Studying the chemistry of life and its disruption in human disease.


Update on the Metabolism Theme

The Morgridge Institute is actively searching for a new leader of its Metabolism Theme. The first theme leader, David Pagliarini, has moved on to a position with Washington University in St. Louis. The theme’s interim lead investigator is Melissa Skala, a Morgridge medical engineering investigator and professor of biomedical engineering at UW–Madison.

Launched in 2016, the Morgridge Metabolism Theme has already made a great impact on UW–Madison and beyond. We are serving as a collaborative hub for more than 500 metabolism scientists on campus.

Our established programs are continuing, including:

We look forward to continuing to build on the momentum already established within the metabolism community here in Madison.

Metabolism is the set of life-giving biochemical reactions that enable our cells to grow, develop, and achieve physiological homeostasis. Recent discoveries have revealed that disrupted metabolism underlies a broad swath of both rare and prominent human diseases. In collaboration with UW–Madison via the broader Morgridge Metabolism Initiative, Investigators in the Morgridge Metabolism theme are dedicated to elucidating the basic molecular and genetic aspects of metabolism toward improving metabolic health.

Often called the “chemistry of life,” metabolism provides the fuel for all cellular activities and goes awry in most human diseases.

Jing Fan’s laboratory works towards a quantitative understanding of mammalian cellular metabolism, with a particular focus in cancer metabolism. The lab uses a combination of approaches to investigate how cellular metabolism is rewired to support the spread and growth of cancer, and look at how cellular metabolism is dynamically regulated in response to various microenvironments.

Jason Cantor’s lab has broad interests in modeling, understanding, and exploiting the impact of environmental factors on human cell metabolism, with a particular focus on hematological cancers and normal lymphocytes.

Melissa Skala’s lab develops optical imaging tools to monitor metabolism at the single cell level. These tools are used in living cells, animal models, and patient samples to improve cancer treatment

The Josh Coon Lab facilitates expedient, comprehensive systems analysis at the molecular level to advance biomedical, biofuel, and biochemical research.

Melissa Skala

Jason Cantor

Jing Fan

Josh Coon