Thermogenesis by the Futile Creatine Cycle: quantitative contribution and activation mechanism”
Dr. Lawrence Kazak, PhD, Canada Research Chair in Adipocyte Biology, Assistant Professor, Rosalind & Morris Goodman Cancer Institute, Department of Biochemistry, McGill University
Our research is focused on the molecular underpinnings controlling energy dissipation by adipocytes. In recent years, we have focused our attention on a UCP1-independent pathway called the futile creatine cycle. Along with identifying the effector proteins of the futile creatine cycle, and their transcriptional regulation in vivo, we have generated genetic mouse models to explore the quantitative contribution of the futile creatine cycle to thermogenesis and used structural and biochemical methods to elucidate its activation mechanism.
Host: Andrea Galmozzi
The colloquium will feature invited lecturers and bring together metabolism researchers to share ideas, expertise and resources. Visiting lecturers will first present a seminar on their work (time and dates will vary). A more informal open chalk-talk and discussion, including refreshments, will follow soon after the seminar.