The Rienstra group has pioneered solid-state NMR methods and technologies that matured the discipline to solve high-resolution structures of small proteins. We have also contributed innovative approaches to enable larger structures of assemblies, fibrils and membrane proteins to be addressed and have extended these technologies to increasingly significant biomedical problems. These results are having a major impact on understanding Parkinson’s disease, fungicidal drug action and protein-lipid interactions in blood coagulation.