News & Stories - Morgridge Institute for Research

News & Stories

2022-2023 Morgridge Ethics Cartooning Competition – Public Voting

Eighteen cartoons have been selected as finalists in the 2023 Ethics Cartooning Competition, an annual contest sponsored by the Morgridge Institute. Learn more

2022-2023 Morgridge Ethics Cartooning Competition – Public Voting

Eighteen cartoons have been selected as finalists in the 2023 Ethics Cartooning Competition, an annual contest sponsored by the Morgridge Institute.
CAR macrophages show promise for cancer immunotherapy treatments

Scientists use stem cells to develop CAR macrophages that can infiltrate and kill tumor cells, showing promise for cancer immunotherapy treatments.
Photos: How Sea Spiders and Other Creatures Could Unlock the Secrets of Tissue Regeneration

via Wall Street Journal

Many animals have the ability to regrow limbs and other body parts after injury. A Wall Street Journal photo essay explores scientific inquiries into these amazing creatures — including the work of Melanie Issigonis in the Phil Newmark Lab at Morgridge.
Stunningly detailed blueprint revealed of viral genome replication machinery

Morgridge virologists have outlined in atomic detail the intricate RNA replication machines that coronaviruses create inside infected cells, giving rise to potential new strategies to fight disease.
Mass spec fueling new explorations at the Carbone Cancer Center

Every cell has about 20,000 proteins, several hundred metabolites, and couple of thousand lipids. When those things get perturbed, bad things can happen. But measuring those changes may offer essential clues for fighting cancer.
New faculty profile: Daniela Drummond-Barbosa explores physiological regulation of stem cell lineages

via College of Agricultural and Life Sciences

Daniela Drummond-Barbosa joined the UW–Madison faculty in September 2022 as a professor in the Department of Genetics.
From ‘blobology’ to atomic precision: Wisconsin’s leadership on cryo-EM imaging

Wisconsin is now an established national leader in cryo-electron microscopy, or cryo-EM, thanks to a decade-long strategic push from the UW-Madison biochemistry department and the Morgridge Institute.
High-throughput computing: Fostering data science without limits

HTCondor is gaining adherents across UW because scientists are learning that it is more than someone asking, “What technology do you need?” Research computing is a collaboration, and the people HTC brings to the equation are more important than the technology.
Genome Spotlight: Nile Rat (Avicanthis niloticus)

via The Scientist

Common rodent models aren’t ideal for studying certain diseases, but the Nile rat might offer a solution. A high-quality reference genome for the species will aid studies on type 2 diabetes and circadian rhythm disruption.
Metabolism research has morphed from mundane to essential

At a meeting of the Wisconsin Tech Council, Morgridge scientists described the renaissance taking place in metabolism research, which is revealing newfound connections to disease and entirely new roads to treatment and prevention.
UW–Madison Faculty Make Strong Showing on Global Highly Cited Researchers List

via UW-Madison

Morgridge investigator Kevin Eliceiri is one of 16 UW-Madison researchers to make the 2022 list of “Highly Cited Researchers,” compiled annually by the Office of Scientific Information.
Skala named inaugural Carol Skornicka Chair

Melissa Skala, an investigator in biomedical imaging and professor of biomedical engineering, has been named the inaugural Carol Skornicka Chair at the institute.
The Morgridge Metabolism Initiative: A blueprint for collaboration

The Morgridge Metabolism Initiative helps hundreds of campus scientists learn from each other and push the boundaries of research that is central to human health questions such as aging, diabetes and cancer.
Genome sequencing supports Nile rat animal model for diabetes research

For the first time, researchers have assembled a high-quality reference genome for the Nile rat, a promising model organism for diabetes research.
Meet The Lab inspires students with Morgridge Institute research

Classrooms from Wisconsin and beyond explore Morgridge science through new Meet the Lab resources from PBS Wisconsin.
CZI Science Diversity Leadership Award Grantees

via Chan Zuckerberg Initiative

CZI partnered with the National Academies of Sciences, Engineering, and Medicine to launch the Science Diversity Leadership program, a funding opportunity that aims to recognize and further the leadership of excellent biomedical researchers who — through their outreach, mentoring, teaching, and leadership — have a record of promoting diversity, equity and inclusion in their scientific fields.
Best of the Fest: 2022 Wisconsin Science Festival in photos

We’ve collected some of our favorite moments from the 2022 Wisconsin Science Festival, which boasted a full week of over 300 events statewide.
Honoring Carl Gulbrandsen: a visionary champion for Wisconsin innovation

Carl Gulbrandsen was a visionary leader whose service to Wisconsin innovation left a lasting impact at Morgridge, WARF, and UW-Madison.
Developing the science of science communication

The Morgridge Institute and UW-Madison Life Sciences Communication will join forces to investigate new ways to best communicate complex scientific topics to society.
Solving for the future: Investment, new coalition levels up research computing infrastructure at UW–Madison

via UW-Madison Information Technology

Bolstered by a $4.3 million investment from the Wisconsin Alumni Research Foundation, UW–Madison’s research computing hardware is getting a significant upgrade—giving researchers the sustained shared infrastructure they need to help them push the bounds of science with support from the Morgridge Institute.
Empowering early career professionals on the importance of diversity

At the 2022 Emerging Leaders Symposium, a group of professionals and panelists shared ideas about shaping the future of academia and the medical sciences through diverse perspectives and nurturing young talent.
Desa named inaugural Melita F. Grunow Postdoctoral Fellow

Danielle Desa seeks to break ground in imaging design and stem cell research with support from the new Melita F. Grunow Postdoctoral Fellowship. She is mentored by Morgridge Investigator Melissa Skala and Biomedical Engineering Professor William Murphy.
How COVID-19 shaped the evolution of a collaborative manuscript writing tool

The COVID-19 pandemic and our tech-driven world have highlighted the need for accessibility of research and efficiency of science publishing. Manubot is one tool that could change the game.
Unleash your curiosity at the 12th annual Wisconsin Science Festival!

From glass blowing to space exploration, the Wisconsin Science Festival, held October 10-16, will feature over 300 in-person and virtual events throughout the state.
Training the next generation of science leaders at Morgridge

Scientific training is much more than learning experimental methods or interpreting data. Trainees must practice management, leadership, collaboration, and communication skills to be successful and the Morgridge Institute is committed to fostering growth of “whole scientists” who are prepared to lead.
Stem cell research uncovers clues to unique evolution in planarian reproduction

A new stem cell study describes genetic factors that support the development of germ cells and yolk cells in the reproductive organs of planarian flatworms.
A research partnership brings gene editing promise to eye disease

One of the first frontiers of CRISPR gene editing is targeting diseases related to the eye. A diverse Morgridge and UW-Madison team is working to make future applications precise, safe and reproducible.
NIAID/ACE students attend this year’s OSG User School 2022

This past July, the OSG User School 2022 welcomed students from across the globe to learn how to use high-throughput computing in their scientific research.
High schoolers get hands-on with science at Summer Science Camp

After two years of virtual-only events at the Discovery Building, students and teachers from rural Wisconsin high schools returned in-person for the 16th annual Summer Science Camp.
Eliceiri named Open Hardware Trailblazer Fellow

via UW Research

Morgridge investigator Kevin Eliceiri was recently named an Open Hardware Trailblazer Fellow by the Open Source Hardware Association (OSHWA) for his work in imaging innovation.
Summer Science programming returns, both in-person and online

After two years of virtual-only programming, the Morgridge Institute and the UW-Madison campus will once again open their doors to high school students and teachers in-person for the Summer Science Camp, along with continued online workshop sessions throughout the summer.
Morgridge alum awarded for “FANTM” limb virtual technology

Former Morgridge Postdoctoral Fellow Finn Kuusisto was awarded for his work developing information technology to improve virtual reality applications that could one day be applied to biomedical devices.
New Morgridge investigator explores role of diet and metabolism in stem cell function

Daniela Drummond-Barbosa, the Morgridge Institute’s newest investigator, uses the model organism Drosophila to better understand the genetic drivers of stem cell disorders, obesity, infertility and a variety of diseases associated with metabolism.
COVID lawsuits push doctors to provide substandard care

via Wisconsin Examiner

In this Wisconsin Examiner report, Morgridge Bioethicist in Residence Pilar Ossorio addresses the dangerous notion of “whatever the patient wants, the patient gets” when it comes to the rash of unproven and disproven treatments related to COVID.
The role of HTC in advancing population genetics research

Postdoctoral researcher Parul Johri uses OSG services, the HTCondor Software Suite, and the population genetics simulation program SLiM to investigate historical patterns of genetic variation.
Technical tour de force: Orphan proteins in mitochondrial disease

In new findings in Nature, a team at the Morgridge Institute for Research and Washington University School of Medicine in St. Louis analyzed dozens of ‘orphan’ mitochondrial proteins and suggested functions for many of them — an important step to finding better ways to diagnose and treat poorly understood human conditions.
Neutrophils perform metabolic changing act in role as first responder immune cells

Morgridge Investigator Jing Fan and her lab recently published a study in the journal Nature Metabolism that takes a closer look at the unique metabolic activity that powers neutrophils as the first responders in innate immunity.
Congratulations to May 2022 graduates

Congratulations to our 2022 graduating students and research staff moving on into their next chapters. A few of them shared their experiences at Morgridge and their plans for the future.
Big achievement in black hole imaging gets assist from UW scientists

via Wisconsin Public Radio

Miron Livny, Morgridge investigator and UW-Madison computer scientist, describes his Center for High Throughput Computing as a service provider for scientists with big to-do lists. That includes people searching for super-massive black holes.
UW-Madison computer scientist helps create model of supermassive black hole

via WKOW

The Event Horizon Telescope (EHT) was able to create a black hole model thanks to the contribution of Morgridge investigator and UW-Madison computer scientist Miron Livny.
High-throughput computing as an enabler of black hole science

The stunning new image of a supermassive black hole in the center of the Milky Way was created by eight telescopes, 300 international astronomers and more than 5 million computational tasks. The Wisconsin-based Open Science Pool helped make sense of it all.
Game-changer: New tech could transform biotechnology

In new research in Nature Communications, the Joshua Coon Lab describes a game-changing advance that unites the power of mass spectrometry with the potential of electron microscopy (EM) — a finding that could transform biotechnology.
In-person science returns to the Discovery Building

Families returned to Saturday Science at the Discovery Building for the first time since the start of the pandemic.
Bernstein wraps postdoc, joins cancer research startup

After years of building tools for bioinformatics research, Morgridge Postdoctoral Fellow Matt Bernstein takes his skills to industrial cancer research.
Bioethics researcher Yao Zhou awarded Thomas Edison Innovation Fellowship

Morgridge ethics researcher Yao Zhou received the Thomas Edison Innovation Fellowship to study the role of IP rights in advancing biomedical technologies.
Skala highlights value of basic research at UW Day in D.C.

Morgridge Institute Investigator Melissa Skala heralded the importance of the federal investment in scientific research during the annual “UW Day” on April 6 in Washington, D.C.
Jason Cantor Receives Hartwell Individual Biomedical Research Award

via UW Biochemistry

Morgridge investigator Jason Cantor has received a 2021 Hartwell Individual Biomedical Research Award. His was among the ten award-winning proposals that represent early-stage, innovative and cutting-edge technology in medicine and biomedical engineering.
Top prize in Bioethics Cartooning Contest considers substance and style in publishing

Five prizes were awarded in the fifth annual Morgridge Institute for Research Ethics Cartooning Competition, which invites participants to make a cartoon on any ethical issue related to biomedical research.
Study sheds light on how planarians regenerate germ cells

Unlike virtually all animals, the flatworm planaria has the ability to regenerate its germ cells from anywhere in the body. The Morgridge Newmark Lab is finding the molecular footprint of this process for the first time.
New search app gleans ‘collective consciousness’ from a massive research database

For researchers looking to extract useful and relevant data from PubMed — a public database of more than 30 million biomedical research papers — Morgridge scientists have developed a simple and enticing shortcut, called KinderMiner.
Scientists find clues to better understand parasitic Cryptosporidium infection

Morgridge Postdoctoral Fellow Gina Gallego-Lopez leads research to better understand the relationship between the Cryptosporidium parasite and host, and ultimately identifying new therapeutic treatments.
Multiple Morgridge Investigators received prestigious awards in early 2022

Morgridge Investigators Jason Cantor, Kevin Eliceiri, and Melissa Skala received award funding to advance projects in metabolism and biomedical imaging.
James Thomson, renowned UW scientist who brought the world human embryonic stem cells, to retire in July

via Milwaukee Journal Sentinel

James Thomson, the Morgridge Institute and UW-Madison scientist who first isolated and grew human embryonic stem cells, inspiring a generation of researchers, and igniting a furious ethical debate that he would later help resolve, plans to retire after more than three decades of work in Wisconsin.
A science trailblazer retires: Stem cell researcher James Thomson’s legacy changed the future of biology

James Thomson helped the scientific world turn its attention to the remarkable stem cells that give rise to all of the building blocks of life. After more than 30 years with UW–Madison and 15 years with the Morgridge Institute, Thomson has announced plans to retire in July 2022.
Murphy featured in Beloit College Health & Healing Channel

via Beloit College

Dan Murphy, outreach and lab manager at Morgridge, shares advice about working in science education and programming with his alma mater, Beloit College.
Machine Learning and Image Analyses for Livestock Data

The vision of the Digital Livestock Lab is to create state-of-the-art computer vision systems and the largest public database for livestock.
COVID-19: Next steps to normalcy

What is the future outlook of the COVID-19 pandemic? Experts discussed where we are and the path forward on February 17, 2022 in a Fearless Science Speaker Series webinar.
New collaborative research center to provide clearer image of tumor microenvironment

via College of Engineering

Morgridge Investigator Kevin Eliceiri and collaborators at the University of Minnesota will develop and test an integrated toolkit of imaging and data analysis technologies for immunotherapies, funded by the National Cancer Institute.
2021-2022 Morgridge Ethics Cartooning Competition – Public Voting

Sixteen cartoons have been selected as finalists in the 2022 Ethics Cartooning Competition, an annual contest sponsored by the Morgridge Institute.
Time to SHINE: UW, Morgridge spinoff has great hopes for fusion’s future

SHINE, a spinoff company that spent its formative years at Morgridge, is helping usher in the fusion energy age with several technologies, including a safe way to create life-saving medical isotopes.
Skala to develop new imaging approach for retinal diseases

via College of Engineering

Morgridge investigator Melissa Skala has landed a grant from the National Eye Institute to develop a new imaging method that could allow for earlier disease detection, monitoring and treatment evaluation for retinal diseases.
Morgridge, UW alum ‘diving into the deep end’ of vaccine development

After years of sharpening her knowledge of mass spectrometry in the Josh Coon Lab, chemistry PhD alumna Anji Trujillo landed her dream job of working on the front lines of drug development at Pfizer in St. Louis.
Building better proteins with machine learning

Morgridge Investigator Anthony Gitter and his team are tackling big problems (and big datasets) with machine learning. A new study demonstrates how these tools can be used to predict new protein sequences that could improve protein function.
Open wide: Detecting links between what’s in your mouth and illness

Using tiny specks of dental plaque, scientists at the Morgridge Institute for the first time compiled a sophisticated analysis that opens the door to using the trove of micro-organisms in your mouth as an indicator of other health issues.
Optical imaging highlights metabolic interactions that make pancreatic tumor cells grow

An advanced biomedical imaging technique reveals how cancer cells can hijack the metabolic activity of certain non-cancer cells in the pancreas to fuel tumor growth.
Where are they now? Catching up with recent alumni in their new careers

A few of our recent Morgridge alumni reflect on how their research experience at the institute prepared them for their scientific careers.
By citations, UW–Madison faculty demonstrate strong impact

via UW-Madison

Morgridge biomedical imaging investigator Kevin Eliceiri is one of 17 UW-Madison researchers who made the 2021 Highly Cited Researchers List. Eliceiri has been cited more than 68,000 times in 228 publications and is recognized for his cross-disciplinary influence.
Scientists Pinpoint Structure of Antifungal, Challenge Binding Mechanism

via UW Biochemistry

Morgridge affiliate Chad Reinstra, a biochemist at UW-Madison, has unlocked the structure of Amphotericin B (AmB), a powerful and reliable drug that saves lives by obliterating serious fungal infections that can’t be diagnosed quickly.
Thomson Lab alumna gives back in new outreach project

Thomson Lab alumna Shannon Strader returned to her roots at Morgridge to participate in an upcoming outreach feature with PBS Wisconsin Meet the Lab.
Giving middle school students a glimpse into the ‘invisible world’ of viruses

A new digital learning resource developed by PBS Wisconsin called “Meet the Lab,” which gives middle school-aged students a glimpse into high-powered research labs and the scientists who run them, highlights the Morgridge Institute virology research team.
Exploring COVID-19 vaccines for kids

Over 18 months into the COVID-19 pandemic, and vaccines are now available for children 5-11. Experts on the front lines of pediatric vaccine development and public health addressed questions during a Fearless Science Speaker Series webinar on November 9, 2021.
Machine learning guiding early drug discovery process

via WisBusiness

Morgridge Investigator Anthony Gitter presented at the annual BioForward Biohealth Summit about ways machine learning is having a major impact on the early phases of drug discovery.
Researchers, UW educators see bright future for AI in healthcare

via The Cap Times

Anthony Gitter, a Morgridge investigator, discussed his lab’s promising new efforts to use AI to create custom-fit chemicals — or as he described it, “a brand new recipe” for treating illnesses.
Best of the Fest: 2021 Wisconsin Science Festival in photos

We’ve collected some of our favorite moments from “Science on the Square” during the 2021 Wisconsin Science Festival.
Illuminating Alzheimer’s disease through microscopy

Elizabeth Haynes recently joined the institute as a Morgridge Postdoctoral Research Fellow who is harnessing microscopy to model the early progression of Alzheimer’s disease in zebrafish. Haynes’s fellowship is a collaboration between the Kevin Eliceiri Lab and Tyler Ulland in the Department of Pathology and Laboratory Medicine at UW-Madison.
Chemical Legos: A machine learning approach to faster drug discovery

Virtual chemical libraries are capable of producing billions of never-before-synthesized chemical combinations, advancing the quest for beneficial new drugs. Machine learning models are helping find the best candidates.
Explore over 170 virtual and in-person events at the 11th annual Wisconsin Science Festival

From “magic” mushrooms to a celebration of the stars, the 11th annual Wisconsin Science Festival, held October 21-24, will feature over 170 virtual and in-person events.
Finding Clarity: Fellowship supports Sajdak’s career path

Morgridge Postdoctoral Fellow Ben Sajdak bridges advanced microscopy and neuroscience, while bringing his own scientific path into focus.
Resilience: How COVID-19 challenged the scientific world

In late 2019, a novel coronavirus began spreading across the globe. The pandemic still isn’t over, but it hasn’t stopped scientific progress. We spoke with scientists at the Morgridge Institute for Research and the University of Wisconsin-Madison who shared stories of promise, resilience, and lessons learned to come together, overcome challenges and work for the public good.
Coon lab’s ’smart toilets’ project a hot commodity

via The Wall Street Journal

Morgridge investigator Josh Coon’s unique project marrying mass spectrometry technology to the everyday toilet is tabbed as one of the trends to watch in the Wall Street Journal’s “Future of Everything” series.
For the sake of rural science students in Wisconsin, we have to get broadband right

via Milwaukee Journal Sentinel

A editorial by Kim Kaukl, executive director of the Wisconsin Rural Schools Alliance, referenced the Morgridge Institute’s Rural Summer Science Camp as an ideal example of the benefits of online and hybrid learning opportunities in science education.
Imaging method predicts how well stem cells can differentiate into cardiac muscle cells

Morgridge researchers developed an imaging technique that can predict the efficiency of cardiac muscle cell differentiation from stem cells as a method of quality control for potential regenerative therapies.
UGA’s Rozario receives NIH Director’s New Innovator Award

via University of Georgia

Tania Rozario, a 2020 alumna of the Phil Newmark Regenerative Biology Lab at Morgridge, has received a National Institutes of Health Director’s New Innovator Award for high-risk, high-reward research she is pursuing as a University of Georgia professor.
Navigating the unCHARTed: web tool explores public sequencing data for cancer research

Morgridge Postdoctoral Fellow Matthew Bernstein developed a web tool to explore public RNAseq datasets to facilitate analysis for cancer researchers.
Hunting viral variants across Wisconsin, powered by high-throughput computing

When dangerous COVID viral variants were sweeping the globe, David O’Connor was busy tracking their spread in Wisconsin. His secret weapon? High-throughput computing.
The Wisconsin Idea at a million feet up

Students across the state connect with astronauts aboard the International Space Station.
Morgridge postdoc awarded first AAAS Science & Technology Policy Fellowship in the U.S. Department of the Treasury

Morgridge Postdoctoral Fellow Amritava Das earned prestigious AAAS Science & Technology Policy Fellowship and landed first-ever placement at the U.S. Department of the Treasury.
Wisconsin bioethics project chronicles pregnancy, substance use disorder and the law

A 50-state analysis of laws related to substance use and pregnancy will be a critical first step in helping medical leaders assess the impact of the widespread opioid epidemic.
Raja awarded the “Women Scientist Award” for achievements in bioinformatics

Postdoctoral researcher Kalpana Raja received the “Women Scientist Award” from the Society for Bioinformatics and Biological Sciences for her scientific merits.
CZI project to enable high-resolution mapping of molecules within cells

Tim Grant is part of a new project supported by the Chan Zuckerberg Initiative (CZI) that hopes to create a three-dimensional map that aligns molecules in their proper neighborhoods within a cell.
Serving up summer science

The Summer Science Workshop Series kicks off June 23 with 106 students and 29 educators from 21 schools in the Wisconsin Rural Schools Alliance and seven sites in the Upward Bound program that focuses on underrepresented and first-generation pre-college students.
Honoring Ernie Micek: ‘always doing the right thing’

Ernest ‘Ernie’ Micek was a global trade leader and entrepreneur who brought decades of experience to help the Morgridge Institute by ‘always doing the right thing.’
COVID-19 Update: Vaccines, viral variants and the path to successful re-opening

The impacts of COVID-19 are improving worldwide. But virology experts argue we must stay vigilant to protect public health for a safer, more productive future.
Stopping the next pandemic: We need a ‘space race’ against viruses

The COVID-19 pandemic is not an isolated event, but one step in an accelerating progression of viral threats. Preventing the next pandemic will take a massive scientific commitment.
Making microscopy portable and affordable

Portable Flamingo microscopes have the potential to democratize science by opening up new opportunities to wide ranges of researchers and institutions.
Congratulations to May 2021 Graduates

Congratulations to our 2021 graduating students and research staff moving on into their next chapters. A few of them shared their experiences at Morgridge and their plans for the future.
Top prizes in ethics cartooning contest address COVID-19 and more

Five prizes were awarded in the fourth annual Ethics Cartooning Competition, addressing the social impacts of scientific research, like issues on public health and communication during the COVID-19 pandemic.
The (cell) medium is the message: A new tool for studying cell biology in a dish

Morgridge investigator Jason Cantor is partnering with Thermo Fisher Scientific to give biologists a new medium to study human cells in their most natural state.
Imaging technique sheds light on a notoriously slow-growing cancer

Neuroendocrine cancers grow so slowly they often evade detection before it’s too late. By mimicking that slow growth in the lab, the Melissa Skala Lab hopes to speed up the creation of more effective treatments.
Biden offers American science a fresh chance to prove its value to society

President Biden has laid out a vision for elevating the importance of science in this country. But it’s up to all scientists to help educate Americans about the benefits of science and the discoveries that have changed our world.
Biden offers American science a fresh chance to prove its value to society

via The Hill

President Biden has laid out a vision for elevating the importance of science in this country. But it’s up to all scientists to help educate Americans about the benefits of science and the discoveries that have changed our world.
COVID 19: How to talk about vaccines (and find common ground)

Multiple COVID-19 vaccines are available, but some people are on the fence about getting their shot. Approaching a conversation with vaccine-hesitant friends and family may be challenging. Three scientists and public health experts spoke to more than 250 members during a Fearless Science Seminar Series.
2021 Morgridge Ethics Cartooning Competition – Public Voting

The Morgridge Ethics Cartooning Competition invited entrants to make a cartoon on any ethical issue arising in or from biomedical research.
Redox imaging allows measurement of drug responses in lab-grown cancer samples

Scientists have developed a nondestructive way of measuring drug treatment responses in lab-grown cancer samples.
Schools taking more virtual field trips during COVID-19 pandemic

via NBC 15

Districts are finding creative ways to safely give students unique experiences while staying in the classroom.
Ashley Cortes Hernandez hopes to spread STEM enthusiasm among Latinx youth

Ashley Cortes Hernandez is excited to bring Latinx representation to the team in hopes of making STEM more accessible to underrepresented communities in her new role as assistant outreach coordinator for Discovery Outreach.
Morgridge scientists collaborate with Genentech to soup up Cryo-EM imaging

A partnership with Genentech is helping Morgridge Investigator Tim Grant improve software that helps scientists harness the incredible power of cryo-EM microscopes for drug discovery.
Researchers publish findings on use of a more human-like cell culture medium to explore gene essentiality

The Jason Cantor Lab at Morgridge is utilizing a new cell culture medium to ask how critical genes are to the survival and reproduction of human cells under different growth conditions. The technique could have important ramifications for the treatment of human diseases.
Third booster dose of COVID-19 vaccine to fight new variants in the works

via CBS58

Citing presentations from the Feb. 24 Morgridge Institute Fearless Science Seminar, CBS 58 in Milwaukee reported that new booster vaccines are in development that will specifically target COVID 19 variants that have recently emerged around the world.
COVID-19: The science of vaccines

Johan den Boon, anesthesiologist Dr. Bill Hartman, and pediatric infectious disease specialist Dr. James Conway presented for a webinar about the science of vaccines.
Online Field Trips bring science to the state

For more than ten years, the Field Trip Program has brought students and teachers to Madison for a day of activity and exploration. But when the COVID-19 pandemic shuttered on-campus activity, the Discovery Outreach Team had to get creative.
Beckman Foundation awards Morgridge Investigators to develop smart light sheet technology

Jan Huisken and Kevin Eliceiri will lead an initiative to develop and advance light sheet microscopy technology through a grant funded by the Beckman Foundation.
Beyond Fun: Discovery Outreach strengthening bond between science, society

The Discovery Outreach team is growing an iceberg. The visible part above the water is made up of the tens of thousands of people of all ages who participate in programs each year. And the mass below the surface contains hundreds of Wisconsin scientists, researchers and experts who are adding their voice to science engagement.
Thomson Lab looks to make major health impact with artery engineering project

Stem cell pioneer James Thomson is leading a potentially transformational project to develop a safe and functional cell-based artificial artery that could be pulled from medical inventories and used by vascular surgeons.
Building a better bioimaging community: Chan Zuckerberg Initiative supports international partnership

via The Daily Cardinal

The Morgridge Institute’s Kevin Eliceri describes how a new grant will help foster learning and community for UW-Madison students interested in bioimaging.
Bringing fluorescence imaging out of the dark

Morgridge Institute spinoff company OnLume had a banner year in 2020, receiving Food and Drug Administration (FDA) approval, meeting its venture funding goals and launching its first clinical trial with a California company. And they are getting expert feedback from UW Health physicians on their groundbreaking fluorescence imaging device.
Building a better bioimaging community: Chan Zuckerberg Initiative supports international partnership

Investigator Kevin Eliceiri leads a grant with BioImaging North America, which was recently awarded $1.2 million in funding from the Chan Zuckerberg Initiative.
Where are they now? Morgridge alumni look back (and ahead) at their careers

A few of our Morgridge alumni shared thoughts on their research experience at the Morgridge Institute, their plans moving forward and their warm shoutouts to some of the people who helped them along the way.
Amani Gillette: Passing on a fascination with the unknown

Medical Engineering graduate student Amani Gillette has become one of the Morgridge Institute’s top ambassadors for science outreach.
Fab Lab alumna tackles machine learning at Stanford

Kayla Huemer, a graduate of the Morgridge Fab Lab and alumna of UW-Madison, is tackling machine learning at Stanford. Huemer brings a depth of experience in engineering and design which she honed during her time in the BerbeeWalsh Prototype Pathway.
Cell atlas of schistosome may hold key for new treatments

via Sanger Institute

Morgridge postdoctoral fellow Jayhun Lee is a lead author in a new study that outlines the first-ever cell atlas of the tropical parasite schistosome, an advance that could provide new alternatives for fighting a disease that impacts more than 200 million people globally.
Minority students share their stories in science so others feel power of representation

via Wisconsin State Journal

Wisconsin students and teachers took part in an online session called “My Story in Science So Far: From Voices Underrepresented in Science,” as part of a field trip to the Wisconsin Science Festival in October.
Breaking down barriers to pancreatic cancer care in Wisconsin

Researchers at the Morgridge Institute and UW-Madison want to ensure that pancreatic cancer treatment options are accessible to all — regardless of race, ethnicity, or insurance status — so that patients can make the most informed decisions regarding their care.
Machine learning our way through a billion-chemical library

Inspired by the need for smarter and cheaper ways to screen chemicals for potential therapeutic targets, Morgridge investigator Anthony Gitter is finding answers with machine learning tools.
Measuring blood flow with a beating “heart-on-a-chip”

With every heartbeat comes a rhythmic pulse that helps blood flow through the body. Understanding this pulsatile flow can offer insights on the impacts of blood vessel development and cardiovascular disease. New research uses an “organ-on-a-chip” model to study pulsatile flow in a more biologically relevant way.
Engineering through and after COVID-19: A Global Perspective

Engineers are well-equipped to address the world’s development challenges, but good engineering alone is not enough. We need the emerging field of ‘global engineering,’ argues Kevin Eliceiri, a Morgridge medical engineering investigator, and Rebecca Alcock, a recent alumna of the UW-Madison graduate program in biomedical engineering.
The Contested Ethics of a COVID-19 Vaccine

Morgridge bioethicist in residence Pilar Ossorio, Jonathan Kimmelman, and Seema Shah joined Gabriella Gerhardt on October 27 to discuss the complex ethical questions surrounding a coronavirus vaccine.
Jose Ayuso wins “Best Paper Award” at the 2020 Micro Total Analysis Systems conference

Morgridge Postdoctoral Fellow Jose Ayuso won the “Best Paper Award” at the 2020 Micro Total Analysis Systems conference for his work on cancer microenvironments in tumor evolution and progression.
National Science Foundation establishes a partnership to advance throughput computing

Morgridge and UW-Madison are partners on a $22.5 million project from the National Science Foundation to advance high-throughput computing technology and promote usage nationwide.
New technology tracks role of macrophages in cancer spread

A Morgridge imaging study of macrophages — immune cells that are important to human health, but paradoxically can help some cancers grow and spread — is offering better ways to understand these cells and target them with immunotherapies.
‘Molecular Signature’ In Blood May Indicate Coronavirus Disease Severity

via Forbes

Researchers at the Morgridge Institute for Research, Albany Medical Center, and UW-Madison assembled a profile of biological molecules that correlated not only with COVID-19 infection, but with disease severity. More target molecules will likely be found as others analyze the data, which is freely available online.
The 10th annual Wisconsin Science Festival goes virtual in extraordinary ways

The 10th annual Wisconsin Science Festival was held virtually for the first time this past weekend, highlighted by a virtual road trip. Children of all ages could view tours, panels, lessons and so much more virtually, allowing them to travel all over the state without ever leaving their homes.
Wisconsin Innovation Awards Announce 2020 Winners at Virtual Ceremony

via Wisconsin Innovation Awards

OnLume Surgical, a spinoff company originating from Morgridge Institute research, has received a 2020 Wisconsin Innovation Award. The company, which develops precise fluorescence for image-guided surgery, was chosen for the award from more than 400 nominees.
Unraveling the network of molecules that influence COVID-19 severity

Researchers have identified more than 200 molecular features that strongly correlate with COVID-19 severity.
NSF leader Fleming Crim to speak at the Wisconsin Science Festival

National Science Foundation leader Fleming Crim will give a talk on Friday, October 16 at 2 p.m. titled NSF Broader Impacts: Fostering Connections to Expand the Societal Benefits of Basic Research, as a part of the Wisconsin Science Festival’s speaker series.
OnLume Surgical is a Finalist for the 2020 Wisconsin Innovation Awards

via Business Wire

Morgridge Institute spinoff company OnLume Surgical, a medical device company developing novel imaging systems for use during surgery, was recognized as one of the ten (10) finalists for the 2020 Wisconsin Innovation Awards.
Optical Society elects Eliceiri as fellow

via UW College of Engineering

Morgridge Institute investigator and UW-Madison biomedical engineering professor Kevin Eliceiri has been elected a fellow by The Optical Society, an honor given to only one in 10 members.
Explore over 100 virtual events at the 10th annual Wisconsin Science Festival

From the novel coronavirus to food sciences, the 10th annual Wisconsin Science Festival, held October 15-18, will feature over 100 virtual events.
UW-Madison gets $23 million grant for frozen imaging at atomic scale

via Wisconsin State Journal

UW-Madison and the Morgridge Institute for Research will get $22.7 million over six years from the National Institutes of Health to create a national center for imaging techniques that flash-freeze biological molecules to let scientists see a better picture of their function.
Keys to a successful COVID-19 vaccine

As health officials move closer to developing safe vaccines against COVID-19, Morgridge virology expert Paul Ahlquist argues for the need for patience and trust during what will be the largest vaccination effort in more than 70 years.
New national imaging center has potential to transform medicine

A national research initiative announced today will place the University of Wisconsin-Madison at the forefront of a revolution in imaging fostered by cryo-electron microscopy and cryo-electron tomography.
Endless Frontier Act to revitalize, transform Midwest industries

via WisPolitics

“A mill won’t last long if there is no mine, but a mill is required to get the products to the market,” Morgridge investigator Melissa Skala said during a Wisconsin Technology Council webinar. “What I find so powerful about the Endless Frontier Act is that it supports both the mine and the mill to benefit innovation across the spectrum.”
InsideWis: Even in fractious times, the need for a vital, secure economy can unite lawmakers

via Wisconsin Technology Council

Morgridge investigator Melissa Skala participated in a Wisconsin Technology Council webinar promoting bipartisan support for the Endless Frontier Act, which would bolster national research funding.
Jan Huisken awarded 2020 Lennart Nilsson Award for developments in light-sheet microscopy

Jan Huisken, medical engineering investigator at the Morgridge Institute for Research, has been awarded the 2020 Lennart Nilsson Award for outstanding achievements in biological imaging.
Challenging and fun: Prototype Pathway propels forward-thinking medical engineer

After ten years as a student, mentor, and engineer in the Morgridge Institute, Ben Cox is finishing his postdoctoral fellowship in the BerbeeWalsh Prototype Pathway and heading to the University of Chicago Polsky Center for Entrepreneurship and Innovation.
Summer Science Workshop helps students form their science identity

The workshop series, which wrapped up in late July, brought more than 100 students and 15 teachers “face-to-face” to learn online from scientists at the Morgridge Institute for Research.
Multi-omic data and interactive web tool made publicly available to aid COVID-19 research

Why is it that some COVID-19 patients become extremely ill and die, while others experience only mild symptoms? A new study uses mass spectrometry, RNA sequencing, and machine learning to explore the molecular traits that might influence the severity of the disease.
‘Like a Map of the City’ – How Metabolic Networks Contribute to Our Understanding of Cancer’s Growth

via UW Health

When Morgridge investigator Jing Fan thinks about metabolism, she is focused on the complicated network of biochemical reactions. Her lab has been working on understanding metabolism in a quantitative, systematic way.
MMI Fellow seeks to understand sugar production in yeasts

Kaitlin Fisher, the 2020 Morgridge Metabolism Interdisciplinary Fellow, aims to understand the genes that influence carbon metabolism and the process of gluconeogenesis in yeasts.
How schistosome worms defy host immune systems

via SciDev.Net

Morgridge researchers uncovered in a new study how schistosomes, parasitic flatworms that infect more than 200 million people in the tropics, trick the host’s immune system and continue producing eggs for decades.
Label-Free Autofluorescence Imaging Method Differentiates Between Active, and Off-Duty T Cells

via Genetic Engineering & Biotechnology News

Researchers at the Morgridge Institute and UW-Madison have developed a novel label-free imaging technique that exploits autofluorescence in cells to differentiate between active and off-duty T cells.
Miron Livny awarded 2020 IEEE Award for Outstanding Technical Achievement and 2020 High Impact Paper Award

via UW Comp Sci

Computer Sciences Professor Miron Livny has been selected for two prestigious IEEE awards: the 2020 IEEE Technical Committee on Distributed Processing (TCDP) Award for Outstanding Technical Achievement and a 2020 IEEE TDCP ICDCS High Impact Paper Award.
The big gulp: Inside-out protection of parasitic worms against host defenses

A team of developmental biologists at the Morgridge Institute for Research has discovered a means by which schistosomes, parasitic worms that infect more than 200 million people in tropical climates, are able to outfox the host’s immune system.
Seize the Moment: Adapting old tools for a novel coronavirus

Morgridge scientists John Brubacher, Anthony Gitter, Brian Bockelman, Ben Cox and Katie Overmyer, joined Gabriella Gerhardt on July 22 for a Fearless Science webinar about rapidly applying technology and methods to answer COVID-19 questions.
Novel label-free imaging technique brings out the inner light within T cells

A new imaging method developed by the Skala lab uses the natural autofluorescence within cells to assess T cell activity. The technique could help assess T cell involvement in immunotherapies.
From the CEO: Trial, error and pandemics

The scientific community’s shift on wearing masks to fight the pandemic tells us something important about the scientific process. Science can get things wrong, but the constant push for new knowledge — combined with an ability to admit and correct mistakes — should always prevail.
Local research findings to aid in development of treatment for COVID-19

via WMTV

UW-Madison announced Tuesday that scientists from the university and the Morgridge Institute for Research have been able to capture “strikingly improved images” of virus group, which could help aid in the creation of antiviral drugs and treatment for COVID-19.
Advanced Cryo-EM reveals viral RNA replication complex structure in stunning detail

For the first time, scientists at the Morgridge Institute for Research have generated near atomic resolution images of a major viral protein complex responsible for replicating the RNA genome of a member of the positive-strand RNA viruses.
An invisible hand: Patients aren’t being told about the AI systems advising their care

via STAT

Morgridge bioethicist in residence Pilar Ossorio commented in STAT about the growing problem of hospitals not disclosing to patients how many clinical decisions are now being made with artificial intelligence.
Miron Livny receives 2020 IEEE Outstanding Technical Achievement Award

Miron Livny is the recipient of the 2020 IEEE Outstanding Technical Achievement Award due to his influential contribution of the HTCondor system for distributed and high-throughput computing.
Coronavirus is revolutionizing scientific practices and communication. Here’s how

via Argus Leader

Morgridge bioethicist in residence Pilar Ossorio warns that “conditions are ripe for cutting corners” in the research push to combat COVID-19.
In our post-COVID world, science must be our new frontier

via The Hill

Writing in The Hill, Morgridge CEO Dr. Brad Schwartz provides insight and context for scientific discovery as a foundation for economic prosperity. As the United States looks to science to help us get past the COVID-19 pandemic, we would be well advised to also look back.
Smart toilets could transform health tracking. Here’s how

via ZDNet

Morgridge investigator Josh Coon describes how “smart toilets” could be the new frontier in personalized medicine.
Statement from CEO Brad Schwartz on the appointment of Tommy Thompson as UW System interim president

Morgridge CEO Brad Schwartz offers a statement of support for the appointment of Tommy Thompson as interim president of the University of Wisconsin System.
Science camp for rural high schoolers goes virtual

via NBC 15

For over ten years, rural high school students have come to Madison to take part in the Rural Summer Science Camp at the Morgridge Institute. This year, the camp will still take place virtually.
Rural Summer Science Camp goes digital

The novel coronavirus presented a significant hurdle for Discovery Outreach team—how do you bring science to rural students during a pandemic? Now in its 14th year, the Rural Summer Science Camp is celebrating a new milestone: an entirely digital experience.
Could pre-existing conditions hold the clue to new COVID-19 drugs?

The deadliest cases of COVID-19 often arise in patients with a variety of pre-existing conditions, known to medicine as “comorbidity.” A Morgridge Institute for Research project will investigate those disease relationships in the search for new drug treatments.
Morgridge Institute board names new chair, welcomes three new trustees

via Wisconsin Technology Council

The Morgridge Institute for Research Board of Trustees voted on Wednesday to elect Carl Gulbrandsen, emeritus managing director of the Wisconsin Alumni Research Association (WARF), as the new chairman of the 20-member Morgridge Institute board.
Morgridge Institute Board names new chair, welcomes three new trustees

The Morgridge Institute for Research Board of Trustees voted on Wednesday to elect Carl Gulbrandsen, emeritus managing director of the Wisconsin Alumni Research Association (WARF), as the new chairman of the 20-member Morgridge Institute board.
Overcoming COVID-19 and future pandemics: new tools to control viral threats

In light of the COVID-19 pandemic, Paul Ahlquist and Tony Gitter joined CEO Brad Schwartz in a webinar where they discussed COVID-19 and the broader context of viral pandemics and how we respond to them.
Detecting cellular diversity to sharpen personalized cancer treatments

via UW College of Engineering

Melissa Skala, a University of Wisconsin-Madison associate professor of biomedical engineering, and collaborators have used an approach called optical metabolic imaging (OMI) to effectively assess that heterogeneity and related treatment responses in organoids created with tissues from patients with breast cancer and pancreatic cancer.
UW-Madison researchers plan return to lab

via NBC15

Morgridge CEO Brad Schwartz is featured in a report discussing the return of in-person research following nearly three months of social distancing due to the COVID-19 pandemic.
Using nanobodies to fish for coronavirus clues

A Morgridge Institute for Research project intended to shed light on planarians — remarkable flatworms capable of almost limitless regeneration — is being repurposed to focus on the novel coronavirus causing COVID-19.
Saturday Science transitions to a digital outreach experience

The Discovery Outreach team demonstrates their commitment to provide valuable programming by translating Saturday Science into a digital experience during an unprecedented time.
The Power List 2020

via The Medicine Maker

Stem cell pioneer and Morgridge investigator James Thomson was named to the Power List 2020 for his contributions to advancing the field of medicine to save lives and improve the world.
Albany Med partnering with University of Wisconsin for COVID-19 research

via Albany Times Union

An Albany Medical Center Hospital physician is partnering with the University of Wisconsin-Madison to study different patient experiences with COVID-19.
Albany Med doctor partners with university on coronavirus research

via WTEN-TV

An Albany Medical Center pulmonologist is teaming up with the University of Wisconsin-Madison to study why COVID-19 patients experience the virus more severely than others.
Albany Med Pulmonologist Partners with University of Wisconsin on COVID-19 Research

via Albany Medical College

An Albany Med physician who has been caring for COVID-19 patients during the pandemic is partnering with the Morgridge Institute and UW-Madison to study why some patients experience COVID-19 more severely than others.
Chronicling pandemic science in real time

Morgridge virology investigator Anthony Gitter, an assistant professor of biostatistics and medical informatics at UW-Madison, has co-developed a software tool called Manubot to help orchestrate a rapid expert assessment of COVID-19 diagnostics and therapeutics.
Faculty receive WARF, Kellett, Romnes awards

via UW-Madison

Morgridge Affiliate Dominique Brossard and Morgridge Investigator Joshua Coon are 2020 recipients of Kellett Mid-Career Awards, given by the Wisconsin Alumni Research Foundation every year to recognize mid-career excellence.
Congratulations to May 2020 Graduates

Congratulations to the graduating students and research staff as they move onward and upward. A few of these students and staff shared about their time at the Morgridge Institute, their accomplishments and their plans for what’s next.
Albany, Wisconsin teams search for molecular clues to defeat COVID-19

In the center of the COVID-19 pandemic, many hospitals are racing to maintain quality care for patients with severe disease while facing a shortage of resources and limited understanding of the novel coronavirus.
COVID-19: A wake-up call for the need for new antiviral weapons

Given the death toll and multi-trillion dollar costs of COVID-19, it’s not hyperbole to suggest that an effort on the scale of the Space Race is needed to break the cycle of viral pandemics.
In COVID-19 response, don’t let urgency trump sound science

Bioethicist Pilar Ossorio says the world could be at risk of sacrificing essential knowledge for fighting COVID-19 and future deadly viruses if the COVID-19 response is not accompanied by sound research.
Making a difference: Madison makers build safety equipment for frontlines of COVID-19 fight

via The Capital Times

From designers and engineers to sewists and 3D printing hobbyists, they’re joining a global movement to combat the shortage of personal protective equipment.
Third Annual Bioethics Cartooning Contest Winners

Charlotte Kanzler, a first-year graduate student in the UW-Madison Cellular and Molecular Biology program and a member of the Phil Newmark lab at Morgridge, took the top prize in the third annual Ethics Cartooning Contest.
Tim Grant: Making sense of cellular machinery

Tim Grant, a cryo-electron microscopy pioneer, joins the Morgridge Institute this month as the newest investigator. Grant joins a growing collaboration at UW-Madison where he will use cryo-EM to help biologists see the structure of molecules within cells.
Morgridge part of national effort to improve healing of complex wounds

The Morgridge Institute for Research is part of a multi-institution research project to develop a device that improves muscle tissue healing for serious injuries, using a combination of artificial intelligence, bioelectronics, and regenerative medicine.
We’re in this together

Morgridge CEO Brad Schwartz provides an update on how we’re keeping scientists and teams safe during the COVID-19 pandemic.
Discovery Building closes to public; stay informed on COVID-19 pandemic

As of March 18, the Discovery Building, home of the Morgridge Institute for Research, will be closed to the public. All public events in the building are canceled. Visit here for important COVID-19 updates.
High-throughput computing in action: Demystifying our unconscious brain

High-throughput computing facilitated at the Morgridge Institute is helping scientists explore one of the mysteries of human consciousness: How the brain processes information while we are under anesthesia or asleep.
Skala Lab: New tools for cancer immunotherapy

via WARF

Emerging cell therapies are giving hope to cancer patients, but new analytical tools are desperately needed. Melissa Skala and her team are going all in on the challenge.
Madison company’s surgery imaging device approved by FDA

via Wisconsin State Journal

A device to help surgeons better see tissue during operations has been approved by the Food and Drug Administration. The technology is based on research at the Morgridge Institute for Research.
2019-2020 Ethics Cartooning Contest – Public Voting

The Morgridge Ethics Cartooning Competition invited entrants to make a cartoon on any ethical issue arising in or from biomedical research. Now, you can help choose the competition winners.
Lessons learned from a year in Washington

via Chemical & Engineering News

Danielle Lohman, a former member of the Pagliarini Lab and a UW-Madison alumna, talks about her first year working in the Department of State. Lohman is one of six Ph.D scientists to receive a AAAS Science and Technology Policy Fellowship.
To stop pancreatic cancer from spreading, cut out the chatter

via Massive Science

Morgridge investigator Melissa Skala shares her perspective on a promising new approach to treating pancreatic cancer in this feature from Massive Science.
‘Smart’ toilet analyzes your pee, may revolutionize personal health

via USA Today

Scientists at the University of Wisconsin think their “smart toilet” is capable of monitoring your health and discovering early signs of diseases.
China Is Using DNA from Uighurs to Predict Physical Features

via The Scientist

Morgridge bioethicist in residence Pilar Ossorio comments on the ethical perils of China’s efforts to use DNA-based technology to recognize faces — a potential weapon for racial profiling.
Pagliarini lab members attend mitochondrial disease walk, interact with patients

via UW-Madison Biochemistry

Events hosted by UMDF have enabled the Pagliarini Lab to connect with those who may directly benefit from the findings of their research: patients with mitochondrial disease.
Professor will make ‘workhorse’ microscope more powerful

via UW-Madison

Kevin Eliceiri says he has always believed that science is best done by building on the work of others and openly sharing what you have done.
The weird science behind smart toilets and your pee

via Mashable

A new, small-scale study published in Nature this month seeks to determine whether regular urine collection and analysis of the thousands of telling, changing indicators in our pee can reliably serve up information about a person’s health.
Can ‘smart toilets’ be the next health data wellspring?

Wearable, smart technologies are transforming the ability to monitor and improve health, but a decidedly low-tech commodity — the humble toilet — may have potential to outperform them all.
Protecting against a devastating tropical disease

Schistosomiasis is one of the most devastating tropical diseases in the world. The Newmark Lab wants to develop something that prevents this parasitic infection.
Peering into a more ‘human’ petri dish

The recent development of physiologic media holds immense potential to improve understanding of human biology.
Tiny aquatic animals may combat schistosomiasis

via ScienceNews

Tiny aquatic invertebrates, once a nuisance to scientists studying snail fever, may actually hold the key to fighting the spread of the tropical disease.
Best of the Fest: 2019 Wisconsin Science Festival in photos

The Wisconsin Science Festival—now in its ninth year—offered more than 330 events across the state for people of all ages to dive into science topics.
Tiny Creature Could Help Prevent Devastating Parasitic Disease

via Howard Hughes Medical Institute

HHMI reports on the Newmark Lab’s discovery and purification of a substance made by rotifers that can paralyze the worms that cause schistosomiasis, a dangerous infection that affects 200 million people worldwide.
Parasite paralysis: A new way to fight schistosomiasis?

The Phillip Newmark Lab has isolated a natural chemical capable of paralyzing the parasitic worm schistosome, opening the door to new ways to combat a neglected tropical disease that sickens more than 240 million people.
U.S. Sen. Baldwin and the scientists carrying on her grandfather’s work

via Madison Magazine

At the Morgridge Institute for Research in the Discovery Building on the UW–Madison campus, David Green’s granddaughter — U/S. Sen. Tammy Baldwin — met the scientists who are continuing his early study of metabolism science, in hopes of breakthroughs that will help treat or reverse numerous diseases.
Protecting the most vulnerable patients during anesthesia

Pediatric anesthesia is a stressful and critical procedure. A project with the Morgridge Fab Lab aims to create a new medical device that alerts clinicians to compromised airways.
Sen. Tammy Baldwin takes in ‘locally sourced science’ at Morgridge Institute

Forward-thinking science and childhood memories came full circle on Wednesday for U.S. Sen. Tammy Baldwin, who visited a lab at the Morgridge Institute for Research that is carrying on the inspired legacy of her grandfather, David E. Green.
A Note to the Nobel Prize Selection Committee

via Scientific American

As 2019 Nobel Prize announcements unfold, Morgridge CEO Brad Schwartz reflected on his all-time favorite winner. “Howard Temin represented what society expects from us and had the characteristics that make society willing to fund our work,” Schwartz wrote in Scientific American. “People want scientists who get up every morning committed to finding the truth.”
Science Festival Panels Examine Science and Society

via Wisconsin Institute for Discovery

Panels on Oct. 17 and 18 during the Wisconsin Science Festival will examine representation and inclusion in science and science in entertainment and the arts. Both afternoon panels will take place in the Discovery Building.
Illuminating Better Cancer Treatments with Light

via Wisconsin Public Television

Peter Favreau, a postdoctoral researcher at the Morgridge Institute for Research, discusses how the use of Optical Microscopy is helping to create individualized effective cancer treatments based on each patient’s tumor cells.
Tapeworms need to keep their head to regenerate

Scientists have identified the stem cells that allow tapeworms to regenerate and found that their location in proximity to the head is essential, according to a new study in eLife.
Wisconsin Science Festival encourages science exploration for all with 200+ events statewide

The 2019 Wisconsin Science Festival, held Oct. 17-20, will feature more than 220 events statewide and include everything from fossil exploration and robotic engineering to animal encounters and the science of Star Wars.
Scientists explore the role of metabolism in immune response

In a new study published in Nature Metabolism, the Jing Fan Lab highlights how changing metabolism can regulate the course of an immune response.
Broad-spectrum approaches could tip the balance against virus threats

In the game against an essentially unlimited pool of virus threats, humanity is seriously outmatched. The Ahlquist Lab is working to develop broad-spectrum antivirals, solutions that will target many viruses at once.
Test Pilot Geese, Planetary Wrecking Balls and Super AI Vision: The Week’s Best Science GIFs

via Scientific American

The Morgridge Institute’s project to capture early developmental timing of humans “in a dish” was included in The Scientific American’s “Best Science GIFs” feature. This weekly feature highlights the most amazing short video clips produced in the world of science.
Human developmental clock mimicked in a dish

A Morgridge regenerative biology team has created a first-ever human model for developmental timing: A “clock in a dish” that will help explore mysteries of early human development.
Pagliarini wins ASBMB Young Scholar Award 2020

Dave Pagliarini won the Earl and Thressa Stadtman Young Scholar Award given by the American Society for Biochemistry and Molecular Biology (ASBMB).
Major microscopy project coming to life with new talent, technology additions

Tim Grant, a research specialist at the Howard Hughes Medical Institute’s (HHMI) Janelia Farm Research Campus, is the latest addition to the core team.
MMI Fellow develops new model for parasite study

Bruno Martorelli Di Genova wants to eliminate the use of cats in the study of the parasite Toxoplasma gondii, and the results of his groundbreaking research suggest he could do just that.
Developing tools to better understand, predict preterm birth

Preterm birth is a global health problem without a solution. New research aims to develop non-invasive, safe imaging tools to better identify the risk of preterm birth.
Morgridge Rural Summer Science Camp extended for additional week

via The Badger Herald

The Morgridge Summer Science Camp seeks to immerse rural high school students into research and allow them to experience a larger, urban research campus.
Morgridge-Milwaukee collaboration gets statewide recognition

via Wisconsin State Journal

Tom Still, president of the Wisconsin Technology Council, focused his statewide business column on July 21 on a novel eye research partnership between the Morgridge Institute and Medical College of Wisconsin.
Pagliarini wins young scholar honor

via American Society for Biochemistry and Molecular Biology

Morgridge Institute metabolism investigator Dave Pagliarini will receive the 2020 Earl and Thressa Stadtman Young Scholar Award from the American Society for Biochemistry and Molecular Biology (ASBMB). The award honors outstanding scholars with ten years or fewer of postdoctoral experience.
High school students add science to their summer

For the last three weeks of July, the Discovery Building hosted
70-plus high school students and teachers for the Rural Summer Science Camp.
BioForward supports Rural Summer Science Camps

The Rural Summer Science Camp received a boost this year
from BioForward, an association representing more than 200 biohealth companies in Wisconsin.
2019 Frontiers in Metabolism meeting explores advances in metabolic research

This fall, the Morgridge Institute for Research will convene international leaders in metabolic research at the third Frontiers in Metabolism—Mechanisms of Metabolic Diseases meeting.
Rural Summer Science Camp expands opportunities, curriculum in its 13th year

The Morgridge Rural Summer Science Camp, where rural high school students and teachers take a deep dive into science research over the course of a week, is expanding and offering a third week of camp thanks to new support from a National Science Foundation (NSF) project.
Jacquelyn Fredrick joins Morgridge Board of Trustees

Jacquelyn Fredrick, a longtime executive with one of the nation’s leading providers of blood health solutions, has joined the Morgridge Institute for Research Board of Trustees.
When Small Worlds Collide: Collaboration Behind the Microscope with Liz Haynes and Henry He

via Masters of Microscopy

Welcome to Masters of Microscopy: The People Behind the Lens, where we showcase and celebrate the individuals who are the heart of the Nikon Small World competitions. They are scientists, artists, researchers, educators and everyday curious individuals who uncover the fascinating microscopic world around us.
Novel imaging tech brings together Madison, Milwaukee vision researchers

A Madison-Milwaukee scientific partnership is powering an effort to better understand the complicated mechanics of human vision.
An order of microscopy, to go

Our portable, shareable microscope, called Flamingo, offers a chance for biologists who have a crazy idea to reach out to us do some great research — and for us to build a custom instrument to solve unique questions in biology.
Growing transplantable arteries from stem cells

via FierceBiotech

Blood banks have been vital in medical care since the early 1900s, and now a team of scientists at the Morgridge Institute for Research in Madison, Wisconsin, wants to take the concept a step further.
Congrats to our 2019 graduating students

Congratulations to the graduating students and research staff who will be moving onward and upward. A few of these students and staff shared about their time at the Morgridge Institute, their accomplishments and their plans for what’s next.
Stem cell scientists clear another hurdle in creating transplant arteries

Scientists at the Morgridge Institute are working toward a dream of creating artery banks with readily-available material to replace diseased arteries during surgery. Recent work highlights highlights a better way to grow smooth muscle cells, putting the science one step closer to that goal.
Faculty receive WARF, Kellett, Romnes awards

via UW-Madison

Dave Pagliarini, associate professor of biochemistry and director of the Morgridge Institute for Research’s Metabolism Theme, studies mitochondria — ubiquitous organelles essential for cellular metabolism. His lab integrates classic biochemistry with large-scale methodologies to systematically define the functions of uncharacterized mitochondrial proteins and to establish the detailed mechanisms that drive disease-related mitochondrial pathways.
‘Protein Pinball’ machine illuminates intricacies of bioinformatics research

Anthony Gitter faced a challenge: How could he translate his work into something children could understand and maybe even enjoy? The answer to that question: ‘protein pinball.’
Overmyer named new associate director of mass spec lab

Katherine Overmyer, a former Morgridge postdoctoral fellow, was named the associate director of the Laboratory for Biomolecular Mass Spectrometry (LBMS) at UW-Madison.
Morgridge scientist named a ‘cool science image’ winner

via UW-Madison

Congratulations to Jiaye “Henry” He, a member of the Huisken Lab, for his second straight winning entry in the UW-Madison annual “Cool Science Image” awards.
Training tomorrow’s engineers

Since 2015, engineering students at the University of Wisconsin-Madison have teamed up with Morgridge Institute for Research engineers and clinicians at UW Hospital.
Biologist takes top prize in bioethics cartoon contest

Five prizes were awarded in the second annual Morgridge Ethics Cartooning Competition, a contest that invites participants to make a cartoon on any ethical issue arising in or from biomedical research. The competition drew 65 entrants from more than 32 different departments and programs at the University of Wisconsin-Madison and affiliated research institutions.
A Picture is Worth a Thousand Words

via Chan Zuckerberg Science Initiative

Imaging of molecules, cells and tissues is central to biomedical research and clinical practice, allowing scientists to understand and identify disease. Yet progress in the imaging field has been slowed by inadequate software and limited sharing of advanced microscopy methods. The CZI Imaging Scientists program aims to move the field of imaging forward by increasing collaboration between biologists and technology experts and improving the imaging tools that scientists use.
Have microscope, will travel: New tech project links Madison, Boston scientists

An invention designed to transform how and where high-powered research microscopes are deployed — and who gets to use them — will make its way from Madison this spring to the fertile biology labs of greater Boston.
The Role of the Student Engineer in Medicine and Innovation

via Xconomy

In a March 18 Xconomy opinion piece, Morgridge Fab Lab Director Kevin Eliceiri describes how a trifecta of engineering training, clinical experience and entrepreneurship is putting Wisconsin students in a great position for future success.
How to get young scientists thinking about ethics? Cartooning, say UW researchers

via The Cap Times

A biomedical research institute is prompting young scientists to think about the ethics of their research — not through a rulebook or a lecture, but with a cartooning contest.
Dietram Scheufele on #scicomm: What scientists can do to promote science and explain their work

In this Q&A, Scheufele shares information about the news environment, what it means for science communication, and what scientists can do to promote science and explain their work.
Seeing things more clearly, thanks to campus-wide microscopy effort

via UWMadScience

Give most kids a basic microscope and a leaf or a drop of pond water, and they are in awe of the, well, microscopic patterns and organisms they can now see. Give a cell biologist a transmission electron microscope (TEM), and they can understand how structures within cells are organized – and how changes in the structures contribute to diseases.
Taking new approaches to study lipid biology

Any budding scientist knows that oil and water don’t mix. However, for our largely water-filled cells to thrive, nature needs to devise clever ways to make and move around the lipids—fat and oil-like compounds—that comprise membranes and other key cellular parts.
13 years of stem cell summer camp

Every summer since 2007, students from some of the smallest high schools in Wisconsin have descended on the Morgridge Institute for Research for some big-time scientific immersion.
Expert panel explores gene-editing controversy at Crossroads of Ideas

In late 2018, a Chinese scientist dropped a bombshell when he announced the birth of the world’s first gene-edited twins, and the scientific community is still grappling with the aftermath and ethical implications.
2019 Ethics Cartooning Contest – Public Voting

The Morgridge Ethics Cartooning Competition invited entrants to make a cartoon on any ethical issue arising in or from biomedical research. Now, you can help choose the competition winners.
GrammaTech adds real world benchmarks to SWAMP

Software development and quality managers that are looking to measure the benefit of static analysis now have a platform to do just that. Real-world benchmarks are now available in the Software Assurance Marketplace (SWAMP).
Stem cells: Where are we going?

Together with the University of Wisconsin-Madison, we look back on 20 years of stem cell research and see where we’re going next. Catch up on what’s happened since James Thomson’s prescient prediction that stem cells “will change medicine, period.”
Metabolism scientist wins prestigious AAAS Fellowship

For Danielle Lohman, her passion for science policy began when she heard a PhD chemist speak at a career conference about the American Association for the Advancement of Science (AAAS) fellowship at the State Department in Washington, D.C.
New partnership will help fuel the next generation of scientists and explorers

An ambitious new partnership in Wisconsin will create, connect, and activate world-class content creators in science, instruction and media with teachers and learners across the state and the nation.
Conferences are Important for High School Students—Youth Apprentices and STEM Professional Development

via Promega Connections

Isabel Jones, Verona Area High School senior and second year YA, who works at the Morgridge Institute for Research, presented a scientific poster at one conference and spoke on a panel at another.
Scientists, ethicists slam decisions behind gene-edited twins

via Ars Technica

“There’s been very broad consensus that we shouldn’t be doing CRISPR on embryos yet.” Morgridge Institute bioethicist Pilar Ossorio speaks out about recent news of first human gene-edited babies.
Collaboration leads to ‘dream’ of artery bank

Just as blood banks are essential to medicine, the Thomson Lab hopes to see the advent of artery banks that give surgeons a better, readily available material to replace diseased arteries. The lab is using pluripotent stem cells to grow the cellular building blocks of the artery — endothelial and smooth muscle cells — and coax them into assembling into arteries that can grow and thrive in a majority of patients.
Out of left field: Thomson looks at discovery and the future of science

James Thomson, the UW-Madison biologist whose stem cell discovery 20 years ago opened fascinating and promising new avenues in science, took time to discuss his thoughts on the breakthrough and what the future holds for the field of regenerative medicine.
Summer science camp expands opportunities for Wisconsin’s rural schools

The Rural Summer Science Camp has seen more than 500 rural high school students and teachers since its inception in 2007. Campers learn about stem cell science, medical engineering, epigenetics, bioinformatics and more while engaging with and immersing themselves in the work of active researchers at the Morgridge Institute for Research and UW-Madison.
Improving the odds: Researchers develop novel device to study early stage of breast cancer

Imagine your chances of developing an invasive cancer were the same as a coin toss. Do you opt for aggressive treatments like surgery and chemotherapy, or do you take your chances that the cancer will never manifest?
Turning T cells into better cancer assassins

Alexandra Walsh, an assistant scientist in the lab of Morgridge medical engineer Melissa Skala, is leading a project to use non-invasive fluorescence imaging to identify and sort T cells for use in cancer immunotherapy treatments. The technology won a 2018 Innovation Award from the Wisconsin Alumni Research Foundation.
Best of the Fest: 2018 Wisconsin Science Festival in photos

We’ve collected some of our favorite moments from the 2018 Wisconsin Science Festival. Vote for your favorite photo and be entered to win some Morgridge prizes!
UW researchers, doctors trying to better predict preterm birth

via Wisconsin State Journal

Preterm births — which can lead to infant death or disability — are on the rise, accounting for nearly 400,000 of the country’s 4 million annual births. But doctors have a hard time figuring out which pregnant women are likely to deliver early.
Lunchroom leftovers make for an ‘eye-opening’ science project

via Wisconsin State Journal

This year the Wisconsin Society of Science Teachers and the Wisconsin Science Festival are partnering on a Statewide Science Challenge open to all K-12 schools. The 2018 challenge is called “Lunchroom Leftovers” and student teams are conducting detailed analyses of food waste in their school cafeterias.
Scientists seek to improve quality control for genome editing therapies in the eye

via UW-Madison

As gene editing therapies for macular degeneration and other visual disorders work their way into clinical trials, the University of Wisconsin–Madison is on the forefront of research into making sure they are safe and effective.
How microscopes are opening a door into an invisible universe brimming with life — Genius Moments

via Mashable

Meet Dr. Elizabeth Haynes and Jiaye “Henry” He. Their tiny zebrafish video just won first prize in the annual Nikon Small World in Motion Competition. It basically selects the coolest movies or time-lapse photos taken through a microscope.
Imaging the zebrafish, one cell at a time

A new imaging project at the Morgridge Institute for Research might be the biology equivalent of a 19th century expressionist painting. Think Van Gogh’s “Starry Night,” a constellation of tiny lines of color combining into a powerful image. Except the canvas of this research project will be a zebrafish, and the paint will be individual cells of a developing embryo.
Partnerships between universities, private sector working across Wisconsin

via Wisconsin Technology Council

At the UW-Madison, the progress of the Morgridge Institute for Research is another example. Partly financed with a $50-million gift from John and Tashia Morgridge of Cisco Systems fame, the private- non-profit biomedical research center is focused on novel strategies to improve human health.
Award Winning Videos Reveal The Weird And Beautiful Microscopic World

via Forbes

This week, Nikon announced the winners of the 2018 Nikon Small World in Motion contest. First prize went to Elizabeth Haynes and Jiaye “Henry” He of the University of Wisconsin-Madison for their mesmerizing time-lapse video of a zebrafish embryo growing its sensory nervous system over the course of 16 hours.
Award-Winning Microscopic Video of Growing Zebrafish Embryos Is Mesmerizing

via Gizmodo

A glowing, branching web slowly grows more and more tiny connections, with thin white tendrils reaching in to a black void. It looks like a fractal art piece. But in fact, it’s someone’s science research—the developing nervous system of a zebrafish embryo.
Morgridge, UW researchers win top prize in Nikon International Small World imaging contest

Henry He, a doctoral student at the Morgridge Institute for Research, and Liz Haynes, a postdoctoral fellow in the Department of Integrative Biology at the University of Wisconsin-Madison, won first place in the 2018 Nikon Small World in Motion Competition for a video depicting neural development in a zebrafish embryo.
Morgridge, Meriter research project targets the persistent risk of preterm birth

Of the approximately 4 million births in the United States each year, at least 400,000 of them still trigger a state of desperation in maternity wards. Parents, doctors and medical staff feel this way over the challenge of managing high-risk pregnancies.
Trio of Morgridge Institute medical researchers to speak at Sept. 25 Innovation Network luncheon

via Wisconsin Technology Council

Three scientists at the Morgridge Institute for Research will describe what brought them to Madison and how breakthroughs in medical engineering, regenerative biology and medical imaging will help save lives at the Tuesday, Sept. 25 Tech Council Innovation Network luncheon meeting in Madison.
Explore more than 200 events statewide at the Wisconsin Science Festival

From food science and viruses to data visualization and climate change, there’s something for everyone at the 2018 Wisconsin Science Festival (WSF), held this year from Oct. 11-14.
Chasing ghost particles with armies of computers

Scientists with the IceCube neutrino detection project, located on the South Pole and run by the University of Wisconsin-Madison, announced in July that they found the origin point of a cosmic neutrino in an energy-spewing black hole 4 billion light years from Earth. Scientists say the discovery will provide a fundamental new tool for seeing the unseeable in the universe.
Pushing toward personalized pancreatic cancer treatments

Melissa Skala and Paul Campagnola, a professor of biomedical engineering at UW-Madison, hope to make inroads toward improved drug therapies through a two-year National Institutes of Health Exploratory/Developmental Research Grant.
Metabolism investigator Jason Cantor joins Morgridge Institute, UW-Madison

Jason Cantor could describe himself as an engineer, biologist and biochemist, but don’t try to put his expertise into one box. Cantor, a scientist exploring the environmental influences on cancer cell metabolism, is launching a new lab in the Metabolism Theme at the Morgridge Institute and joining the UW-Madison departments of biochemistry and biomedical engineering.
Want to fight cyberthreats? Start with clean code

The SWAMP offers more than 30 open-source and commercial static code analysis tools fully integrated into its automated platform. A new classroom experiment represents an important front for the SWAMP as it aims to advance continuous assurance on software security.
Finding a weak link in the frightful parasite Schistosoma

The parasitic disease schistosomiasis is one of the developing world’s worst public health scourges. Researchers are searching for potential new targets by probing the cellular and developmental biology of the parasitic flatworm Schistosoma.
Lipid species offer insights into metabolic health

Two new Morgridge Institute for Research studies suggest the current tests, which measure the abundance of lipid classes, are insufficient. Rather, lipids identified and studied at the individual species level—instead of grouped in classes—may be better signatures of metabolic health.
‘Flamingo:’ High-powered microscopy coming to a scientist near you

Jan Huisken’s Morgridge team has developed a portable, shareable light sheet microscope. The project can be mailed to a lab anywhere in the world, configured remotely by Morgridge engineers, and run one to three months of experiments.
Stem cell summer camp inspiring early careers in science and technology

Every summer since 2007, students from some of the smallest high schools in Wisconsin descend on the Morgridge Institute for Research for the Morgridge Rural Summer Science Camp. Now, 12 years into the camp, organizers are finding it has been a difference-maker.
UW Carbone Cancer Center Study to look for ways to personalize therapy in colorectal cancer

via School of Medicine and Public Health

The study will use optical imaging techniques developed by Melissa Skala, a co-investigator at the Morgridge Institute, to monitor the evolution of 3D cancer tumor cultures over time.
HOSA students tackle tough subject

via Wisconsin State Journal

Dane County high school students visited the Skala Lab to tackle pancreatic cancer, the third-leading cause of cancer deaths in Wisconsin.
New effort gives teens the opportunity, tools to drive science programming

The newly-launched Discovery Teen Science Café gives Madison high school students the opportunity to research, plan and host events that connect them with scientists working on topics the students are most interested in.
Discovery Outreach teams up with Family Science Nights

Family Science Nights are hands-on science activities hosted by K-12 schools and community centers—and a growing grassroots effort at the University of Wisconsin-Madison is helping to connect scientists and educators with families and community members.
Morgridge Institute announces John W. and Jeanne M. Rowe Center for Research in Virology

The Morgridge Institute for Research is launching the John W. and Jeanne M. Rowe Center for Research in Virology, a new transformative research initiative made possible by the philanthropic support of John and Jeanne Rowe.
Morgridge metabolism fellowship seeks to strengthen the research network

A graduate fellowship launched this year by the Morgridge Institute for Research will help bring “fresh eyes” to the growing pursuit of metabolism research at UW-Madison.
Congratulations to our graduating students

With the semester winding down, we are thrilled to congratulate graduating students and research staff who are moving on and up. More than 110 undergraduate and graduate students, in addition to post-doctoral fellows, work across six biomedical research themes at the Morgridge Institute.
Immortal: An oral history of stem cell discovery

In November 1998, the journal Science published James Thomson’s groundbreaking work on embryonic stem cells. There has been 20 years of progress since the initial discovery spawned a new field of research, and tremendous potential exists for the future. We reached out to the people who lived it, and they shared the experiences in their own words. This is their story.
HTCondor powers Marshfield Clinic project on disease genetics

Using the equivalent of hundreds of years of computing time on HTCondor, a Marshfield Clinic scientist is compiling a database that will map genetic connections to more than 8,000 human diseases.
New imager identifies tissue types during surgery

via University of Wisconsin

OnLume, a spinoff from the University of Wisconsin–Madison, is continuing to develop its system for identifying tissue types during surgery. The company’s technology causes chemical labels to glow in the operating room.
Recap: Celebrating 20 Years of Stem Cell Science

On April 18 more than 170 scientists, researchers and supporters joined scientist o celebrate the 20th anniversary of the isolation of human embryonic stem cells.
Cryo-EM Expert Elizabeth Wright Joining Biochemistry to Direct New Facility

via UW Biochemistry

The University of Wisconsin–Madison Department of Biochemistry will welcome Elizabeth Wright in July as a faculty member and director of the department’s newly established cryo-electron microscopy (cryo-EM) facility.
Mentoring at Morgridge

When Ava VanDommelen was seven, she asked for her first microscope for Christmas. Now, at 17-years-old, she’s using microscopy to explore cancer tumors and the immune system at the Morgridge Institute for Research.
Two Morgridge scientists place in 2018 Cool Science Image Contest

Two scientists at the Morgridge Institute for Research—Jayhun Lee and Jiaye “Henry” He—were named winners in the 2018 Cool Science Image Contest, competing against more than 170 submitted images and videos.
Winner: Blue Sky Bracket Challenge

It’s your turn to pick the winners in the final head-to-head matchup of this March Madness-style bracket. Would you rather explore the mechanics of 3D printing or how viruses relate to cancer? You choose in the Blue Sky Science Bracket Challenge. Come back next week to support your favorite videos in the final championship! A winner will be crowned on April 9.
Ethics cartooning competition winners announced

Umair Khan, a UW-Madison graduate student working at the Morgridge Institute for Research, took the top prize in the inaugural Ethics Cartooning Competition.
SWAMP-in-a-Box can help turbo-charge software assurance

In the drive to reduce software security flaws, the Software Assurance Marketplace (SWAMP) at the Morgridge Institute for Research has enhanced its portable platform that brings a comprehensive suite of software assurance tools to the programmer’s desktop.
Fearless Science

In a new report, we meet the scientists driven to understand the mysteries of biology and alleviate human suffering from disease. Take a look inside as we explore science at the Morgridge Institute for Research.
The ‘Ice Road Truckers of science’ and why we need them

In an opinion piece published in The Hill, the nation’s leading news website on U.S. politics, Morgridge Institute for Research CEO Brad Schwartz and UW-Madison Chancellor Rebecca Blank argue that a renewed investment in basic research is essential to America’s economic progress.
New Pyle Chair honors Morgridge affiliate Joshua Coon

A new chair at the Morgridge Institute for Research takes aim at osteoarthritis, a debilitating and painful disease that affects more than 27 million Americans. Currently, osteoarthritis is largely treated with palliative care to help patients alleviate their symptoms.
An Achilles heel discovered in viruses could fuel new antiviral approaches

Scientists at the Morgridge Institute for Research have discovered a promising new target to fight a class of viruses responsible for health threats such as Zika, polio, dengue, SARS and hepatitis C.
Scholarly snowball: Deep learning paper generates big online collaboration

Bioinformatics professors Anthony Gitter and Casey Greene set out in summer 2016 to write a paper about the “state of the art” in deep learning for biomedicine, a hot new artificial intelligence field striving to mimic the neural networks of the human brain.
New stem cell method sheds light on a tell-tale sign of heart disease

While refining ways to grow arterial endothelial cells in the lab, a regenerative biology team at the Morgridge Institute for Research unexpectedly unearthed a powerful new model for studying a hallmark of vascular disease.
2018 Ethics Cartooning Contest – Public Voting

The first Morgridge Ethics Cartooning Competition invited entrants to make a cartoon on any ethical issue arising in or from biomedical research. Now, you can help choose the competition winners. Voting will be open until January 31, 2018.
Blue Sky Science: Could we use planarians to help us understand human regeneration?

Planarians are flatworms, and they’re masters of regeneration with virtually unlimited capacity to regenerate any missing tissue or body part lost to injury or aging.
Madison-based SWAMP and Synopsys join forces to educate the future cybersecurity workforce

The Software Assurance Marketplace (SWAMP) has partnered with Synopsys, an industry leader in software security and quality, to expand its suite of assurance tools in support of the academic community.
Blue Sky Science: Why is the sky blue?

Light from the sun comes in many different colors including colors we can see and some colors we can’t see. And just like sound waves or waves on the water, light travels in waves as well.
Cracking the code of coenzyme Q biosynthesis

Coenzyme Q (CoQ) is a vital cog in the body’s energy-producing machinery, a kind of chemical gateway in the conversion of food into cellular fuel. But six decades removed from its discovery, scientists still can’t describe exactly how and when it is made.
Blue Sky Science: How do you identify edible mushrooms?

There’s not one rule that applies to mushrooms. You have to know your biodiversity to know which species are edible and which species are not edible.
Blue Sky Science: How many molecules are in a cubic inch?

Molecules are formed by atoms bonding together, and there are many different types of molecules that you interact with every day. For example, water and sugar are both molecules.
Blue Sky Science: Why don’t joints bend both ways?

Structurally joints don’t bend both ways because there are physical components within their design that prevent or resist motion. This could be bone, such as the elbow joint, or it could be ligamentous restraint, such as in the knee.
Mastodons, brains, and a view of Mars: How the Wisconsin science festival helps bring kids and science together

Last weekend, excited young people darted about with a delirium I haven’t seen since the Pokémon craze. The University of Wisconsin-Madison was the home base for the Wisconsin Science Festival that included 54 communities, leaving every citizen within an hour’s drive of an event.
Blue Sky Science: How do beetles use camouflage?

Beetles are an extremely diverse group of insects on the planet. There are about a million or more described species of insects, that we know of so far, and of those about 400,000 are beetles.
Best of the Fest: Wisconsin Science Festival in photos

We’ve collected some of our favorite moments from the 2017 Wisconsin Science Festival, held Nov. 2-5 in Madison and across the state. Vote for your favorite photo and be entered to win some Morgridge prizes!
Measuring the molecules of life – Q&A with Josh Coon

Proteins are the workhorse molecules that perform all the functions in the cell and the body. Being able to detect and measure proteins is critical to figuring out basic biology, and the signature of diseases such as Alzheimer’s, cancer and diabetes. Josh Coon is creating technologies to do exactly that.
Regulating iron in the blood for optimal health – Q&A with Rick Eisenstein

Iron is an essential nutrient to human life, the element by which we regenerate red blood cells. Too little iron can cause serious problems such as anemia. But too much can be toxic, potentially causing blood clotting. Rick Eisenstein studies iron metabolism, with the goal of helping humans achieve the optimal balance for health.
Blue Sky Science: Why do hurricanes form where they do? Why Florida and not Wisconsin?

Hurricanes form near places like Florida and not further north like Wisconsin because they need some critical components to develop.
Blue Sky Science: Could scientists build a virtual brain and body for research?

To learn from a virtual body, it would need to be able to accurately simulate or predict how the body responds to internal and external changes.
New course brings storytelling techniques to science

via University of Wisconsin

A new course teaches early-career scientists how to communicate their work outside of the lab, and is designed to turn real research into engaging stories, visuals and presentations.
Blue Sky Science: Why do some animals go extinct while other species regenerate their populations?

Much depends on the circumstances in which the animals have become rare in the first place. It could be a big environmental change in the habitat, something affecting food, water, shelter or cover.
Morgridge ‘titans’ of healthcare

via Madison Magazine

Morgridge’s own James Thomson (founder of Cellular Dynamics) and Rock Mackie (founder of Tomotherapy) are listed among the top nine “healthcare titans” fueling the Madison economy.
Morgridge, UW scientists explore national security implications of gene editing

A trio of scientists from the University of Wisconsin-Madison and the Morgridge Institute for Research participated in an international think tank this month on the intersection of genome editing technology and national security.
WARF announces annual grant figures and Innovation Award winners

via University of Wisconsin

At a ceremony honoring several of the year’s most outstanding inventions, the Wisconsin Alumni Research Foundation (WARF) announced that it has granted the Morgridge Institute for Research $19 million in grants for the 2017-18 academic year.
Monsters of Morgridge

Not all monsters lurk in the closet, hide under the bed, or go bump in the night; in fact, they are all around us. In basic research, you can find tapeworms who thrive on the blood of their animal hosts – or the limb-generating axolotl, a water amphibian whose very name means “water monster.”
Blue Sky Science: How are stars (like the sun) formed?

A star is considered a sun if it’s in the center of a system with planets orbiting around it. Stars are formed in very large dark clouds. These dark clouds are made primarily of hydrogen and carbon monoxide.
Study Shows HPV Works Across Cellular Borders to Drive Cervical Cancer

via School of Medicine and Public Health

Human papillomavirus (HPV) and the hormone estrogen are both linked to the development of cervical cancers, but how they work together has remained unclear. A new study by University of Wisconsin-Madison researchers shows how the combination of two factors influences the local cervical environment and drives the progression of cancer development.
Blue Sky Science: Why do leaves change color in the fall?

September and October are the peak months for admiring fall foliage, the orange, yellow and red leaves. To understand why leaves change color, you have to start with the process of photosynthesis. All plants, including trees, have green leaves because of a compound called chlorophyll.
Morgridge, UW scientists played role in Nobel-winning gravitational wave discovery

Tuesday’s announcement of the Nobel Prize in Physics, awarded to researchers Rainer Weiss of the Massachusetts Institute of Technology and Kip Thorne and Barry Barish of the California Institute of Technology, bears Morgridge Institute for Research and University of Wisconsin System connections.
Discovery Incubator fosters innovation in science outreach

Innovation can come from anywhere, but often it’s when the right people are in the right place at the right time.
From moon rocks to flash talks, explore 100+ Wisconsin Science Festival events

Radio technology, astrobotany, dairy science and computer coding are just a handful of science topics to be explored at the 2017 Wisconsin Science Festival, held Nov. 2-5.
Blue Sky Science: Why does the moon have craters?

One reason the moon has craters because it gets hit by objects, small pieces of rocks that come from outer space. These are pieces of asteroids, comets that are flying around in the solar system.
Morgridge cartoon contest seeks to spark creative thinking on bioethics

Can you find the humor while searching for the ethical high ground? A new cartooning contest sponsored by the Morgridge Institute for Research will reward the most creative bioethical thinkers with up to $3,500 in cash prizes.
Blue Sky Science: How is a gummy bear made?

Gelatin is the basis of what makes a gummy bear a gummy bear, but we first start with sugar, corn syrup and water. Gelatin is thermoreversible, meaning that heat can turn it back into a liquid.
A novel data storage project unshackles microscopy from data overload

Jan Huisken teamed this summer with the Morgridge Institute computational technology team and technicians from storage platform company Dell EMC to create an end-run around the bottleneck. The team installed a storage system that creates a new intermediate 100-terabyte storage platform that will collect data straight from its origins at the microscope.
Blue Sky Science: How can milk make so many different products?

Milk can make many products because of its complex chemistry and history. Early humans used milk and had to experiment with various means to preserve it and its nutrition content over time.
Blue Sky Science: How does our brain think?

In order for your brain to think, you need nerve cells that can detect information about the outside world and can transmit that information to other nerve cells.
Blue Sky Science: How do fireflies glow?

When living creatures produce and emit light it’s called bioluminescence. The main reason fireflies glow is to find a mate, though they can also light up under other situations as a warning to others.
Blue Sky Science: How were the Madison lakes formed?

Before the last glaciation, which started about 30,000 years ago, there was a deep river valley that ran under where Lake Mendota and the other Madison lakes are now. A glacier moved into this area and slowly filled up the valley.
Blue Sky Science: How did dinosaurs evolve into birds?

Not all dinosaurs were big. In fact, the smallest ones are the ones that are still alive today. The one big question is: How exactly did flight evolve?
Blue Sky Science: How does science protect great works of art?

Art conservators can use X-rays and infrared technology to learn more about the structure of a painting, the paint layers and what happened to a painting over time.
Blue Sky Science: What is beyond Pluto?

There are many, many objects beyond Pluto, but where they came from and when they formed is a whole other question.
Creating the blueprints for new biofuels – Q&A with Tim Donohue

Earlier this month, the Great Lakes Bioenergy Research Center (GLBRC) received another major boost from the U.S. Department of Energy, receiving more than $250 million to conduct another five years of groundbreaking work on alternative fuels.
Stem cells, microfluidics and drug discovery headline high school science camp

For the last 11 years, high school students and teachers from rural communities in Wisconsin have journeyed to Madison to dig into stem cell science, learning from leading researchers in regenerative medicine.
Science Festival 2017: Revel in a Century of Public Broadcasting

The 2017 Wisconsin Science Festival on November 2-5 will celebrate one of the great scientific “firsts” that Wisconsin bestowed on the world — the birth of public radio — while gazing into the future of radio technology, including the search for extraterrestrial life.
Jerrod Buckner connects students to the wonders of science

Jerrod Buckner is the newest member of the Morgridge Institute for Research Outreach team. With his background in designing afterschool programs, Buckner is working to connect elementary and middle school students and their families to the wonder of science happening here at Morgridge and the University of Wisconsin-Madison.
Blue Sky Science: Why can eye color vary between siblings?

We all have genes in our body, and our genes carry DNA. Siblings can inherit various genes from their parents and they don’t always get the same ones.
Blue Sky Science: How does our immune system recognize bad from good?

Important cells for distinguishing between good and bad are T cells, and it’s estimated that there are approximately a trillion T cells in our body.
Stem cell advance brings bioengineered arteries closer to reality

New techniques developed at the Morgridge Institute for Research and the University of Wisconsin-Madison have produced, for the first time, functional arterial cells at both the quality and scale to be relevant for disease modeling and clinical application.
Blue Sky Science: What is pain tolerance and how does it work?

Pain is subjective and is different for every person who experiences it. There’s also different dimensions of pain including sensory, emotional and behavioral components.
Blue Sky Science: How do people learn to read?

From the science, researchers know a lot about how reading works, how children learn, the kinds of obstacles children encounter, and where teachers and classroom activities can make a difference.
Quality and collaboration, not growth, should drive research institutions

via STAT

The crux of the problem is that, over the years, many leaders of research institutions have treated research as a volume business and focused more on money and operational size than on the discovery of new knowledge.
Morgridge scientists illuminate structures vital to virus replication

In the fight against the viruses that invade everyday life, seeing and understanding the battleground is essential. Scientists at the Morgridge Institute have, for the first time, imaged molecular structures vital to how a major class of viruses replicates within infected cells.
Blue Sky Science: How do fireworks get their color and shape?

Fireworks, as you can tell from the name, involve fire. To get a fire you need fuel, oxygen and heat, and that’s true in fireworks also.
Model organisms: Peculiar creatures, big discoveries

From axolotls to zebrafish, this story explores some of science’s classic models, others more unusual, but all with potential for increasing our understanding of biology to improve human health.
2017 Rural Summer Science Camp spans Wisconsin landscape

For two weeks in July, more than 50 Wisconsin rural high school students and 10 teachers will converge on Madison to get a taste of stem cell science, rubbing elbows in labs with some of the world’s leading researchers in regenerative medicine.
Blue Sky Science: How does friction work?

Friction is a force that resists sliding motion between contacting surfaces. A bike, for example, has many instances of friction.
Blue Sky Science: Why do cats have rough tongues?

Cats have functional barbs or papillae on their tongue made of keratin, the same material that nails and our hair is made out of. They’re very rigid little barbs that face backwards.
Blue Sky Science: How and why do our teeth fall out?

It’s normal and natural for baby teeth to fall out. Usually kids start to get loose teeth between ages 5 and 7. The new permanent tooth begins eating the root of the baby tooth away, that baby tooth becomes loose, and then the permanent tooth eventually pushes it out and erupts into its place.
American Family, Boys & Girls Club partner to expand Saturday Science

More children and families can take a monthly plunge into hands-on science, thanks to an American Family Insurance and Boys & Girls Club of Dane County partnership to provide transportation to and from Saturday Science events at the Discovery Building.
Blue Sky Science: How do the sun and rain make rainbows?

Rainbows are really cool because they’re a blend between art and science. It required a number of scientists to actually explain how they form, including Isaac Newton.
Blue Sky Science: How do plants grow if there’s no sunlight?

Plants need sunlight for a process that we call photosynthesis. Plants are what we call autotrophs, meaning they create their own food or energy to grow.
Blue Sky Science: How many galaxies are in the universe?

Counting the number of galaxies in the universe is tough, because we can’t see all of the galaxies in the universe. At a certain point, distant galaxies disappear from our field of view.
Blue Sky Science: What is water scarcity?

Water scarcity is essentially when there’s not enough water in the right place at the right time. Even in places that seem water-rich, it may not be clean enough for its intended purposes.
Blue Sky Science: What’s the difference between types of 3D printer filaments?

3D printing is the process by which we make a piece layer by layer, and the various forms of 3D printing differ in how they make each layer. Extrusion-based printing, or fused deposition modeling, uses filaments. It takes a raw material and extrudes it through a die to create a long strand That’s what a filament is.
Blue Sky Science: How does a curveball curve?

The rule to remember for curveballs: whichever way the front face of the ball is spinning will be the direction in which it curves. The effect is more dramatic with ping pong balls and tennis balls because of their lower mass compared to baseballs.
You may also like … Algorithms that improve drug discovery

Anthony Gitter, a Morgridge investigator and assistant professor of biostatistics and medical informatics, says the goal will be to create machine learning tools that dramatically reduce the time and cost associated with screening compounds for therapeutic relevance.
Pagliarini earns distinguished early career honor from Protein Society

Dave Pagliarini, lead investigator of metabolism for the Morgridge Institute for Research and associate professor of biochemistry at the University of Wisconsin-Madison, is being recognized for major early-career achievement by The Protein Society.
Blue Sky Science: How are robots and humans similar?

Robots can be similar to people, but they aren’t necessarily so. People create the robots and can choose what aspects of functionality and design are important, but there are some benefits you get out of similarity.
Morgridge researcher scores in cancer research ‘lightning round’

Melissa Skala, a Morgridge Institute for Research investigator in medical engineering, won a highly competitive award from the nonprofit organization Stand Up to Cancer at its annual 2017 summit January in Santa Monica.
Blue Sky Science: Is the biofuel process a complete cycle?

The production of biofuels starts by growing plants out in a field or forest. All of the biomass represented in those plants essentially comes through photosynthesis.
Failure isn’t fatal: A favor to the future

Dr. Stuart Firestein, author of “Failure: Why Science Is So Successful” and professor at Columbia University, brings attention to the virtues of courage and patience when advising young investigators on how to handle failure at the beginning of their career.
Blue Sky Science: Why is there gravity on Earth but not in space?

There’s actually gravity pretty much everywhere. But why do we feel gravity more here on the surface of the Earth instead of in space when astronauts appear weightless?
‘KinderMining:’ Tackling big data sets by keeping things simple

With about 100 lines of code, a Morgridge Institute for Research team has unleashed a fast, simple and predictive text-mining tool that may turbo-charge big biomedical pursuits such as drug repurposing and stem cell treatments.
Blue Sky Science: How does saving a file or image to a hard drive work?

A hard disk drive contains a circular shiny silver disk, similar to a CD or DVD but much smaller. This disk is coated with a magnetic material, and information is stored by magnetizing very tiny pieces of this surface.
Blue Sky Science: Why do fresh cheese curds squeak?

When cheese is manufactured, the milk is clotted and some of the water removed. You end up with a curd, a tough structure where the proteins in the cheese form a mesh.
Blue Sky Science: How much does a human brain typically weigh?

The human brain includes 100 billion neurons, or brain cells, and is an ever-changing organ.
Jan Huisken: Building a better, smarter microscope

As the medical engineering lead at Morgridge, Huisken will continue his innovations in “smart microscopy”.
Blue Sky Science: How are cells created?

New cells are created from existing cells through a process referred to as the cell cycle. One cell can make a copy of itself and form two new daughter cells.
Study shows stem cells fiercely abide by innate developmental timing

The mystery of what controls the range of developmental clocks in mammals — from 22 months for an elephant to 12 days for a opossum — may lie in the strict time-keeping of pluripotent stem cells for each unique species.
Blue Sky Science: How do rockets get past Earth’s atmosphere?

Rockets encounter most of the resistance when they’re near the Earth’s surface. The higher up they get, the thinner the air gets, and the resistance pushing against the rocket gets lower.
High-throughput computing plays pivotal role in knee biomechanics research

Darryl Thelen, professor in mechanical engineering and biomedical engineering at the University of Wisconsin-Madison, conducts research with this notion in mind while using computational models of the musculoskeletal system and high-throughput computing resources to refine knee surgical procedures.
Jose Maria Ayuso Dominguez: A Man of Many Names and Talents

If there were two words that described Jose Dominguez they would be: radiating enthusiasm. It’s easy to see his incredible passion and positivity for his research and life.
What we can learn from hibernation – Q&A with Hannah Carey

Hannah Carey, a UW-Madison professor of comparative biosciences, uses hibernating mammals as models to study extreme changes in physiology and nutrition that occur on a seasonal basis. Carey discusses this remarkable process and its potential to impact human health by improving trauma care.
Blue Sky Science: How do bees make honey?

Most bee species do not make honey, but those that do—as you might guess—are specifically called honey bees.
Blue Sky Science: How does electricity move through wires?

It’s a complicated process, but there are charges inside wires and these charges can be acted on by an electric field. They can move through the wire in something that’s called an electric current.
Tapping the ‘wild collaboration’ within biomedical engineers

By partnering with the Morgridge Institute for Research, BME landed internationally recognized optical imaging pioneers Melissa Skala and Jan Huisken to their new faculty ranks.
Blue Sky Science: Can brain injuries sustained while playing sports be fully recovered from?

A concussion is defined as a traumatic blow to the head coupled with some kind of altered consciousness. Some people refer to it as seeing stars, getting your bell rung. People may feel disoriented for a period of time.
Blue Sky Science: How does virtual reality work?

A broad definition says virtual reality is the idea of combining the physical world and the artificial world in such a way that the two are indistinguishable. How could technology provide all of the sensory sensations or different ways that people see, feel and hear the world such that the artificial and physical are blended together?
Chris Barry: Exploring the mystery of developmental clocks

Why does it take about nine months for humans to fully develop from conception to birth, compared to 22 months for an elephant, or just three weeks for the world’s most-studied mammal, the mouse?
Blue Sky Science: How does the moon affect the tides?

The tides are the result of the moon exerting its gravitational force on the ocean and bulging it both toward and away from the moon. The tide is higher, the ocean is higher, at the location closest to the moon and on the opposite side of the Earth.
Blue Sky Science: Why do some viruses cause cancer?

Infectious agents—both bacterial and viral—are responsible for about 25 percent of all human cancers. The virus infection does not by itself cause cancer, but can interfere with a cell’s normal maintenance of things.
Blue Sky Science: How do animals evolve and get new traits?

All those different types of life are products of selection based on behavioral or physical traits.
Blue Sky Science: How long would it take a tree to grow in space?

It’s a complicated question because, while researchers have grown spruce seedlings on the International Space Station, they haven’t grown full-size trees. Using knowledge of how trees operate on Earth, scientists can guess what’s going to happen when they’re grown in space.
Blue Sky Science: Why are snowflakes individually unique?

Two important factors influence the shape of snowflakes. One is the ambient temperature, and the other is humidity. A snowflake needs to grow under the condition of a super saturated environment.
Blue Sky Science: How does the epiglottis distinguish between water, food and air?

Swallowing is one of the most obvious functions the epiglottis serves, because it hoods over the airway, or larynx, when you eat and drink. When you swallow, the muscles in your throat respond by pulling the voice box up and underneath the tongue, and the epiglottis is pulled to cover over the larynx.
Blue Sky Science: Can all mosquitos transmit viruses like Zika?

Not all mosquitos can transmit the Zika virus, and that’s the case with any mosquito-borne pathogen. There are about 3,000 species of mosquitos in the world and only a handful—about 150—are considered vectors of pathogens, capable of spreading viruses.
Brad Schwartz: Measure what matters in science

In a guest blog for the Nov. 22 online edition of Scientific American, Morgridge Institute CEO Brad Schwartz writes about a challenge research institutions face in conveying the true societal value of research.
Blue Sky Science: Why do we have freckles?

Freckles are composed of an ingredient called melanin, which protects against damage caused by UV light. Your body makes melanin to protect itself from sun damage.
OnLume receives SBIR support for image-guided surgery

OnLume received the $300,000 Phase I SBIR grant through the National Cancer Institute (NCI) at the National Institutes of Health (NIH) for the development of imaging and lighting systems for transient lighting in fluorescence image-guided surgery.
Blue Sky Science: How does thunder form?

Thunder is formed by the intense heating produced by lightning. The thunder you hear is made up of vibrations that travel as sound waves through the air until they reach your ear.
Blue Sky Science: Why do chickens lay different-colored eggs?

Genetics is the simple answer to why chickens lay different-colored eggs. Some chickens lay white shell eggs and some lay brown shell eggs, similar to the way hair color varies in people.
Blue Sky Science: How do temperature and wind affect traffic noise?

In terms of temperature, sound waves move faster in warm air and slower in cold air. So as sound moves through the atmosphere, some parts of the wave will be moving faster than the rest.
Morgridge ‘prototype pathway’ yields a novel organ transplant technology

Organ transplantation has come a long way from its early days in the mid-twentieth century. But even with major medical advances, there’s still an admittedly familiar factor at play: ice.
Can artery ‘banks’ transform vascular medicine?

The prospect of creating artery “banks” available for cardiovascular surgery, bypassing the need to harvest vessels from the patient, could transform treatment of many common heart and vascular ailments.
Blue Sky Science: How do we make robots?

Imagine building a robot in three stages.
Blue Sky Science: How does a 3D printer make color?

3D printing involves making an object layer by layer. There are many 3D printing techniques, and they all differ in how each layer is constructed. Each type of printer has a different opportunity or mechanism for adding color.
Blue Sky Science: What is a solar flare?

A solar flare is a release of magnetic energy from the sun. The energy is stored as a magnetic field around the sun, and then it is released with energetic particles and waves coming from the solar surface.
Getting personal with pancreatic cancer

Oncologists are struggling to improve the grim survival rates of pancreatic cancer, which are especially frustrating in an era that is making good progress on other cancer fronts. “I think
Blue Sky Science: What is cedar-apple rust disease?

Cedar-apple rust is one of several plant diseases that are all caused by different species of a fungus called gymnosporangium. All of these diseases are referred to as gymnosporangium rust diseases.
From physics to fitness, athletes in science challenge minds and bodies

From Rosalind Franklin to Edwin Hubble, history has shown that athleticism and scientific prowess are not mutually exclusive traits.
Mateusz Manicki: Collaboration breeds scientific opportunity

In order to understand the biochemical underpinnings of disease, it is imperative to shrink down to the molecular level. It’s this mentality that steered Mateusz Manicki all the way from Poland’s Gdansk University to Madison, Wisconsin to study mitochondrial proteins. Manicki will be using mass spectrometry resources to better understand the functionality of cells contributing to a given disease.
Blue Sky Science: Why (and for how long) do butterflies stay in a cocoon?

Caterpillars start out as very small, tiny creatures. In the beginning they eat lots of food—just like the book “The Very Hungry Caterpillar”—and get bigger and bigger.
Blue Sky Science: What precautions are recommended in regards to Zika virus and pregnancy?

Many people travel to areas that have active, ongoing transmission of Zika virus disease.
Thomson honored for stem cell research legacy

Wisconsin biotechnology advocacy organization BioForward honored two giants in state biomedical innovation — stem cell research pioneer James Thomson and entrepreneur Ralph Kauten — for their scientific and business achievement during its annual summit September 27 in Madison.
Blue Sky Science: Why do we have wisdom teeth?

Wisdom teeth are the third set of permanent molars that typically come in between the ages of 17 and 25. Some people don’t form them anymore, and a lot of people that do need to have wisdom teeth taken out.
Curious research: Endowed chair honors developmental biologist Phil Newmark

Newmark, who joined the Regenerative Biology research focus at the Morgridge Institute and the Department of Zoology this summer, is also serving as the first recipient of the Burnell R. Roberts Chair in Regenerative Biology.
Blue Sky Science: Why do the northern and southern lights only appear near the poles?

The formation of the northern and southern lights—known as aurora borealis and aurora australis—begins with solar flares from the sun. The solar flares eject groups of electrons from the sun that act as a wind and flow toward the Earth.
Early development reveals axolotl mysteries

In the amphibian world, the axolotl is the replacement-parts king. This endangered Mexican salamander serves as its own NAPA store for lost body parts, able to fully regenerate limbs, tail, heart, spine and eyes — making it a model of curiosity for regenerative biologists.
Blue Sky Science: Why do some logs float and some sink?

Whether an object floats or sinks in water is determined by the ratio of its weight compared to its volume. If an object of a certain volume weighs more than an equal volume of water, it sinks because the water can’t hold it up. If an object weighs less than an equal volume of water, it floats because the water can support its weight.
Tech investment spurs Alzheimer’s research

The Laboratory of Biomolecular Mass Spectrometry (LBMS), launched in summer 2015, accelerates the university’s ability to apply this powerful technology to high-impact projects, says Joshua Coon, UW-Madison professor of chemistry and biomolecular chemistry and LBMS director.
Play us a song: the (Hyper)piano man

Christopher Taylor has the hands of a musician, his fingers most at home striking the keys of a piano, and an analytical mind honed by years of computer programming. Now after tackling his latest endeavor, Taylor can also call himself an engineer, a builder, a maker.
Science arcade night, storytelling headline 2016 Wisconsin Science Festival

From arcade games to storytelling to stargazing, the 2016 Wisconsin Science Festival, held Oct. 20-23, will feature something for everyone across 200-plus events.
Blue Sky Science: Could we harness energy in space for use on Earth?

When thinking about collecting energy from a source in space, the natural answer is the sun.
Blue Sky Science: How are moons created?

Anything that orbits a planet is a moon, and moons can form in several different ways.
Blue Sky Science: What are bacteria?

Bacteria are amazing single-celled, simple organisms. They’re found everywhere on the planet in all sorts of environments from your gut to the soil to the Arctic and Antarctic.
Sarah Erickson-Bhatt: Bridge to a breakthrough

When Sarah Erickson-Bhatt lost her mother to breast cancer before she began undergraduate study in 2001, the physics student determined that fighting cancer would become her life’s work.
Blue Sky Science: How do toys affect a baby’s development?

Virtually every theory of child development says that play is crucial to development in every way. It impacts cognitive development, social and emotional development, as well as language development.
Course aims to prepare scientific postdocs for leadership

Postdoctoral trainees at the University of Wisconsin-Madison have an opportunity to refine their professional leadership skills through a six-session course starting in fall 2016.
Blue Sky Science: Could we use viruses to fight cancer?

Cancer is, essentially, cells that have started to grow uncontrollably and stop behaving like normal cells. Viruses are an attractive treatment tool because they, by their very nature, are manipulators of cells. It may be possible to reengineer viruses in a way that could either stop cancers from growing or kill cancer cells.
Mitochondrial maps reveal new connections to poorly understood diseases

Mitochondria are the engines that drive cellular life, but these complex machines are vulnerable to a wide range of breakdowns, and hundreds of their component parts remain a functional mystery.
Blue Sky Science: Why do beavers, rabbits have the same kind of teeth?

Squirrels, beavers, chipmunks and rabbits all have similarly-shaped teeth, because all of those animals have teeth that continually grow throughout their lives.
Blue Sky Science: Are there wormholes that lead to other galaxies?

Wormholes can exist within the framework of general relativity, Albert Einstein’s theory that governs how space-time interacts with matter in our universe.
Plumbing the possibilities of ‘seeing around corners’

The Morgridge Institute for Research and University of Wisconsin-Madison researchers are working to optimize a camera capable of a slick optical trick: Snapping pictures around corners.
John Durant helping light science festival fireworks nationwide

Durant is director of the Massachusetts Institute of Technology (MIT) Museum, where he began in 2005 after decades of leadership at major British science museums. This summer, Durant joined the scientific advisory board of the Morgridge Institute for Research, where he will give guidance to an outreach program that attracts more than 30,000 people annually to the Discovery Building.
Blue Sky Science: What determines the melting or boiling point of a substance?

Before we can answer that question, we need to know first: What is a solid? What’s a liquid? What’s a gas?
Jing Fan joins Morgridge Institute metabolism theme

Can we fight cancer by targeting its metabolism, essentially starving tumors of the nutrients they need to survive? It’s one of the intriguing big-picture questions in the research field of Jing Fan, a new investigator in the Morgridge Institute for Research metabolism theme.
Blue Sky Science: How long does it take a GMO product to grow?

Genetically modified organisms, or GMOs, refer to any plant or animal that has been genetically modified by humans.
Blue Sky Science: Does an earthquake ever form a new tectonic plate?

Most earthquakes occur when a geological fault, fractures within the earth’s crust, slip and release energy. Individual faults, some of which form the tectonic plate boundaries, build up strain over decades and centuries to eventually break in large earthquakes.
Madison College students think outside the shell in stem cell project

Since chick embryos lack a developed immune system, scientists are able to engraft other types of cells — including mouse and human cells — into the friendly 3D confines of the embryo and study their behavior. Under the right conditions, the introduced cells can thrive.
Blue Sky Science: Could we make a living creature using only stem cells?

Stem cells are special cells inside your body that can multiply indefinitely, or make copies of themselves. They can also differentiate, meaning they can become every cell type that’s present in your body.
NIH leader headlines summit on big data and health

Phillip Bourne, who since 2014 has served as the NIH’s first associate director for data science, will give the keynote address June 30 at the annual research retreat for Wisconsin’s own big-data center, called the Center for Predictive Computational Phenotyping (CPCP).
Blue Sky Science: What makes a mammal? Is an octopus a mammal?

It’s a great guess, but an octopus is not a mammal. An octopus is an invertebrate animal, which means it has no spine. More specifically, an octopus is a cephalopod, like squid and cuttlefish. They’re some of the smartest invertebrates.
Linectra and Xemex tie for second in manufacturing category of statewide competition

Two Morgridge-affiliated inventors tied for second place in the advanced manufacturing category of this year’s statewide Governor’s Business Plan Contest.
Three Morgridge-affiliated inventors are state business plan finalists

The Morgridge Institute for Research will be well represented in this year’s statewide Governor’s Business Plan Contest, with three of the 13 finalists having direct ties to the Morgridge Medical Engineering research group.
Blue Sky Science: How did dinosaurs go extinct?

When it comes to dinosaur extinction, the working idea is what’s called the bolide impact. This is the hypothesis that a meteorite came to the surface of the Earth, hit the Earth, and led to the extinction of the dinosaurs.
Blue Sky Science: How are waterfalls made?

It basically it takes four things to make a waterfall.
Regeneration pioneer to join Morgridge Institute, UW-Madison faculty

Phil Newmark, a developmental biologist studying the mysteries of how the body regenerates damaged tissue, will join the Morgridge Institute for Research and the University of Wisconsin-Madison Department of Zoology
Blue Sky Science: Why is it difficult to predict which flu vaccine will be most effective?

A vaccine is meant to train your immune system to recognize a virus so it can fight off that virus if you ever come in contact with it.
Pagliarini ‘energized’ by White House visit

It’s not every day someone gets the chance to stroll through the East Wing of the White House, snapping photos and checking out its famous Blue Room and Red Room. Dave Pagliarini experienced that and more during his trip to the nation’s capital May 5-6 to receive his Presidential Early Career (PECASE) award.
Can cybersecurity crack the undergraduate curriculum?

In a time when million-dollar security breaches of household name corporations regularly make headlines and complicate lives, computer science undergraduates at America’s universities remain surprisingly underexposed to basic cybersecurity tactics.
Blue Sky Science: What’s going on in the brain when people sleepwalk?

When we sleep we go through different types of sleep stages. You have slow-wave sleep, which is like your deep sleep, and then there’s dream sleep, which is called REM sleep.
Community, business leader Mary Burke joins Morgridge Board of Trustees

Mary Burke will bring more than two decades of experience in Wisconsin business, civic and educational leadership to the Morgridge Institute for Research as a new member of its Board of Trustees.
Collagen imaging: Bridging the gap between microscopy and the clinic

When it comes to diagnosing breast cancer and predicting how the disease will progress in a patient, current practice is seeing a gap between the imaging information scientists can get from a high resolution microscope and the lower resolution images typically gathered in the clinical setting.
Blue Sky Science: How do hovercrafts work?

To understand how a hovercraft works, we have to understand a few things about matter. We, and all ordinary matter, are made of little tiny things called atoms and clumps of atoms called molecules.
Blue Sky Science: How did animals evolve from water to land?

Water to land evolution is a complex question, and one that is still actively researched today.
Blue Sky Science: Why do supercomputers have to be so big?

We need supercomputers because scientists are doing really awesome work that requires lots of computing time. For some of this work, if we weren’t using supercomputing to break up tasks and make processing faster, it would take years or decades to complete.
Blue Sky Science: Do plants produce nectar every day?

Not all plants produce nectar, only plants that are visited by animal-type pollinators. Plants that are wind pollinated, for example, will not produce nectar.
#100miles4research: Kopietz celebrates 19 years cancer-free

The Kopietz Family (L-R): Lucas, Courtni, Jeff, Teresa, and Tyler. Courtni and her dad Jeff are soon embarking on a 100-plus mile trek across Portugal to celebrate Courtni’s 19th year cancer-free. All proceeds donated to #100miles4research campaign will benefit the Morgridge Institute for Research.
Blue Sky Science: When will a human trip to Mars be possible?

We could send humans to Mars whenever we want to. We have the technology to do it today, though we would need to build new rockets that use that technology.
CAREER award to explore dynamics of biology

Anthony Gitter remembers the mental spark when listening to a recent talk about the discovery of so-called “precocious cells” — a tiny group of cells that lead an advance charge against infection.
Blue Sky Science: Can people have the abilities of animals?

This question brings up all kinds of interesting issues about who we are as humans and how we compare to other animals.
Blue Sky Science: How does someone get two different-colored eyes?

When the eye color, or iris color, is different between the two eyes, the condition is called iris heterochromia.
Blue Sky Science: How did scientists find out about electricity?

Electricity is a complex topic that drives the world as we know it today, from Thomas Edison’s iconic light bulb to the satellites that enable our cell phones. Fundamentally, electricity is just the presence and flow of electric charge.
Blue Sky Science: How do some plants grow without dirt?

The principal purpose of soil is to provide mineral nutrition for the plant.
Morgridge virology team leader wins distinguished Hilldale Award

Paul Ahlquist, leader of the Morgridge Institute virology team, is one of four recipients of the Hilldale Award for distinguished contributions to teaching, research and service.
New Morgridge research team leader foresees era of ‘smart microscopes’

Jan Huisken, a scientist who develops tools to image biology in its unaltered natural state, will lead the medical engineering focus area at the Morgridge Institute for Research and help catalyze a campus-wide multi-scale imaging initiative.
High Throughput Computing helps LIGO confirm Einstein’s last unproven theory

A few years ago, a global team of scientists parlayed decades of research into the discovery of the Higgs boson, a subatomic particle considered a building block of the universe. A humble software program called HTCondor churned away in the background, helping analyze data gathered from billions of particle collisions.
Blue Sky Science: How do scientists find fossils?

There are a number of steps that go into a researcher finding a fossil, something I spend a majority of my summer doing. First you have to figure out what kind of fossil you want to find.
Blue Sky Science: What’s the science of leap year?

2016 is a leap year, meaning we insert an extra day, February 29, into the calendar. We do this once every four years in order to keep our calendar aligned with the Earth’s seasons.
Pagliarini earns presidential recognition for research on mitochondria

Dave Pagliarini, Director of Metabolism at the Morgridge Institute for Research and Associate Professor of Biochemistry at the University of Wisconsin-Madison, has received the U.S. government’s highest honor for scientists in the early stages of their careers.
Blue Sky Science: Do you think there’s life on other planets?

The short answer to the question is that we don’t know. The closest planets to Earth are located millions of miles away, so it’s very difficult to go off and find evidence directly.
Blue Sky Science: How is spider silk made?

Spiders have silk-producing glands in their bodies, specifically in their abdomen. In these glands they have the chemical components already put together to produce silk, but it’s in a liquid form.
Q&A with Discovery Audio-Visual Coordinator Alan Ruby

If you’re one of the thousands of people annually who participate in meetings at the Discovery Building, chances are you’ve benefited from the skills and commitment of Alan Ruby and his team.
Melissa Skala: Follow the Light to Better Cancer Treatment

Skala’s research problems focus on cancer detection and treatment, and her expertise in light-based, optical imaging is giving clinicians revolutionary new tools for the fight. Skala will be bringing her talents this summer from Vanderbilt University to the Morgridge Institute for Research and the University of Wisconsin-Madison, as a Morgridge investigator and professor of Biomedical Engineering (BME).
Blue Sky Science: Why can people eat the same diet or take the same medication and have different outcomes?

This is a question scientists are still trying to figure out. We know that it has to do with the specific genetic makeup, and everyone has slight differences in metabolism.
Blue Sky Science: What and where is the Yahara watershed?

The Yahara watershed is a geographic area in south central Wisconsin. It is comprised of about 370,000 people and 359 square miles home to the city of Madison, the University of Wisconsin-Madison, and this chain of lakes we refer to as the Yahara lakes.
Morgridge, campus partner to power up ‘mass spec’ potential

The Morgridge Institute for Research, as part of its Metabolism Initiative, is working with a University of Wisconsin-Madison team to greatly expand the scope of “mass spec” applications on campus. A new resource housed in the UW-Madison Biotechnology Center brings together a multi-million dollar investment in mass spectrometry tools from multiple sources to form a central repository to tackle large-scale investigations.
Blue Sky Science: How many species of snakes are there?

There are more than 3,400 species of snakes worldwide, and they exist on every continent except Antarctica. We have about 50 snake species in the United States and 21 different snake species in the state of Wisconsin.
Blue Sky Science: Can we use stem cells to treat brain injury or neurological disorders?

The simple answer to the question is yes. It is possible to regenerate parts of the brain with stem cells, just like we can in other organs.
Blue Sky Science: Does space go on forever?

We really don’t know if space goes on forever. The universe is big enough that we can’t see all of it for a number of reasons. And there are ways that we could live in a space that doesn’t go on forever, but still has no actual edge to it.
Blue Sky Science: How do we hear?

Sounds reach our ears from different locations and first travel through the ear into the ear canal. Then tiny bones inside the middle ear end up vibrating and pushing on a small window. This then gets a special membrane inside our ear to vibrate.
Blue Sky Science: Why do hissing cockroaches hiss?

Madagascar hissing cockroaches and some of their relatives can produce an audible hissing noise that almost sounds like a cat hissing.
Blue Sky Science: How does your brain form memories?

The first step in forming a memory is called encoding, and encoding starts with perception. If you remember back to the first time you met your best friend, you encoded or perceived a lot of information about them.
Blue Sky Science: Why can dogs hear a dog whistle but people can’t?

Humans can hear sounds in a range from about 20 hertz to 23 kilohertz at the upper range of their hearing ability. The hearing range of dogs is almost double that.
Blue Sky Science: Why do some colors make you feel emotions?

Over the years you’ve learned to associate certain colors, certain shapes, certain things that you see with specific emotions.
Blue Sky Science: What is a neutrino?

In high school you learn that matter is made of atoms, atoms are made of electrons and nuclei, and nuclei contain neutrons and protons. That’s a basic picture of matter, but it’s an incomplete one. Missing in that picture is a full particle called neutrinos.
Blue Sky Science: What is machine learning?

Machine learning is an area of computer science that focuses on building computer programs that help machines learn by example. This is similar to the way young children learn about the world around them.
Scheufele named to gene editing panel

Dietram Scheufele, professor of life sciences communication at UW-Madison and Morgridge Institute for Research affiliate, will serve on a national panel examining the implications of human genome editing.
New stem cell process increases therapeutic potential

Researchers from the Morgridge Institute for Research and the Murdoch Children’s Research Institute (MCRI) in Australia have devised a way to dramatically cut the time involved in reprogramming and genetically correcting stem cells, an important step to making future therapies possible.
Blue Sky Science: How are crystals formed?

The word “crystal” comes from the Greek “krystallos,” meaning clear ice. A crystal is defined as a solid material consisting of a three-dimensional periodic ordering of atoms, molecules or ions. Crystals form by a process called crystallization that signifies a transition from chaos to perfection.
Blue Sky Science: How fast could a human theoretically run?

The current world record for running speed is held by Usain Bolt at roughly 28 miles per hour, and it’s difficult to imagine running faster.
Morgridge Institute, Morgridge Center expand hands-on science activities in South Madison

Afterschool Expeditions, a program in which elementary and middle school students engage in structured, hands-on science activities at the Discovery Building, has become an integral part of the outreach programming produced by WARF and the Morgridge Institute for Research in partnership with Science Alliance and numerous UW-Madison groups.
Blue Sky Science: How do we identify new species from fossils?

When we try to identify different species in nature today, we usually think of that question in terms of interbreeding. We look at different populations, whether they look different or the same, and ask, do they ever interbreed with each other or encounter each other in nature?
Blue Sky Science: What is gene editing?

Gene editing involves changing the sequence of letters in the DNA. Researchers like to edit genes so they can understand the function of them, particularly genes that relate to various types of disorders that physicians have seen in the clinic. We can use this information to generate new hypotheses of how genes influence diseases.

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