Mark Horswill

Mark Horswill

Senior Research Specialist

Area:

Phone:

(608) 520-8682

Email:

[javascript protected email address]

I study positive-strand RNA virus RNA replication mechanisms and virus-cancer associations.

Education

B.S. Biological Sciences, 1997, University of Wisconsin-Parkside

M.S. Applied Molecular Biology, 1999, University of Wisconsin-Parkside

Honors and Awards

3rd Mayo Clinic Angiogenesis Symposium Young Investigator Award for poster abstract “Structure and Functional Analysis of Snrk-1 in Vascular Development” October 2008

Selected Publications

  • Unchwaniwala, H. Zhan, J. Pennington, M. Horswill, J. A. den Boon, and P. Ahlquist. Subdomain Cryo-EM Structure of Nodaviral Replication Protein A Crown Complex Provides Mechanistic Insights into RNA Genome Replication. Proc Natl Acad Sci U S A. 2020, Jul 20;202006165.doi: 10.1073/pnas.2006165117. Epub 2020 Jul 20. PubMed PMID: 32690711
  • E. Spurgeon, J. A. den Boon, M. Horswill, S. Barthakur, O. Forouzan, J. S. Rader, D. J. Beebe, A. Roopra, P. Ahlquist, and P. F. Lambert. Human Papillomavirus Oncogenes Reprogram the Cervical Cancer Microenvironment Independently of and Synergistically with Estrogen. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9076-E9085. doi: 10.1073/pnas.1712018114. Epub 2017 Oct 9. PubMed PMID: 29073104.
  • J. Ertel, D. Benefield, D. Castaño-Diez, J. G. Pennington, M. Horswill, J. A. den Boon, M. S. Otegui, P. Ahlquist. Cryo-Electron Tomography Reveals Novel Features of a Viral RNA Replication Compartment. Elife. 2017 Jun 27;6. pii: e25940. doi: 10.7554/eLife.25940. PubMed PMID: 28653620; PubMed Central PMCID: PMC5515581.
  • Zeng, L. Lu, NT Chan, M Horswill, P. Ahlquist, X. Zhong, W. Xu. Systematic
    identification of Ctr9 regulome in ERα-positive breast cancer. BMC Genomics. 2016
    Nov 9;17(1):902.
  • Bodelon, S. Vinokurova, J. N. Sampson, J. A. den Boon, J. L. Walker, M. A. Horswill, K. Korthauer, M. Schiffman, M. E. Sherman, R. E. Zuna, J. Mitchell, X. Zhang, J. F. Boland, A. K. Chaturvedi, S. T. Dunn, M. A. Newton, P Ahlquist, S. S. Wang, N. Wentzensen. Chromosomal Copy Number Alterations and HPV Integration in Cervical Precancer and Invasive Cancer. Carcinogenesis. 2016 Feb;37(2):188-196. doi: 10.1093/carcin/bgv171. Epub 2015 Dec 9. PubMed PMID: 26660085; PubMed Central PMCID: PMC4834967.
  • A. den Boon, D. Pyeon, S. S. Wang, M. Horswill, M. Schiffman, M. Sherman, R. Zuna, Z. Wang, S. Hewitt, R. Pearson, M. Schott, L. Chung, Q. He, P. F. Lambert, J. Walker, M. A. Newton, N. Wentzensen, and P. Ahlquist. Molecular Transitions from Papillomavirus Infection to Cervical Precancer and Cancer: Role of Stromal Estrogen Receptor Signaling. Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):E3255-64. doi: 10.1073/pnas.1509322112. Epub 2015 Jun 8. PubMed PMID: 26056290; PubMed Central PMCID: PMC4485108.