Reza Djavadian

Postdoctoral Fellow

Area:

Phone:

(608) 265-9740

Email:

[javascript protected email address]

Positive-strand RNA viruses constitute many clinically relevant pathogens, including Hepatitis C, SARS, zika-, Dengue, and poliovirus. A common feature of this group of viruses is that, upon infection, the first proteins expressed restructure the host intracellular membranes to from viral replication compartments. I am specifically interested in studying the structural features of these multifunctional proteins. Because these proteins are highly conserved among positive-strand RNA viruses, this approach has potential to identify novel targets for the design of broad-spectrum antivirals.

Education

B.S., 2010, Chemistry, University of Michigan – Ann Arbor
Ph.D., 2018, Cancer Biology, University of Wisconsin – Madison

Publications

  • Romero-Masters JC, Ohashi M, Djavadian R, Eichelberg MR, Hayes M, Bristol JA, Ma S, Ranheim EA, Gumperz, J, Johannsen EC, Kenney SC.
    An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model – PLoS Pathog. 2018 Aug 20;14(8):e1007221. doi: 10.1371/journal.ppat.1007221.
  • Bristol JA, Djavadian R, Albright ER, Coleman CB, Ohashi M, Hayes M, Romero-Masters JC, Barlow EA, Farrell PJ, Rochford R, Kalejta RF, Johannsen EC, Kenney SC.
    A Cancer-Associated Epstein-Barr Virus BZLF1 Promoter Variant Enhances Lytic Infection – PLoS Pathog. 2018 Jul 27;14(7):e1007179.doi:10.1371/journal.ppat.1007179
  • Djavadian R. Hayes M. Johannsen E.
    CAGE-seq Analysis of Epstein-Barr Virus Lytic Gene Transcription: 3 Kinetic Classes from 2 Mechanisms – PLoS Pathog. 2018 Jun 4;14(6):e1007114. doi:10.1371/journal.ppat.1007114
  • Price AM, Dai J, Bazot Q, Patel L, Nikitin PA, Djavadian R, Winter PS, Salinas CA, Barry AP, Wood KC, Johannsen EC, Letai A, Allday MJ, Luftig MA.
    Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection. Elife. 2017 April 20;6. pii: e22509. doi: 10.7554/eLife.22509
  • Nawandar DM, Ohashi M, Djavadian R, Barlow E, Makielski K, Ali A, Lee D, Lambert PF, Johannsen E, Kenney SC.
    Differentiation-Dependent LMP1 Expression is Required for Efficient Lytic Epstein-Barr Virus Reactivation in Epithelial Cells. J Virol. 2017 Mar 29;91(8). pii: e02438-16. doi: 10.1128/JVI.02438-16
  • Djavadian R, Chiu Y-F, Johannsen E.
    An Epstein-Barr Virus-Encoded Protein Complex Requires an Origin of Lytic Replication In Cis to Mediate Late Gene Transcription. PLoS Pathog. 2016;12: e1005718. doi:10.1371/journal.ppat.1005718