Alex Walsh

Assistant Scientist



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My research focuses on the development and use of functional imaging technologies for improved understanding of physiological phenomena and translation for patient benefit. Optical metabolic imaging allows non-contact, quantitative measurements of cellular metabolism for assessing immune cell function and drug response of tumors.


Ph.D. May 2015 Vanderbilt University
M.S. May 2012 Vanderbilt University
B.E. May 2010 Vanderbilt University


  • Walsh AJ, Cook RS, Skala MC, “Functional Optical Imaging of Primary Human Tumor Organoids: Development of a Personalized Drug Screen,” Journal of Nuclear Medicine, 2017.
  • Walsh AJ, Tolstykh GP, Martens S, Ibey BL, Beier HT, “Action potential block in neurons by infrared light,” Neurophotonics, 2016; 3(4):040501.
  • Walsh AJ, Castellanos J, Nagathihalli N, Merchant N, Skala MC, “Optical imaging of drug-induced metabolism changes in murine and human pancreatic cancer organoids reveals heterogeneous drug response.” Pancreas, 2016; 45(6): 863-869.
  • Walsh AJ, Cook RS, Sanders ME, Arteaga CL, Skala MC, “Drug response in organoids generated from frozen primary tumor tissues” Scientific Reports, 2016; 6: 18889.
  • Walsh AJ, Cook RS, Lee JH, Arteaga CL, Skala MC, “Collagen density and alignment of responsive and resistant trastuzumab-treated breast cancer xenografts” Journal of Biomedical Optics, 2015; 20(2): 026004.
  • Walsh AJ, Skala MC, “Optical metabolic imaging quantifies heterogeneous cell populations,” Biomedical Optics Express, 2015; 6(2):559-573.
  • Walsh AJ, Cook RS, Sanders ME, Arteaga CL, Skala MC, “Quantitative optical imaging of primary tumor organoid metabolism predicts drug response in breast cancer” Cancer Research, 2014; 74(18): 5184-5194.
  • Walsh AJ, Cook RS, Manning HC, Hicks DJ, Lafontant A, Arteaga CL, Skala MC. “Optical imaging identifies breast cancer glycolytic levels, subtypes, and early treatment response.” Cancer Research. 2013; 73(20):6164-74.