understanding the metabolic origins of both wellness and disease, particularly those rooted in overnutrition and maladaptive energy economy. We leverage recent analytical chemical and computational advances in high-resolution mass spectrometry and magnetic resonance spectroscopy to perform both static and stable isotope tracing targeted and untargeted metabolomics, as well as formal quantifications of metabolic fate and flux. I will present a recent set of observations through which our group examined novel predictive relationships between discrete members of the insulin-sensitizing fatty acid-hydroxy fatty acid (FAHFA) class of lipokines to cardiorespiratory fitness in lean versus overweight human participants. In addition, much of our work has proceeded through dissection of integrated ketone body metabolism in obesity, nonalcoholic fatty liver disease progression, and congestive heart failure. Advanced physiological phenotyping methodologies are strategically aligned with chemical profiling platforms to generate resolved phenotypic pictures in genetically manipulated mouse models and in human participants. Evidence will be provided that the spillover ketone metabolic pathway can play a key role in maintaining metabolic health even in carbohydrate-laden states.