The proper specification and differentiation of germ cells ensure the continuity of all sexually reproducing species. Studies across a wide range of organisms have revealed key, conserved features in germ cell development, including the importance of localized niches and somatically derived systemic cues. Planarian flatworms are well known for their remarkable regenerative capabilities and can even regenerate new germ cells from fragments of adult tissue that lack reproductive organs. This amazing plasticity is derived from pluripotent stem cells that planarians maintain throughout life. By leveraging the planarian S. mediterranea as a model organism, we aim to gain deeper insights into the critical signals that regulate germ cell specification, development, and regeneration. Our research also extends to the study of parasitic flatworms with the goal of developing new strategies to control these parasites, which impact millions of people globally.
Education
BS, Biology, University of Virginia
PhD, Biochemistry, Cellular, and Molecular Biology, Johns Hopkins University School of Medicine