Archives

Area: Metabolism

Jason Cantor

Our lab has broad interests in modeling, understanding, and exploiting the impact of environmental factors on human cell metabolism, with a particular focus on hematological cancers and normal lymphocytes. We use an interdisciplinary approach to discover unforeseen biological (and pharmacological) phenomena in cell metabolism, cancer biology, and immunology that may have been overlooked or misinterpreted […]

John Denu

The Denu lab is currently focused on understanding the molecular links between metabolism and epigenetic pathways in human health and age-associated diseases. Linking metabolism with the epigenome Chromatin remodeling enzymes rely on co-enzymes derived from metabolic pathways, suggesting coordination between nuclear events and metabolic networks. Investigations are underway to understand the link between metabolism and […]

Rick Eisenstein

Our research is aimed at elucidating the mechanisms by which mammalian iron homeostasis is maintained in response to specific physiological and pathological situations. Iron is crucial to cell viability because it is a component of proteins that function in a number of physiological processes including respiration and cell division. However, excess iron can be toxic […]

Josh Coon

The mission of Coon Laboratories is to facilitate expedient, comprehensive systems analysis at the molecular level to advance biomedical, biofuel, and biochemical research. The sequencing of the human genome marked the beginning of a collective scientific expedition to understand complex organisms. Genes, of course, merely contain the instructions for which proteins will populate the cell. […]

Rachel Guerra

I am a postdoc in the Pagliarini lab. I graduated from the Walensky lab at Harvard University, where I applied chemical probes, called stapled peptides, as prototype therapeutics to reactivate the deregulated apoptotic signaling pathway in cancer. I am interested in elucidating the biochemical function of uncharacterized mitochondrial proteins. Education Ph.D. Biological Chemistry and Molecular […]