wildtype mosaic ovariole
Regenerative Biology

Drummond-Barbosa Lab

We investigate the metabolic and physiological mechanisms that link the behavior of stem cells and their descendants to diet, stress, and other systemic inputs using Drosophila melanogaster oogenesis as a model system.

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Tissue stem cell lineages sense and respond to the external and systemic environments. Our lab investigates the physiological, cellular and molecular in vivo mechanisms involved in this complex process using the powerful Drosophila oogenesis model. Over the past 20 years, we have made major discoveries shedding light on a multi-organ network that tightly coordinates the germline stem cell lineage with whole-body physiology and diet. Learn more about our research >

Principal Investigator Daniela Drummond-Barbosa

Stem cells maintain the function of many of organs and are also highly influenced by metabolism and physiology. My lab focuses on identifying the metabolic and physiological mechanisms that link the behavior of stem cells and their descendants to diet, stress, and other systemic inputs. To investigate these broadly relevant questions, we take advantage of a powerful genetic model organism, the fruit fly. Fruit flies have well characterized and readily identifiable stem cells, fascinating and complex physiology, and highly evolutionarily conserved biological processes. Our research generates fundamental knowledge about the integration between metabolism and physiology in the control of stem cell lineages in vivo, with potential insights into how deregulation of these processes is tied to stem cell-related diseases.

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