Alex Walsh

Assistant Scientist

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My research focuses on the development and use of functional imaging technologies for improved understanding of physiological phenomena and translation for patient benefit. Optical metabolic imaging allows non-contact, quantitative measurements of cellular metabolism for assessing immune cell function and drug response of tumors.

Education

Ph.D. May 2015 Vanderbilt University
M.S. May 2012 Vanderbilt University
B.E. May 2010 Vanderbilt University

Publications

  • Walsh AJ, Cook RS, Skala MC, “Functional Optical Imaging of Primary Human Tumor Organoids: Development of a Personalized Drug Screen,” Journal of Nuclear Medicine, 2017.
  • Walsh AJ, Tolstykh GP, Martens S, Ibey BL, Beier HT, “Action potential block in neurons by infrared light,” Neurophotonics, 2016; 3(4):040501.
  • Walsh AJ, Castellanos J, Nagathihalli N, Merchant N, Skala MC, “Optical imaging of drug-induced metabolism changes in murine and human pancreatic cancer organoids reveals heterogeneous drug response.” Pancreas, 2016; 45(6): 863-869.
  • Walsh AJ, Cook RS, Sanders ME, Arteaga CL, Skala MC, “Drug response in organoids generated from frozen primary tumor tissues” Scientific Reports, 2016; 6: 18889.
  • Walsh AJ, Cook RS, Lee JH, Arteaga CL, Skala MC, “Collagen density and alignment of responsive and resistant trastuzumab-treated breast cancer xenografts” Journal of Biomedical Optics, 2015; 20(2): 026004.
  • Walsh AJ, Skala MC, “Optical metabolic imaging quantifies heterogeneous cell populations,” Biomedical Optics Express, 2015; 6(2):559-573.
  • Walsh AJ, Cook RS, Sanders ME, Arteaga CL, Skala MC, “Quantitative optical imaging of primary tumor organoid metabolism predicts drug response in breast cancer” Cancer Research, 2014; 74(18): 5184-5194.
  • Walsh AJ, Cook RS, Manning HC, Hicks DJ, Lafontant A, Arteaga CL, Skala MC. “Optical imaging identifies breast cancer glycolytic levels, subtypes, and early treatment response.” Cancer Research. 2013; 73(20):6164-74.