Biomedical Imaging

Huisken Lab

Creating tailor-made optical microscopes to non-invasively explore morphogenesis and function in living organisms.

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We specialize in developing light sheet microscopy, a novel fluorescent imaging technique, to study the early development of several major modal organisms. The technique gently images fast biological processes that are extremely sensitive. Focused on the zebrafish, we are interested in the investigation of its organogenesis with special emphasis on the function and morphogenesis of the cardiovascular system and the endoderm.

We believe that multi-disciplinary approaches are required to tackle questions in modern life sciences. With our background in biology, physics, microscopy, and informatics we develop custom optical imaging, manipulation, and image analysis tools to pursue research in the broad field of embryonic organ morphogenesis. We strive for a comprehensive solution by developing and optimizing all aspects of modern optical imaging from sample preparation to image analysis.

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Principal Investigator Jan Huisken

The overall goal of my lab is the systematic study of developmental processes in living organisms by noninvasive biomedical imaging techniques such as optical microscopy. Of primary interest is the investigation of organogenesis in zebrafish with special emphasis on the function and morphogenesis of the cardiovascular system and the endoderm. We develop novel quantitative microscopy tools and experimental strategies to understand and describe tissue dynamics on a cellular level. High-speed fluorescence microscopy is the primary tool to capture the dynamics of a heartbeat and the fate of single cells during organogenesis.

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