Daniela Drummond-Barbosa

Daniela Drummond-Barbosa

Investigator, Regenerative Biology



(608) 262-0060


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Research website

Stem cells maintain the function of many of organs and are also highly influenced by metabolism and physiology. My lab focuses on identifying the metabolic and physiological mechanisms that link the behavior of stem cells and their descendants to diet, stress, and other systemic inputs. To investigate these broadly relevant questions, we take advantage of a powerful genetic model organism, the fruit fly. Fruit flies have well characterized and readily identifiable stem cells, fascinating and complex physiology, and highly evolutionarily conserved biological processes. Our research generates fundamental knowledge about the integration between metabolism and physiology in the control of stem cell lineages in vivo, with potential insights into how deregulation of these processes is tied to stem cell-related diseases.


B.S. in Biochemistry and Immunology, 1991, Universidade Federal de Minas Gerais, Brazil
M.Phil. in Genetics, 1993, Yale University
Ph.D. in Genetics, 1995, Yale University


  • Association for the Advancement of Science Electorate Nominating Committee member, 2020-2023      
  • Shikani/El Hibri Prize for Discovery & Innovation, Johns Hopkins University, 2017
  • Association for the Advancement of Science Fellow, 2014
  • National Research Service Award, National Institutes of Health, 1997-2000
  • Chancellor’s Award for Research, Vanderbilt University, 2006
  • Miles Scholar Award, Bayer Corporation, 1993-1995
  • First place in Biological Sciences college entrance exam, Universidade Federal de Minas Gerais, Brazil, 1988

Selected Publications

  • Gandara, A. C. P., Drummond-Barbosa, D. Warm and cold temperatures have distinct germline stem cell lineage effects during Drosophila oogenesis. Development 149, dev200149, 2022.
  • Weaver, L. N., Drummond-Barbosa, D. Hormone receptor 4 is required in muscles and distinct ovarian cell types to regulate specific steps of Drosophila oogenesis. Development 148, dev198663, 2021.
  • Matsuoka, S., Armstrong, A. R., Sampson, L. L., Laws, K. M., Drummond-Barbosa, D. Adipocyte metabolic pathways reprogrammed by diet control the female germline stem cell lineage in Drosophila melanogaster. Genetics 206:953-971, 2017.
  • Laws, K., Drummond-Barbosa, D. AMP-activated protein kinase has diet-dependent and –independent roles in Drosophila oogenesis. Dev. Biol. 420:90-99, 2016.
  • Armstrong, A. R., Laws, K., Drummond-Barbosa, D. Adipocyte amino acid sensing controls adult germline stem cell number via the amino acid response pathway and independently of Target of Rapamycin signaling in Drosophila. Development 141:4479-4488, 2014.
  • Ables, E. T., Drummond-Barbosa, D. A steroid hormone functions with chromatin remodeling factors to control germline stem cells in Drosophila. Cell Stem Cell 7:581-592, 2010.
  • LaFever, L., Feoktistov, A., Hsu, H.-J., Drummond-Barbosa, D. Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary. Development 137:2117-2126, 2010.
  • Hsu, H.-J., Drummond-Barbosa, D. Insulin levels control female germline stem cell maintenance via the niche in Drosophila. Proc. Natl Acad. Sci. USA 106(4), 1117-1121, 2009.
  • LaFever, L., Drummond-Barbosa, D. Direct control of stem cell division and germ line development by neural insulin in Drosophila. Science 309(5737), 1071-1073, 2005. Drummond-Barbosa, D., Spradling, A. C. Stem cells and their progeny respond to nutritional changes during Drosophila oogenesis. Dev. Biol., 231(1), 265-78, 2001.