The Summer Science Workshop Series kicks off June 23 with 106 students and 29 educators from 21 schools in the Wisconsin Rural Schools Alliance and seven sites in the Upward Bound program that focuses on underrepresented and first-generation pre-college students. Learn more >
The Summer Science Workshop Series kicks off June 23 with 106 students and 29 educators from 21 schools in the Wisconsin Rural Schools Alliance and seven sites in the Upward Bound program that focuses on underrepresented and first-generation pre-college students.
Five prizes were awarded in the fourth annual Ethics Cartooning Competition, addressing the social impacts of scientific research, like issues on public health and communication during the COVID-19 pandemic.
Neuroendocrine cancers grow so slowly they often evade detection before it’s too late. By mimicking that slow growth in the lab, the Melissa Skala Lab hopes to speed up the creation of more effective treatments.
President Biden has laid out a vision for elevating the importance of science in this country. But it’s up to all scientists to help educate Americans about the benefits of science and the discoveries that have changed our world.
President Biden has laid out a vision for elevating the importance of science in this country. But it’s up to all scientists to help educate Americans about the benefits of science and the discoveries that have changed our world.
Multiple COVID-19 vaccines are available, but some people are on the fence about getting their shot. Approaching a conversation with vaccine-hesitant friends and family may be challenging. Three scientists and public health experts spoke to more than 250 members during a Fearless Science Seminar Series.
Ashley Cortes Hernandez is excited to bring Latinx representation to the team in hopes of making STEM more accessible to underrepresented communities in her new role as assistant outreach coordinator for Discovery Outreach.
The Jason Cantor Lab at Morgridge is utilizing a new cell culture medium to ask how critical genes are to the survival and reproduction of human cells under different growth conditions. The technique could have important ramifications for the treatment of human diseases.
Citing presentations from the Feb. 24 Morgridge Institute Fearless Science Seminar, CBS 58 in Milwaukee reported that new booster vaccines are in development that will specifically target COVID 19 variants that have recently emerged around the world.
For more than ten years, the Field Trip Program has brought students and teachers to Madison for a day of activity and exploration. But when the COVID-19 pandemic shuttered on-campus activity, the Discovery Outreach Team had to get creative.
The Discovery Outreach team is growing an iceberg. The visible part above the water is made up of the tens of thousands of people of all ages who participate in programs each year. And the mass below the surface contains hundreds of Wisconsin scientists, researchers and experts who are adding their voice to science engagement.
Stem cell pioneer James Thomson is leading a potentially transformational project to develop a safe and functional cell-based artificial artery that could be pulled from medical inventories and used by vascular surgeons.
Morgridge Institute spinoff company OnLume had a banner year in 2020, receiving Food and Drug Administration (FDA) approval, meeting its venture funding goals and launching its first clinical trial with a California company. And they are getting expert feedback from UW Health physicians on their groundbreaking fluorescence imaging device.
A few of our Morgridge alumni shared thoughts on their research experience at the Morgridge Institute, their plans moving forward and their warm shoutouts to some of the people who helped them along the way.
Kayla Huemer, a graduate of the Morgridge Fab Lab and alumna of UW-Madison, is tackling machine learning at Stanford. Huemer brings a depth of experience in engineering and design which she honed during her time in the BerbeeWalsh Prototype Pathway.
Morgridge postdoctoral fellow Jayhun Lee is a lead author in a new study that outlines the first-ever cell atlas of the tropical parasite schistosome, an advance that could provide new alternatives for fighting a disease that impacts more than 200 million people globally.
Wisconsin students and teachers took part in an online session called “My Story in Science So Far: From Voices Underrepresented in Science,” as part of a field trip to the Wisconsin Science Festival in October.
Researchers at the Morgridge Institute and UW-Madison want to ensure that pancreatic cancer treatment options are accessible to all — regardless of race, ethnicity, or insurance status — so that patients can make the most informed decisions regarding their care.
With every heartbeat comes a rhythmic pulse that helps blood flow through the body. Understanding this pulsatile flow can offer insights on the impacts of blood vessel development and cardiovascular disease. New research uses an “organ-on-a-chip” model to study pulsatile flow in a more biologically relevant way.
Engineers are well-equipped to address the world’s development challenges, but good engineering alone is not enough. We need the emerging field of ‘global engineering,’ argues Kevin Eliceiri, a Morgridge medical engineering investigator, and Rebecca Alcock, a recent alumna of the UW-Madison graduate program in biomedical engineering.
A Morgridge imaging study of macrophages — immune cells that are important to human health, but paradoxically can help some cancers grow and spread — is offering better ways to understand these cells and target them with immunotherapies.
Researchers at the Morgridge Institute for Research, Albany Medical Center, and UW-Madison assembled a profile of biological molecules that correlated not only with COVID-19 infection, but with disease severity. More target molecules will likely be found as others analyze the data, which is freely available online.
The 10th annual Wisconsin Science Festival was held virtually for the first time this past weekend, highlighted by a virtual road trip. Children of all ages could view tours, panels, lessons and so much more virtually, allowing them to travel all over the state without ever leaving their homes.
OnLume Surgical, a spinoff company originating from Morgridge Institute research, has received a 2020 Wisconsin Innovation Award. The company, which develops precise fluorescence for image-guided surgery, was chosen for the award from more than 400 nominees.
National Science Foundation leader Fleming Crim will give a talk on Friday, October 16 at 2 p.m. titled NSF Broader Impacts: Fostering Connections to Expand the Societal Benefits of Basic Research, as a part of the Wisconsin Science Festival’s speaker series.
Morgridge Institute spinoff company OnLume Surgical, a medical device company developing novel imaging systems for use during surgery, was recognized as one of the ten (10) finalists for the 2020 Wisconsin Innovation Awards.
UW-Madison and the Morgridge Institute for Research will get $22.7 million over six years from the National Institutes of Health to create a national center for imaging techniques that flash-freeze biological molecules to let scientists see a better picture of their function.
As health officials move closer to developing safe vaccines against COVID-19, Morgridge virology expert Paul Ahlquist argues for the need for patience and trust during what will be the largest vaccination effort in more than 70 years.
A national research initiative announced today will place the University of Wisconsin-Madison at the forefront of a revolution in imaging fostered by cryo-electron microscopy and cryo-electron tomography.
“A mill won’t last long if there is no mine, but a mill is required to get the products to the market,” Morgridge investigator Melissa Skala said during a Wisconsin Technology Council webinar. “What I find so powerful about the Endless Frontier Act is that it supports both the mine and the mill to benefit innovation across the spectrum.”
After ten years as a student, mentor, and engineer in the Morgridge Institute, Ben Cox is finishing his postdoctoral fellowship in the BerbeeWalsh Prototype Pathway and heading to the University of Chicago Polsky Center for Entrepreneurship and Innovation.
Why is it that some COVID-19 patients become extremely ill and die, while others experience only mild symptoms? A new study uses mass spectrometry, RNA sequencing, and machine learning to explore the molecular traits that might influence the severity of the disease.
When Morgridge investigator Jing Fan thinks about metabolism, she is focused on the complicated network of biochemical reactions. Her lab has been working on understanding metabolism in a quantitative, systematic way.
Morgridge researchers uncovered in a new study how schistosomes, parasitic flatworms that infect more than 200 million people in the tropics, trick the host’s immune system and continue producing eggs for decades.
Computer Sciences Professor Miron Livny has been selected for two prestigious IEEE awards: the 2020 IEEE Technical Committee on Distributed Processing (TCDP) Award for Outstanding Technical Achievement and a 2020 IEEE TDCP ICDCS High Impact Paper Award.
A team of developmental biologists at the Morgridge Institute for Research has discovered a means by which schistosomes, parasitic worms that infect more than 200 million people in tropical climates, are able to outfox the host’s immune system.
Morgridge scientists John Brubacher, Anthony Gitter, Brian Bockelman, Ben Cox and Katie Overmyer, joined Gabriella Gerhardt on July 22 for a Fearless Science webinar about rapidly applying technology and methods to answer COVID-19 questions.
The scientific community’s shift on wearing masks to fight the pandemic tells us something important about the scientific process. Science can get things wrong, but the constant push for new knowledge — combined with an ability to admit and correct mistakes — should always prevail.
UW-Madison announced Tuesday that scientists from the university and the Morgridge Institute for Research have been able to capture “strikingly improved images” of virus group, which could help aid in the creation of antiviral drugs and treatment for COVID-19.
For the first time, scientists at the Morgridge Institute for Research have generated near atomic resolution images of a major viral protein complex responsible for replicating the RNA genome of a member of the positive-strand RNA viruses.
Morgridge bioethicist in residence Pilar Ossorio commented in STAT about the growing problem of hospitals not disclosing to patients how many clinical decisions are now being made with artificial intelligence.
Writing in The Hill, Morgridge CEO Dr. Brad Schwartz provides insight and context for scientific discovery as a foundation for economic prosperity. As the United States looks to science to help us get past the COVID-19 pandemic, we would be well advised to also look back.
The novel coronavirus presented a significant hurdle for Discovery Outreach team—how do you bring science to rural students during a pandemic? Now in its 14th year, the Rural Summer Science Camp is celebrating a new milestone: an entirely digital experience.
The deadliest cases of COVID-19 often arise in patients with a variety of pre-existing conditions, known to medicine as “comorbidity.” A Morgridge Institute for Research project will investigate those disease relationships in the search for new drug treatments.
The Morgridge Institute for Research Board of Trustees voted on Wednesday to elect Carl Gulbrandsen, emeritus managing director of the Wisconsin Alumni Research Association (WARF), as the new chairman of the 20-member Morgridge Institute board.
The Morgridge Institute for Research Board of Trustees voted on Wednesday to elect Carl Gulbrandsen, emeritus managing director of the Wisconsin Alumni Research Association (WARF), as the new chairman of the 20-member Morgridge Institute board.
In light of the COVID-19 pandemic, Paul Ahlquist and Tony Gitter joined CEO Brad Schwartz in a webinar where they discussed COVID-19 and the broader context of viral pandemics and how we respond to them.
Melissa Skala, a University of Wisconsin-Madison associate professor of biomedical engineering, and collaborators have used an approach called optical metabolic imaging (OMI) to effectively assess that heterogeneity and related treatment responses in organoids created with tissues from patients with breast cancer and pancreatic cancer.
A Morgridge Institute for Research project intended to shed light on planarians — remarkable flatworms capable of almost limitless regeneration — is being repurposed to focus on the novel coronavirus causing COVID-19.
An Albany Med physician who has been caring for COVID-19 patients during the pandemic is partnering with the Morgridge Institute and UW-Madison to study why some patients experience COVID-19 more severely than others.
Morgridge virology investigator Anthony Gitter, an assistant professor of biostatistics and medical informatics at UW-Madison, has co-developed a software tool called Manubot to help orchestrate a rapid expert assessment of COVID-19 diagnostics and therapeutics.
Morgridge Affiliate Dominique Brossard and Morgridge Investigator Joshua Coon are 2020 recipients of Kellett Mid-Career Awards, given by the Wisconsin Alumni Research Foundation every year to recognize mid-career excellence.
Congratulations to the graduating students and research staff as they move onward and upward. A few of these students and staff shared about their time at the Morgridge Institute, their accomplishments and their plans for what’s next.
In the center of the COVID-19 pandemic, many hospitals are racing to maintain quality care for patients with severe disease while facing a shortage of resources and limited understanding of the novel coronavirus.
Bioethicist Pilar Ossorio says the world could be at risk of sacrificing essential knowledge for fighting COVID-19 and future deadly viruses if the COVID-19 response is not accompanied by sound research.
Charlotte Kanzler, a first-year graduate student in the UW-Madison Cellular and Molecular Biology program and a member of the Phil Newmark lab at Morgridge, took the top prize in the third annual Ethics Cartooning Contest.
Tim Grant, a cryo-electron microscopy pioneer, joins the Morgridge Institute this month as the newest investigator. Grant joins a growing collaboration at UW-Madison where he will use cryo-EM to help biologists see the structure of molecules within cells.
The Morgridge Institute for Research is part of a multi-institution research project to develop a device that improves muscle tissue healing for serious injuries, using a combination of artificial intelligence, bioelectronics, and regenerative medicine.
As of March 18, the Discovery Building, home of the Morgridge Institute for Research, will be closed to the public. All public events in the building are canceled. Visit here for important COVID-19 updates.
High-throughput computing facilitated at the Morgridge Institute is helping scientists explore one of the mysteries of human consciousness: How the brain processes information while we are under anesthesia or asleep.
Danielle Lohman, a former member of the Pagliarini Lab and a UW-Madison alumna, talks about her first year working in the Department of State. Lohman is one of six Ph.D scientists to receive a AAAS Science and Technology Policy Fellowship.
A new, small-scale study published in Nature this month seeks to determine whether regular urine collection and analysis of the thousands of telling, changing indicators in our pee can reliably serve up information about a person’s health.
HHMI reports on the Newmark Lab’s discovery and purification of a substance made by rotifers that can paralyze the worms that cause schistosomiasis, a dangerous infection that affects 200 million people worldwide.
The Phillip Newmark Lab has isolated a natural chemical capable of paralyzing the parasitic worm schistosome, opening the door to new ways to combat a neglected tropical disease that sickens more than 240 million people.
At the Morgridge Institute for Research in the Discovery Building on the UW–Madison campus, David Green’s granddaughter — U/S. Sen. Tammy Baldwin — met the scientists who are continuing his early study of metabolism science, in hopes of breakthroughs that will help treat or reverse numerous diseases.
Forward-thinking science and childhood memories came full circle on Wednesday for U.S. Sen. Tammy Baldwin, who visited a lab at the Morgridge Institute for Research that is carrying on the inspired legacy of her grandfather, David E. Green.
As 2019 Nobel Prize announcements unfold, Morgridge CEO Brad Schwartz reflected on his all-time favorite winner. “Howard Temin represented what society expects from us and had the characteristics that make society willing to fund our work,” Schwartz wrote in Scientific American. “People want scientists who get up every morning committed to finding the truth.”
Panels on Oct. 17 and 18 during the Wisconsin Science Festival will examine representation and inclusion in science and science in entertainment and the arts. Both afternoon panels will take place in the Discovery Building.
Peter Favreau, a postdoctoral researcher at the Morgridge Institute for Research, discusses how the use of Optical Microscopy is helping to create individualized effective cancer treatments based on each patient’s tumor cells.
The 2019 Wisconsin Science Festival, held Oct. 17-20, will feature more than 220 events statewide and include everything from fossil exploration and robotic engineering to animal encounters and the science of Star Wars.
In the game against an essentially unlimited pool of virus threats, humanity is seriously outmatched. The Ahlquist Lab is working to develop broad-spectrum antivirals, solutions that will target many viruses at once.
The Morgridge Institute’s project to capture early developmental timing of humans “in a dish” was included in The Scientific American’s “Best Science GIFs” feature. This weekly feature highlights the most amazing short video clips produced in the world of science.
Tom Still, president of the Wisconsin Technology Council, focused his statewide business column on July 21 on a novel eye research partnership between the Morgridge Institute and Medical College of Wisconsin.
Morgridge Institute metabolism investigator Dave Pagliarini will receive the 2020 Earl and Thressa Stadtman Young Scholar Award from the American Society for Biochemistry and Molecular Biology (ASBMB). The award honors outstanding scholars with ten years or fewer of postdoctoral experience.
The Morgridge Rural Summer Science Camp, where rural high school students and teachers take a deep dive into science research over the course of a week, is expanding and offering a third week of camp thanks to new support from a National Science Foundation (NSF) project.
Welcome to Masters of Microscopy: The People Behind the Lens, where we showcase and celebrate the individuals who are the heart of the Nikon Small World competitions. They are scientists, artists, researchers, educators and everyday curious individuals who uncover the fascinating microscopic world around us.
Our portable, shareable microscope, called Flamingo, offers a chance for biologists who have a crazy idea to reach out to us do some great research — and for us to build a custom instrument to solve unique questions in biology.
Congratulations to the graduating students and research staff who will be moving onward and upward. A few of these students and staff shared about their time at the Morgridge Institute, their accomplishments and their plans for what’s next.
Scientists at the Morgridge Institute are working toward a dream of creating artery banks with readily-available material to replace diseased arteries during surgery. Recent work highlights highlights a better way to grow smooth muscle cells, putting the science one step closer to that goal.
Dave Pagliarini, associate professor of biochemistry and director of the Morgridge Institute for Research’s Metabolism Theme, studies mitochondria — ubiquitous organelles essential for cellular metabolism. His lab integrates classic biochemistry with large-scale methodologies to systematically define the functions of uncharacterized mitochondrial proteins and to establish the detailed mechanisms that drive disease-related mitochondrial pathways.
Five prizes were awarded in the second annual Morgridge Ethics Cartooning Competition, a contest that invites participants to make a cartoon on any ethical issue arising in or from biomedical research. The competition drew 65 entrants from more than 32 different departments and programs at the University of Wisconsin-Madison and affiliated research institutions.
Imaging of molecules, cells and tissues is central to biomedical research and clinical practice, allowing scientists to understand and identify disease. Yet progress in the imaging field has been slowed by inadequate software and limited sharing of advanced microscopy methods. The CZI Imaging Scientists program aims to move the field of imaging forward by increasing collaboration between biologists and technology experts and improving the imaging tools that scientists use.
An invention designed to transform how and where high-powered research microscopes are deployed — and who gets to use them — will make its way from Madison this spring to the fertile biology labs of greater Boston.
In a March 18 Xconomy opinion piece, Morgridge Fab Lab Director Kevin Eliceiri describes how a trifecta of engineering training, clinical experience and entrepreneurship is putting Wisconsin students in a great position for future success.
Give most kids a basic microscope and a leaf or a drop of pond water, and they are in awe of the, well, microscopic patterns and organisms they can now see. Give a cell biologist a transmission electron microscope (TEM), and they can understand how structures within cells are organized – and how changes in the structures contribute to diseases.
Any budding scientist knows that oil and water don’t mix. However, for our largely water-filled cells to thrive, nature needs to devise clever ways to make and move around the lipids—fat and oil-like compounds—that comprise membranes and other key cellular parts.
In late 2018, a Chinese scientist dropped a bombshell when he announced the birth of the world’s first gene-edited twins, and the scientific community is still grappling with the aftermath and ethical implications.
Software development and quality managers that are looking to measure the benefit of static analysis now have a platform to do just that. Real-world benchmarks are now available in the Software Assurance Marketplace (SWAMP).
Together with the University of Wisconsin-Madison, we look back on 20 years of stem cell research and see where we’re going next. Catch up on what’s happened since James Thomson’s prescient prediction that stem cells “will change medicine, period.”
For Danielle Lohman, her passion for science policy began when she heard a PhD chemist speak at a career conference about the American Association for the Advancement of Science (AAAS) fellowship at the State Department in Washington, D.C.
Just as blood banks are essential to medicine, the Thomson Lab hopes to see the advent of artery banks that give surgeons a better, readily available material to replace diseased arteries. The lab is using pluripotent stem cells to grow the cellular building blocks of the artery — endothelial and smooth muscle cells — and coax them into assembling into arteries that can grow and thrive in a majority of patients.
James Thomson, the UW-Madison biologist whose stem cell discovery 20 years ago opened fascinating and promising new avenues in science, took time to discuss his thoughts on the breakthrough and what the future holds for the field of regenerative medicine.
The Rural Summer Science Camp has seen more than 500 rural high school students and teachers since its inception in 2007. Campers learn about stem cell science, medical engineering, epigenetics, bioinformatics and more while engaging with and immersing themselves in the work of active researchers at the Morgridge Institute for Research and UW-Madison.
Imagine your chances of developing an invasive cancer were the same as a coin toss. Do you opt for aggressive treatments like surgery and chemotherapy, or do you take your chances that the cancer will never manifest?
Alexandra Walsh, an assistant scientist in the lab of Morgridge medical engineer Melissa Skala, is leading a project to use non-invasive fluorescence imaging to identify and sort T cells for use in cancer immunotherapy treatments. The technology won a 2018 Innovation Award from the Wisconsin Alumni Research Foundation.
Preterm births — which can lead to infant death or disability — are on the rise, accounting for nearly 400,000 of the country’s 4 million annual births. But doctors have a hard time figuring out which pregnant women are likely to deliver early.
This year the Wisconsin Society of Science Teachers and the Wisconsin Science Festival are partnering on a Statewide Science Challenge open to all K-12 schools. The 2018 challenge is called “Lunchroom Leftovers” and student teams are conducting detailed analyses of food waste in their school cafeterias.
As gene editing therapies for macular degeneration and other visual disorders work their way into clinical trials, the University of Wisconsin–Madison is on the forefront of research into making sure they are safe and effective.
Meet Dr. Elizabeth Haynes and Jiaye “Henry” He. Their tiny zebrafish video just won first prize in the annual Nikon Small World in Motion Competition. It basically selects the coolest movies or time-lapse photos taken through a microscope.
A new imaging project at the Morgridge Institute for Research might be the biology equivalent of a 19th century expressionist painting. Think Van Gogh’s “Starry Night,” a constellation of tiny lines of color combining into a powerful image. Except the canvas of this research project will be a zebrafish, and the paint will be individual cells of a developing embryo.
At the UW-Madison, the progress of the Morgridge Institute for Research is another example. Partly financed with a $50-million gift from John and Tashia Morgridge of Cisco Systems fame, the private- non-profit biomedical research center is focused on novel strategies to improve human health.
This week, Nikon announced the winners of the 2018 Nikon Small World in Motion contest. First prize went to Elizabeth Haynes and Jiaye “Henry” He of the University of Wisconsin-Madison for their mesmerizing time-lapse video of a zebrafish embryo growing its sensory nervous system over the course of 16 hours.
A glowing, branching web slowly grows more and more tiny connections, with thin white tendrils reaching in to a black void. It looks like a fractal art piece. But in fact, it’s someone’s science research—the developing nervous system of a zebrafish embryo.
Henry He, a doctoral student at the Morgridge Institute for Research, and Liz Haynes, a postdoctoral fellow in the Department of Integrative Biology at the University of Wisconsin-Madison, won first place in the 2018 Nikon Small World in Motion Competition for a video depicting neural development in a zebrafish embryo.
Of the approximately 4 million births in the United States each year, at least 400,000 of them still trigger a state of desperation in maternity wards. Parents, doctors and medical staff feel this way over the challenge of managing high-risk pregnancies.
Three scientists at the Morgridge Institute for Research will describe what brought them to Madison and how breakthroughs in medical engineering, regenerative biology and medical imaging will help save lives at the Tuesday, Sept. 25 Tech Council Innovation Network luncheon meeting in Madison.
Scientists with the IceCube neutrino detection project, located on the South Pole and run by the University of Wisconsin-Madison, announced in July that they found the origin point of a cosmic neutrino in an energy-spewing black hole 4 billion light years from Earth. Scientists say the discovery will provide a fundamental new tool for seeing the unseeable in the universe.
Melissa Skala and Paul Campagnola, a professor of biomedical engineering at UW-Madison, hope to make inroads toward improved drug therapies through a two-year National Institutes of Health Exploratory/Developmental Research Grant.
Jason Cantor could describe himself as an engineer, biologist and biochemist, but don’t try to put his expertise into one box. Cantor, a scientist exploring the environmental influences on cancer cell metabolism, is launching a new lab in the Metabolism Theme at the Morgridge Institute and joining the UW-Madison departments of biochemistry and biomedical engineering.
The SWAMP offers more than 30 open-source and commercial static code analysis tools fully integrated into its automated platform. A new classroom experiment represents an important front for the SWAMP as it aims to advance continuous assurance on software security.
The parasitic disease schistosomiasis is one of the developing world’s worst public health scourges. Researchers are searching for potential new targets by probing the cellular and developmental biology of the parasitic flatworm Schistosoma.
Two new Morgridge Institute for Research studies suggest the current tests, which measure the abundance of lipid classes, are insufficient. Rather, lipids identified and studied at the individual species level—instead of grouped in classes—may be better signatures of metabolic health.
Jan Huisken’s Morgridge team has developed a portable, shareable light sheet microscope. The project can be mailed to a lab anywhere in the world, configured remotely by Morgridge engineers, and run one to three months of experiments.
Every summer since 2007, students from some of the smallest high schools in Wisconsin descend on the Morgridge Institute for Research for the Morgridge Rural Summer Science Camp. Now, 12 years into the camp, organizers are finding it has been a difference-maker.
The newly-launched Discovery Teen Science Café gives Madison high school students the opportunity to research, plan and host events that connect them with scientists working on topics the students are most interested in.
Family Science Nights are hands-on science activities hosted by K-12 schools and community centers—and a growing grassroots effort at the University of Wisconsin-Madison is helping to connect scientists and educators with families and community members.
The Morgridge Institute for Research is launching the John W. and Jeanne M. Rowe Center for Research in Virology, a new transformative research initiative made possible by the philanthropic support of John and Jeanne Rowe.
With the semester winding down, we are thrilled to congratulate graduating students and research staff who are moving on and up. More than 110 undergraduate and graduate students, in addition to post-doctoral fellows, work across six biomedical research themes at the Morgridge Institute.
In November 1998, the journal Science published James Thomson’s groundbreaking work on embryonic stem cells. There has been 20 years of progress since the initial discovery spawned a new field of research, and tremendous potential exists for the future. We reached out to the people who lived it, and they shared the experiences in their own words. This is their story.
OnLume, a spinoff from the University of Wisconsin–Madison, is continuing to develop its system for identifying tissue types during surgery. The company’s technology causes chemical labels to glow in the operating room.
The University of Wisconsin–Madison Department of Biochemistry will welcome Elizabeth Wright in July as a faculty member and director of the department’s newly established cryo-electron microscopy (cryo-EM) facility.
When Ava VanDommelen was seven, she asked for her first microscope for Christmas. Now, at 17-years-old, she’s using microscopy to explore cancer tumors and the immune system at the Morgridge Institute for Research.
Two scientists at the Morgridge Institute for Research—Jayhun Lee and Jiaye “Henry” He—were named winners in the 2018 Cool Science Image Contest, competing against more than 170 submitted images and videos.
It’s your turn to pick the winners in the final head-to-head matchup of this March Madness-style bracket. Would you rather explore the mechanics of 3D printing or how viruses relate to cancer? You choose in the Blue Sky Science Bracket Challenge. Come back next week to support your favorite videos in the final championship! A winner will be crowned on April 9.
In the drive to reduce software security flaws, the Software Assurance Marketplace (SWAMP) at the Morgridge Institute for Research has enhanced its portable platform that brings a comprehensive suite of software assurance tools to the programmer’s desktop.
In a new report, we meet the scientists driven to understand the mysteries of biology and alleviate human suffering from disease. Take a look inside as we explore science at the Morgridge Institute for Research.
In an opinion piece published in The Hill, the nation’s leading news website on U.S. politics, Morgridge Institute for Research CEO Brad Schwartz and UW-Madison Chancellor Rebecca Blank argue that a renewed investment in basic research is essential to America’s economic progress.
A new chair at the Morgridge Institute for Research takes aim at osteoarthritis, a debilitating and painful disease that affects more than 27 million Americans. Currently, osteoarthritis is largely treated with palliative care to help patients alleviate their symptoms.
Bioinformatics professors Anthony Gitter and Casey Greene set out in summer 2016 to write a paper about the “state of the art” in deep learning for biomedicine, a hot new artificial intelligence field striving to mimic the neural networks of the human brain.
While refining ways to grow arterial endothelial cells in the lab, a regenerative biology team at the Morgridge Institute for Research unexpectedly unearthed a powerful new model for studying a hallmark of vascular disease.
The first Morgridge Ethics Cartooning Competition invited entrants to make a cartoon on any ethical issue arising in or from biomedical research. Now, you can help choose the competition winners. Voting will be open until January 31, 2018.
The Software Assurance Marketplace (SWAMP) has partnered with Synopsys, an industry leader in software security and quality, to expand its suite of assurance tools in support of the academic community.
Coenzyme Q (CoQ) is a vital cog in the body’s energy-producing machinery, a kind of chemical gateway in the conversion of food into cellular fuel. But six decades removed from its discovery, scientists still can’t describe exactly how and when it is made.
Structurally joints don’t bend both ways because there are physical components within their design that prevent or resist motion. This could be bone, such as the elbow joint, or it could be ligamentous restraint, such as in the knee.
Last weekend, excited young people darted about with a delirium I haven’t seen since the Pokémon craze. The University of Wisconsin-Madison was the home base for the Wisconsin Science Festival that included 54 communities, leaving every citizen within an hour’s drive of an event.
We’ve collected some of our favorite moments from the 2017 Wisconsin Science Festival, held Nov. 2-5 in Madison and across the state. Vote for your favorite photo and be entered to win some Morgridge prizes!
Proteins are the workhorse molecules that perform all the functions in the cell and the body. Being able to detect and measure proteins is critical to figuring out basic biology, and the signature of diseases such as Alzheimer’s, cancer and diabetes. Josh Coon is creating technologies to do exactly that.
Iron is an essential nutrient to human life, the element by which we regenerate red blood cells. Too little iron can cause serious problems such as anemia. But too much can be toxic, potentially causing blood clotting. Rick Eisenstein studies iron metabolism, with the goal of helping humans achieve the optimal balance for health.
A trio of scientists from the University of Wisconsin-Madison and the Morgridge Institute for Research participated in an international think tank this month on the intersection of genome editing technology and national security.
At a ceremony honoring several of the year’s most outstanding inventions, the Wisconsin Alumni Research Foundation (WARF) announced that it has granted the Morgridge Institute for Research $19 million in grants for the 2017-18 academic year.
Not all monsters lurk in the closet, hide under the bed, or go bump in the night; in fact, they are all around us. In basic research, you can find tapeworms who thrive on the blood of their animal hosts – or the limb-generating axolotl, a water amphibian whose very name means “water monster.”
A star is considered a sun if it’s in the center of a system with planets orbiting around it. Stars are formed in very large dark clouds. These dark clouds are made primarily of hydrogen and carbon monoxide.
Human papillomavirus (HPV) and the hormone estrogen are both linked to the development of cervical cancers, but how they work together has remained unclear. A new study by University of Wisconsin-Madison researchers shows how the combination of two factors influences the local cervical environment and drives the progression of cancer development.
September and October are the peak months for admiring fall foliage, the orange, yellow and red leaves. To understand why leaves change color, you have to start with the process of photosynthesis. All plants, including trees, have green leaves because of a compound called chlorophyll.
Tuesday’s announcement of the Nobel Prize in Physics, awarded to researchers Rainer Weiss of the Massachusetts Institute of Technology and Kip Thorne and Barry Barish of the California Institute of Technology, bears Morgridge Institute for Research and University of Wisconsin System connections.
Can you find the humor while searching for the ethical high ground? A new cartooning contest sponsored by the Morgridge Institute for Research will reward the most creative bioethical thinkers with up to $3,500 in cash prizes.
Jan Huisken teamed this summer with the Morgridge Institute computational technology team and technicians from storage platform company Dell EMC to create an end-run around the bottleneck. The team installed a storage system that creates a new intermediate 100-terabyte storage platform that will collect data straight from its origins at the microscope.
Before the last glaciation, which started about 30,000 years ago, there was a deep river valley that ran under where Lake Mendota and the other Madison lakes are now. A glacier moved into this area and slowly filled up the valley.
Earlier this month, the Great Lakes Bioenergy Research Center (GLBRC) received another major boost from the U.S. Department of Energy, receiving more than $250 million to conduct another five years of groundbreaking work on alternative fuels.
For the last 11 years, high school students and teachers from rural communities in Wisconsin have journeyed to Madison to dig into stem cell science, learning from leading researchers in regenerative medicine.
The 2017 Wisconsin Science Festival on November 2-5 will celebrate one of the great scientific “firsts” that Wisconsin bestowed on the world — the birth of public radio — while gazing into the future of radio technology, including the search for extraterrestrial life.
Jerrod Buckner is the newest member of the Morgridge Institute for Research Outreach team. With his background in designing afterschool programs, Buckner is working to connect elementary and middle school students and their families to the wonder of science happening here at Morgridge and the University of Wisconsin-Madison.
New techniques developed at the Morgridge Institute for Research and the University of Wisconsin-Madison have produced, for the first time, functional arterial cells at both the quality and scale to be relevant for disease modeling and clinical application.
The crux of the problem is that, over the years, many leaders of research institutions have treated research as a volume business and focused more on money and operational size than on the discovery of new knowledge.
In the fight against the viruses that invade everyday life, seeing and understanding the battleground is essential. Scientists at the Morgridge Institute have, for the first time, imaged molecular structures vital to how a major class of viruses replicates within infected cells.
For two weeks in July, more than 50 Wisconsin rural high school students and 10 teachers will converge on Madison to get a taste of stem cell science, rubbing elbows in labs with some of the world’s leading researchers in regenerative medicine.
It’s normal and natural for baby teeth to fall out. Usually kids start to get loose teeth between ages 5 and 7. The new permanent tooth begins eating the root of the baby tooth away, that baby tooth becomes loose, and then the permanent tooth eventually pushes it out and erupts into its place.
More children and families can take a monthly plunge into hands-on science, thanks to an American Family Insurance and Boys & Girls Club of Dane County partnership to provide transportation to and from Saturday Science events at the Discovery Building.
3D printing is the process by which we make a piece layer by layer, and the various forms of 3D printing differ in how they make each layer. Extrusion-based printing, or fused deposition modeling, uses filaments. It takes a raw material and extrudes it through a die to create a long strand That’s what a filament is.
The rule to remember for curveballs: whichever way the front face of the ball is spinning will be the direction in which it curves. The effect is more dramatic with ping pong balls and tennis balls because of their lower mass compared to baseballs.
Anthony Gitter, a Morgridge investigator and assistant professor of biostatistics and medical informatics, says the goal will be to create machine learning tools that dramatically reduce the time and cost associated with screening compounds for therapeutic relevance.
Dave Pagliarini, lead investigator of metabolism for the Morgridge Institute for Research and associate professor of biochemistry at the University of Wisconsin-Madison, is being recognized for major early-career achievement by The Protein Society.
Robots can be similar to people, but they aren’t necessarily so. People create the robots and can choose what aspects of functionality and design are important, but there are some benefits you get out of similarity.
Melissa Skala, a Morgridge Institute for Research investigator in medical engineering, won a highly competitive award from the nonprofit organization Stand Up to Cancer at its annual 2017 summit January in Santa Monica.
Dr. Stuart Firestein, author of “Failure: Why Science Is So Successful” and professor at Columbia University, brings attention to the virtues of courage and patience when advising young investigators on how to handle failure at the beginning of their career.
With about 100 lines of code, a Morgridge Institute for Research team has unleashed a fast, simple and predictive text-mining tool that may turbo-charge big biomedical pursuits such as drug repurposing and stem cell treatments.
A hard disk drive contains a circular shiny silver disk, similar to a CD or DVD but much smaller. This disk is coated with a magnetic material, and information is stored by magnetizing very tiny pieces of this surface.
The mystery of what controls the range of developmental clocks in mammals — from 22 months for an elephant to 12 days for a opossum — may lie in the strict time-keeping of pluripotent stem cells for each unique species.
Darryl Thelen, professor in mechanical engineering and biomedical engineering at the University of Wisconsin-Madison, conducts research with this notion in mind while using computational models of the musculoskeletal system and high-throughput computing resources to refine knee surgical procedures.
Hannah Carey, a UW-Madison professor of comparative biosciences, uses hibernating mammals as models to study extreme changes in physiology and nutrition that occur on a seasonal basis. Carey discusses this remarkable process and its potential to impact human health by improving trauma care.
A concussion is defined as a traumatic blow to the head coupled with some kind of altered consciousness. Some people refer to it as seeing stars, getting your bell rung. People may feel disoriented for a period of time.
A broad definition says virtual reality is the idea of combining the physical world and the artificial world in such a way that the two are indistinguishable. How could technology provide all of the sensory sensations or different ways that people see, feel and hear the world such that the artificial and physical are blended together?
The tides are the result of the moon exerting its gravitational force on the ocean and bulging it both toward and away from the moon. The tide is higher, the ocean is higher, at the location closest to the moon and on the opposite side of the Earth.
Infectious agents—both bacterial and viral—are responsible for about 25 percent of all human cancers. The virus infection does not by itself cause cancer, but can interfere with a cell’s normal maintenance of things.
It’s a complicated question because, while researchers have grown spruce seedlings on the International Space Station, they haven’t grown full-size trees. Using knowledge of how trees operate on Earth, scientists can guess what’s going to happen when they’re grown in space.
Swallowing is one of the most obvious functions the epiglottis serves, because it hoods over the airway, or larynx, when you eat and drink. When you swallow, the muscles in your throat respond by pulling the voice box up and underneath the tongue, and the epiglottis is pulled to cover over the larynx.
Not all mosquitos can transmit the Zika virus, and that’s the case with any mosquito-borne pathogen. There are about 3,000 species of mosquitos in the world and only a handful—about 150—are considered vectors of pathogens, capable of spreading viruses.
In a guest blog for the Nov. 22 online edition of Scientific American, Morgridge Institute CEO Brad Schwartz writes about a challenge research institutions face in conveying the true societal value of research.
OnLume received the $300,000 Phase I SBIR grant through the National Cancer Institute (NCI) at the National Institutes of Health (NIH) for the development of imaging and lighting systems for transient lighting in fluorescence image-guided surgery.
The prospect of creating artery “banks” available for cardiovascular surgery, bypassing the need to harvest vessels from the patient, could transform treatment of many common heart and vascular ailments.
3D printing involves making an object layer by layer. There are many 3D printing techniques, and they all differ in how each layer is constructed. Each type of printer has a different opportunity or mechanism for adding color.
A solar flare is a release of magnetic energy from the sun. The energy is stored as a magnetic field around the sun, and then it is released with energetic particles and waves coming from the solar surface.
In order to understand the biochemical underpinnings of disease, it is imperative to shrink down to the molecular level. It’s this mentality that steered Mateusz Manicki all the way from Poland’s Gdansk University to Madison, Wisconsin to study mitochondrial proteins. Manicki will be using mass spectrometry resources to better understand the functionality of cells contributing to a given disease.
Wisconsin biotechnology advocacy organization BioForward honored two giants in state biomedical innovation — stem cell research pioneer James Thomson and entrepreneur Ralph Kauten — for their scientific and business achievement during its annual summit September 27 in Madison.
Wisdom teeth are the third set of permanent molars that typically come in between the ages of 17 and 25. Some people don’t form them anymore, and a lot of people that do need to have wisdom teeth taken out.
Newmark, who joined the Regenerative Biology research focus at the Morgridge Institute and the Department of Zoology this summer, is also serving as the first recipient of the Burnell R. Roberts Chair in Regenerative Biology.
The formation of the northern and southern lights—known as aurora borealis and aurora australis—begins with solar flares from the sun. The solar flares eject groups of electrons from the sun that act as a wind and flow toward the Earth.
In the amphibian world, the axolotl is the replacement-parts king. This endangered Mexican salamander serves as its own NAPA store for lost body parts, able to fully regenerate limbs, tail, heart, spine and eyes — making it a model of curiosity for regenerative biologists.
Whether an object floats or sinks in water is determined by the ratio of its weight compared to its volume. If an object of a certain volume weighs more than an equal volume of water, it sinks because the water can’t hold it up. If an object weighs less than an equal volume of water, it floats because the water can support its weight.
The Laboratory of Biomolecular Mass Spectrometry (LBMS), launched in summer 2015, accelerates the university’s ability to apply this powerful technology to high-impact projects, says Joshua Coon, UW-Madison professor of chemistry and biomolecular chemistry and LBMS director.
Christopher Taylor has the hands of a musician, his fingers most at home striking the keys of a piano, and an analytical mind honed by years of computer programming. Now after tackling his latest endeavor, Taylor can also call himself an engineer, a builder, a maker.
Cancer is, essentially, cells that have started to grow uncontrollably and stop behaving like normal cells. Viruses are an attractive treatment tool because they, by their very nature, are manipulators of cells. It may be possible to reengineer viruses in a way that could either stop cancers from growing or kill cancer cells.
Durant is director of the Massachusetts Institute of Technology (MIT) Museum, where he began in 2005 after decades of leadership at major British science museums. This summer, Durant joined the scientific advisory board of the Morgridge Institute for Research, where he will give guidance to an outreach program that attracts more than 30,000 people annually to the Discovery Building.
Can we fight cancer by targeting its metabolism, essentially starving tumors of the nutrients they need to survive? It’s one of the intriguing big-picture questions in the research field of Jing Fan, a new investigator in the Morgridge Institute for Research metabolism theme.
Most earthquakes occur when a geological fault, fractures within the earth’s crust, slip and release energy. Individual faults, some of which form the tectonic plate boundaries, build up strain over decades and centuries to eventually break in large earthquakes.
Since chick embryos lack a developed immune system, scientists are able to engraft other types of cells — including mouse and human cells — into the friendly 3D confines of the embryo and study their behavior. Under the right conditions, the introduced cells can thrive.
Stem cells are special cells inside your body that can multiply indefinitely, or make copies of themselves. They can also differentiate, meaning they can become every cell type that’s present in your body.
Phillip Bourne, who since 2014 has served as the NIH’s first associate director for data science, will give the keynote address June 30 at the annual research retreat for Wisconsin’s own big-data center, called the Center for Predictive Computational Phenotyping (CPCP).
It’s a great guess, but an octopus is not a mammal. An octopus is an invertebrate animal, which means it has no spine. More specifically, an octopus is a cephalopod, like squid and cuttlefish. They’re some of the smartest invertebrates.
The Morgridge Institute for Research will be well represented in this year’s statewide Governor’s Business Plan Contest, with three of the 13 finalists having direct ties to the Morgridge Medical Engineering research group.
When it comes to dinosaur extinction, the working idea is what’s called the bolide impact. This is the hypothesis that a meteorite came to the surface of the Earth, hit the Earth, and led to the extinction of the dinosaurs.
Phil Newmark, a developmental biologist studying the mysteries of how the body regenerates damaged tissue, will join the Morgridge Institute for Research and the University of Wisconsin-Madison Department of Zoology
It’s not every day someone gets the chance to stroll through the East Wing of the White House, snapping photos and checking out its famous Blue Room and Red Room. Dave Pagliarini experienced that and more during his trip to the nation’s capital May 5-6 to receive his Presidential Early Career (PECASE) award.
In a time when million-dollar security breaches of household name corporations regularly make headlines and complicate lives, computer science undergraduates at America’s universities remain surprisingly underexposed to basic cybersecurity tactics.
When it comes to diagnosing breast cancer and predicting how the disease will progress in a patient, current practice is seeing a gap between the imaging information scientists can get from a high resolution microscope and the lower resolution images typically gathered in the clinical setting.
We need supercomputers because scientists are doing really awesome work that requires lots of computing time. For some of this work, if we weren’t using supercomputing to break up tasks and make processing faster, it would take years or decades to complete.
The Kopietz Family (L-R): Lucas, Courtni, Jeff, Teresa, and Tyler. Courtni and her dad Jeff are soon embarking on a 100-plus mile trek across Portugal to celebrate Courtni’s 19th year cancer-free. All proceeds donated to #100miles4research campaign will benefit the Morgridge Institute for Research.
Electricity is a complex topic that drives the world as we know it today, from Thomas Edison’s iconic light bulb to the satellites that enable our cell phones. Fundamentally, electricity is just the presence and flow of electric charge.
Jan Huisken, a scientist who develops tools to image biology in its unaltered natural state, will lead the medical engineering focus area at the Morgridge Institute for Research and help catalyze a campus-wide multi-scale imaging initiative.
A few years ago, a global team of scientists parlayed decades of research into the discovery of the Higgs boson, a subatomic particle considered a building block of the universe. A humble software program called HTCondor churned away in the background, helping analyze data gathered from billions of particle collisions.
Dave Pagliarini, Director of Metabolism at the Morgridge Institute for Research and Associate Professor of Biochemistry at the University of Wisconsin-Madison, has received the U.S. government’s highest honor for scientists in the early stages of their careers.
Skala’s research problems focus on cancer detection and treatment, and her expertise in light-based, optical imaging is giving clinicians revolutionary new tools for the fight. Skala will be bringing her talents this summer from Vanderbilt University to the Morgridge Institute for Research and the University of Wisconsin-Madison, as a Morgridge investigator and professor of Biomedical Engineering (BME).
The Yahara watershed is a geographic area in south central Wisconsin. It is comprised of about 370,000 people and 359 square miles home to the city of Madison, the University of Wisconsin-Madison, and this chain of lakes we refer to as the Yahara lakes.
The Morgridge Institute for Research, as part of its Metabolism Initiative, is working with a University of Wisconsin-Madison team to greatly expand the scope of “mass spec” applications on campus. A new resource housed in the UW-Madison Biotechnology Center brings together a multi-million dollar investment in mass spectrometry tools from multiple sources to form a central repository to tackle large-scale investigations.
There are more than 3,400 species of snakes worldwide, and they exist on every continent except Antarctica. We have about 50 snake species in the United States and 21 different snake species in the state of Wisconsin.
We really don’t know if space goes on forever. The universe is big enough that we can’t see all of it for a number of reasons. And there are ways that we could live in a space that doesn’t go on forever, but still has no actual edge to it.
Sounds reach our ears from different locations and first travel through the ear into the ear canal. Then tiny bones inside the middle ear end up vibrating and pushing on a small window. This then gets a special membrane inside our ear to vibrate.
The first step in forming a memory is called encoding, and encoding starts with perception. If you remember back to the first time you met your best friend, you encoded or perceived a lot of information about them.
In high school you learn that matter is made of atoms, atoms are made of electrons and nuclei, and nuclei contain neutrons and protons. That’s a basic picture of matter, but it’s an incomplete one. Missing in that picture is a full particle called neutrinos.
Machine learning is an area of computer science that focuses on building computer programs that help machines learn by example. This is similar to the way young children learn about the world around them.
Dietram Scheufele, professor of life sciences communication at UW-Madison and Morgridge Institute for Research affiliate, will serve on a national panel examining the implications of human genome editing.
Researchers from the Morgridge Institute for Research and the Murdoch Children’s Research Institute (MCRI) in Australia have devised a way to dramatically cut the time involved in reprogramming and genetically correcting stem cells, an important step to making future therapies possible.
The word “crystal” comes from the Greek “krystallos,” meaning clear ice. A crystal is defined as a solid material consisting of a three-dimensional periodic ordering of atoms, molecules or ions. Crystals form by a process called crystallization that signifies a transition from chaos to perfection.
Afterschool Expeditions, a program in which elementary and middle school students engage in structured, hands-on science activities at the Discovery Building, has become an integral part of the outreach programming produced by WARF and the Morgridge Institute for Research in partnership with Science Alliance and numerous UW-Madison groups.
When we try to identify different species in nature today, we usually think of that question in terms of interbreeding. We look at different populations, whether they look different or the same, and ask, do they ever interbreed with each other or encounter each other in nature?
Gene editing involves changing the sequence of letters in the DNA. Researchers like to edit genes so they can understand the function of them, particularly genes that relate to various types of disorders that physicians have seen in the clinic. We can use this information to generate new hypotheses of how genes influence diseases.
In August 2015, just before going on vacation, virology researcher Dave O’Connor teed up the largest data analysis challenge of his lifetime. The computing run included 694 independent jobs, each one with about one billion points of genomic data to process. O’Connor returned to find that his “set it and forget it” gamble paid off handsomely: 693 of the 694 computing runs had fully completed, with zero human intervention.
The Morgridge Institute’s medical engineering team brought UW-Madison clinicians to the Advanced Fabrication Laboratory, or “Fab Lab,” Oct. 1 to celebrate the launch of the BerbeeWalsh Prototype Pathway.
A new system developed by scientists at the Morgridge Institute for Research and the University of Wisconsin-Madison may provide a faster, cheaper and more biologically relevant way to screen drugs and chemicals that could harm the developing brain.
Some volcanoes, like the Cascade Volcanoes up in Washington and Oregon, are of the type called stratovolcano. These steep volcanoes sometimes erupt explosively, and other times have calmer lava flows that just spill out on the surface. The material from eruptions, like lava and ash, build up and cause these volcanoes to have a character like a layer cake.
Pilar Ossorio, the Morgridge Institute for Research bioethicist in residence, will serve on an international committee convened by the National Academies of Science (NAS) to address the ethically challenging frontiers of human gene editing technology.
The announcement today of $250 million being raised for the University of Wisconsin-Madison through the John and Tashia Morgridge Match program is truly inspirational. At a pivotal time for the university, this effort supports a critical mass of new endowed professorships that will help attract and retain the very best talent to Wisconsin.
Plants can propagate in two ways: sexually and asexually. Sexual propagation is through seeds. Seeds develop from the sexual organs of flowers. But some plants take a very long time to be able to propagate by seeds.
Dave Pagliarini, UW-Madison associate professor of biochemistry, has been selected to lead the Morgridge Institute Metabolism Initiative, which will provide leadership, infrastructure and community building to this growing UW-Madison research area. Pagliarini, an expert on mitochondria structure and function, reflects on some of the opportunities ahead.
Dave Pagliarini, a University of Wisconsin-Madison associate professor whose departmental home put metabolism research on the map worldwide, will help define the future of Wisconsin metabolism science as a lead investigator at the Morgridge Institute for Research.
Directionally you never know where a balloon is going to go because the wind controls it, I don’t. I can send a balloon higher or lower, but not steer it in specific directions. So before we send passengers up in a hot air balloon, we send up a small hydrogen balloon that tells us the wind speed and direction.
The genes that turn on and off in precisely timed patterns, known as oscillatory genes, play an essential role in development functions like cell division, circadian rhythms and limb formation. But without a time-lapse view of genetic expression, these genes have gone largely undiscovered.
Eric Ronning, a recent UW-Madison graduate and member of Morgridge Institute’s medical engineering team, also appreciates the importance of fostering a cohesive, talented team for collaborative innovation.
Imagine this: Stick your hand out of the window of a car that travels at around 60 mph, and you will notice how lift is being produced as you twist your hand up and down. As the car accelerates, you will notice that no matter how you shape your hand, lift is always being produced.
It’s widely believed that the Moon features networks of caves created when violent lava flows tore under the surface from ancient volcanoes. Some craters may actually be “skylights” where cave ceilings have crumbled.
For decades, scientists and physicians have believed that the appendix really doesn’t have a function in human beings. It may have had a purpose in some living thing tens of thousands of years ago, but that purpose never persisted in humans.
The Kuiper belt, named after astronomer Gerard Kuiper, is a massive, icy region of our solar system that exists just beyond the planets. Actually shaped more like a donut than a flat belt, the Kuiper belt is best known as home of the dwarf planet Pluto.
The Wisconsin Alumni Research Foundation (WARF) Accelerator Program helps discoveries patented by WARF move further along the commercialization process by providing funding and connections to a network of industry experts.
The Software Assurance Marketplace (SWAMP) has added three new services to its suite of assurance offerings, including support for software written in Ruby, support for Android software written in Java, and access to Parasoft’s Jtest and C/C++test static analysis tools.
What we use to purify water depends a lot on where the water’s coming from and what we want to do with it. If we’re going to drink water it needs to be very clean and very safe. There are lots of regulations that we have to meet.
The International Astronomical Union decided that full-sized planets must orbit the sun, have a round shape, and have cleared their orbits of other objects. Pluto fulfills the first two criteria, but not the third.
Now in its ninth year, the Rural Summer Science Camp brings teachers and high school students from rural Wisconsin communities to Madison to learn about advances in stem cell science and careers in research. A large emphasis is placed on hands-on, experiential learning. Campers aren’t just hearing about science– they’re doing science.
An autopilot is a flight control system that allows a pilot to fly an airplane without continuous hands-on control of the airplane. It allows the pilot to focus on higher-order tasks such as navigating, communicating with air traffic control, planning for weather contingencies and rerouting associated with any kind of emergency circumstance.
Without a big advance in early diagnosis and treatment, experts forecast as many as 14 million new Alzheimer’s cases by 2050 occurring among the 78 million baby boomers, the first wave of whom just turned 65.
With metabolic pathways now seen as essential players in human development and aging, as well as common diseases such as cancer, diabetes and Alzheimer’s, metabolism has become a wellspring of new knowledge for biologists.
Scientists know that the hormone estrogen is a major driver in the growth of cervical cancer, but a new study examining genetic profiles of 128 clinical cases reached a surprising conclusion: Estrogen receptors all but vanish in cervical cancer tumors.
The UW-Madison campus community has high expectations for the campus-wide Metabolism Initiative, which is spearheaded by the Morgridge Institute for Research and is in the process of a national search for a leader.
Gravity is this invisible force that pulls objects toward one another. And one of the things that gravity does is pull us toward the earth. So it’s important to know that’s what gravity is. And then center of gravity is sort of this middle point where all of a body’s weight or an object’s weight is.
Cancer occurs when one of the tissues in our body decides to grow uncontrollably, and our immune system is not able to recognize and destroy it. So the tissue continues to grow and can eventually break off into pieces and attach to other parts of the body and affect our health.
Beginning Monday, May 4, the Morgridge Institute has launched a partnership with the Wisconsin State Journal called “Blue Sky Science,” which will feature weekly video Q&As from Discovery Outreach participants on cool science topics.
3-D printing refers to a kind of manufacturing where a part is built up layer by layer. With a typical machine, you take a block of material and subtract away. With additive manufacturing, or 3-D printing, you start with nothing and you add layer by layer until you have a final part.
The tools of modern biology have made it possible to obtain an incredibly detailed picture of how cancer cells differ from healthy cells at the molecular level. Somewhat paradoxically, despite these meticulous portraits of cancer, it remains remarkably difficult to answer the very fundamental question: What caused cancer in this patient?
Time and again the Madison community has shown itself to be an incubator for collaborative ideas and innovative work. Adam Uselmann, a research associate at the Morgridge Institute for Research, has seen some of his collaborations grow into a new postdoctoral opportunity.
Interestingly, in the course of the day, your heart will beat somewhere around 100,000 times and over a calendar year might beat up to 35 million times. Over the course of a lifetime then, your brain and your heart have to work together to engineer 3 billion heartbeats.
Katie Vermillion’s research into the mysterious work of the neural crest — a mobile, multitasking marvel of early embryonic development — begins simply enough every Monday morning with a delivery of five-dozen chicken eggs from a local farmer.
Ellen Arena’s young career has already taken her from an undergraduate degree at UW-Parkside in Racine to advanced degrees in British Columbia and Paris. Her research also has traversed from molecular biology to bacterial pathogens to microscopy and computation.
It can be difficult to define the threshold for when data becomes “big data,” but it is clear that as research technologies become more sophisticated, scientists are collecting and analyzing information that necessitates advanced computing tools.
From a philanthropic standpoint, extraordinary patience is required of individuals who believe strongly enough in the possible outcomes to provide ongoing support. Mildred “Babe” and Marv Conney are among those whose faith in the potential miracles of science has remained unshaken for nearly 30 years.
As an exercise in the high-stakes world of software security, Patrick Beyer ran an open-source medical technology software package through the Software Assurance Marketplace (SWAMP) to see what would happen.
Omid Forouzan, as part of the new Morgridge Fellowship program, wants to harness engineering and biomedical fields to develop a microfluidic multi-cell culture model. This microscale research tool will allow for study of cell-cell interactions in the development of HPV-associated cervical cancer.
When Edgar Spalding crunches data on Wisconsin corn, the numbers boggle the mind: Four million acres are planted annually, with 30,000 seeds planted per acre, producing about 120 billion seedlings sprouting skyward each May.
Andreas Velten, a Morgridge Institute Affiliate with the Medical Engineering Group and assistant scientist with UW-Madison Laboratory of Optical and Computational Instrumentation, won a grant for his work in imaging technology through the Air Force’s Young Investigator Research Program (YIP).
The outdated hardware underlying computed tomography (CT) scanners has created a bottleneck for improving its imaging potential. An innovative project out of the Medical Engineering group at the Morgridge Institute for Research seeks to bypass this obstacle with a design for a multi-source x-ray tube.
In recent decades, a few genetic strains of mice have proven invaluable to medical researchers in serving as “surrogates” capable of supporting the growth of human cells. These “xenografted mouse models” can give scientists a relevant window into human biology that may point to new therapies and understanding of disease — or at the very least, validate or disprove results from a laboratory dish.
What do you do after launching a computer networking company in the gung-ho 1990s, growing it to 700-plus employees across the Midwest, serving some of the world’s largest technology companies, then selling the company 13 years later?
During his leadership Dahlberg focused on three core goals. They included redefining the institute’s mission, improving financial accountability across the institute, and hiring a dynamic permanent director who could implement a long-term vision.
Thomas “Rock” Mackie is no stranger to the practice of innovation and entrepreneurship. From the research and development stage to commercialization and investments, Mackie has seen ideas become tangible, marketable products on more than one occasion.
The Software Assurance Marketplace (SWAMP) was awarded the ISE® North America Project of the Year in the Academic/Public Sector Category. The SWAMP offers a high-performance computing platform that analyzes software for weaknesses with an array of open source and commercial software security testing tools.
As CEO of the Morgridge Institute for Research, I am reminded every time I enter our building of the extraordinary vision, commitment and generosity of John and Tashia Morgridge. The entire University of Wisconsin community received another wonderful reminder last week, with the announcement $100 million lead gift that represents a brilliant investment in the heart of a great university.
Drs. Brad Schwartz, CEO of the Morgridge Institute for Research; Terri Young, Chair of the Department of Ophthalmology and Visual Sciences (DOVS); and David Gamm, Director of the McPherson Eye Research Institute (MERI); are pleased to announce the recipient of the $25,000 grant award for Metabolism Research in Age-Related Macular Degeneration. This pilot award is funded by the Morgridge Institute and the James Christenson Estate Macular Degeneration Research Fund.
SHINE Medical Technologies, a medical isotope company developing technology that originated from University of Wisconsin-Madison research, has signed a $125 million term sheet that represents a massive step in bringing an important medical advance to market.
Bill Swisher, the assistant vice president for corporate and institutional partnerships at Carnegie Mellon University (CMU), has been named the new chief development officer of the Morgridge Institute for Research.
Two University of Wisconsin-Madison teams are among only seven undergraduate finalists for the 2014 National Collegiate Inventors Competition, which honors the latest in student creativity and innovation.
In the growing movement for urban agriculture, microgreens are becoming a popular, profitable option for producers. Tasty and nutritious, microgreens can be grown inside any time of year, mature from seed to harvest in 10-14 days, and sell at $20-30 per pound.
A multidisciplinary team at the University of Wisconsin-Madison and the Morgridge Institute for Research is creating a faster, more affordable way to screen for neural toxins, helping flag chemicals that may harm human development.
Thousands of visitors young and old will have the chance to indulge their “inner scientist” during the 2014 Wisconsin Science Festival, held this year from Oct. 16-19, with more than 20 communities statewide joining Madison in the party.
Unlike many of us, Andreas Velten loves working in windowless rooms. His research tools are shrouded in sealed black boxes to keep out unwanted light. He’s been known to cover red building exit signs to extinguish any trace of visual noise.
Using an imaging technique that illuminates viral behavior within live cells, a team of scientists at the University of Wisconsin-Madison and the Morgridge Institute for Research are identifying new targets to derail the disease-spreading machinery of human immunodeficiency virus (HIV).
Much of biostatistics involves finding and mapping the predictable pathways that can tell us something about what makes a disease tick. But Anthony Gitter finds equal importance in the statistical back roads that other scientists might ignore.
Scientific imaging has long been a research strength at the University of Wisconsin-Madison, home of major advances in cellular-scale optical imaging, human-scale medical imaging and many spaces in between.
The projects looked right at home in the Discovery Town Center: A row of four colorful scientific posters describing the status of stem cell therapies, complete with microscopic images, graphics, flow charts and detailed reference lists.
The Board of Trustees of the Morgridge Institute for Research has approved a new Morgridge focus area in metabolism, a growing research field with enormous potential to treat or reverse a broad spectrum of human diseases.
Writing today (July 14, 2014) in the journal Nature Communications, a group led by University of Wisconsin-Madison stem cell researcher Igor Slukvin reports the discovery of two genetic programs responsible for taking blank-slate stem cells and turning them into both red and the array of white cells that make up human blood.
Secure Decisions, a leading provider of assessment tools to enhance software security, is partnering with the Software Assurance Marketplace (SWAMP) to build a powerful and publicly accessible resource to improve the software that drives everyday life.
Infectious diseases have large-scale human impact, and virology research works to tackle current issues while building knowledge to prepare for future threats and to provide more broad spectrum controls. John and Jeanne Rowe have provided long-term support for Ahlquist’s research group, which studies viruses like HIV, human papillomavirus and Chikungunya.
Thomson’s discoveries in human stem cell research at UW-Madison have redefined biomedicine, first with the isolation and culturing of human embryonic stem cells in 1998; then in the development of human pluripotent stem cells from adult skin cells in 2007.
This is an important and exciting time to be studying virology, Ahlquist says, thanks to the new perspective provided by genomics and advanced computation. Prior to this time, incremental advances in knowledge often lacked the larger context, how these puzzle pieces all fit together.
The human genome contains our most personal and sensitive information—the complete compendium of our inherited traits. Even the smallest samples of human tissue and accompanying health histories provide vast troves of data to the biomedical community, which in turn has a legal and ethical obligation to safeguard its usage.
Asked why he became a biochemist, Jim Dahlberg reflected briefly and answered, “I always found science exciting, interesting, and relatively easy. I just thought that it would be the most rewarding way to spend my life. And once I was introduced to the world of biochemistry I was hooked.”
While growing up in Canada, Thomas Rockwell (Rock) Mackie, director of Medical Engineering, had three heroes: Albert Einstein, Enrico Fermi, and antarctic explorer Ernest Shackelton. They inspired a fascination with nuclear physics and scientific expedition that Mackie has pursued in both academia and industry.
Thomas “Rock” Mackie, director of medical engineering at the Morgridge Institute for Research, will receive the highest honor in the field of medical physics for his game-changing contributions to medical imaging.
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