Publications

2024

• Multiphoton excited polymerized biomimetic models of collagen fiber morphology to study single cell and collective migration dynamics in pancreatic cancer.
  Mancha S, Horan M, Pasachhe O, Keikhosravi A, Eliceiri KW, Matkowskyj KA, Notbohm J, Skala MC, Campagnola PJ.
  Acta Biomater. 2024 Aug 23.
• Metabolic changes in Toxoplasma gondii-infected host cells measured by autofluorescence imaging.
  Gallego-López GM, Contreras Guzman E, Desa DE, Knoll LJ, Skala MC.
  mBio. 2024 Jul 8:e0072724.
• Autofluorescence lifetime flow cytometry with time-correlated single photon counting.
  Samimi K, Pasachhe O, Guzman EC, Riendeau J, Gillette AA, Pham DL, Wiech KJ, Moore DL, Skala MC.
  Cytometry A. 2024 Jun 28.
• Optical redox imaging to screen synthetic hydrogels for stem cell-derived cardiomyocyte differentiation and maturation.
  Desa DE, Amitrano MJ, Murphy WL, Skala MC.
  Biophotonics Discovery. 2024 May 20;1(1):015002.
• Quantifying in vivo collagen reorganization during immunotherapy in murine melanoma with second harmonic generation imaging.
  Heaton AR, Burkard NJ, Sondel PM, Skala MC.
  Biophotonics Discovery. 2024 May 20; 1(1):015004.
• Classification of Neural Stem Cell Activation State In Vitro using Autofluorescence.
  Morrow CS, Gillette AA, Skala MC, Moore DL.
  J Vis Exp. 2024 Apr 12;(206).
• Same People, Different Results: Categorizing Cancer Registry Cases Across the Rural-Urban Continuum.
  Schiefelbein AM, Krebsbach JK, Taylor AK, Haimson AK, Varley PR, Skala MC, Eason JM, LoConte NK.
  WMJ. 2024 May;123(2):78-87.
• Metabolic priming of GD2 TRAC-CAR T cells during manufacturing promotes memory phenotypes while enhancing persistence.
  Cappabianca D, Pham D, Forsberg MH, Bugel M, Tommasi A, Lauer A, Vidugiriene J, Hrdlicka B, McHale A, Sodji QH, Skala MC, Capitini CM, Saha K.
  Mol Ther Methods Clin Dev. 2024 Apr 10;32(2):101249.
• Targeting DNMT3A-mediated oxidative phosphorylation to overcome ibrutinib resistance in mantle cell lymphoma.
  Hoang NM, Liu Y, Bates PD, Heaton AR, Lopez AF, Liu P, Zhu F, Chen R, Kondapelli A, Zhang X, Selberg PE, Ngo VN, Skala MC, Capitini CM, Rui L.
  Cell Rep Med. 2024 Mar 23:101484.
• Autofluorescence is a biomarker of neural stem cell activation state.
  Morrow CS, Tweed K, Farhadova S, Walsh AJ, Lear BP, Roopra A, Risgaard RD, Klosa PC, Arndt ZP, Peterson ER, Chi MM, Harris AG, Skala MC, Moore DL.
  Cell Stem Cell. 2024 Mar 13:S1934-5909(24)00054-7. doi: 10.1016/j.stem.2024.02.011.
• Perspectives on label-free microscopy of heterogeneous and dynamic biological systems.
  Pham DL, Gillette AA, Riendeau J, Wiech K, Guzman EC, Datta R, and Skala MC.
  J. Biomed. Opt. 2024 Feb. 29(S2), S22702

2023

• Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer.
  Ayuso JM, Farooqui M, Virumbrales-Muñoz M, Denecke K, Rehman S, Schmitz R, Guerrero JF, Sanchez-de-Diego C, Campo SA, Maly EM, Forsberg MH, Kerr SC, Striker R, Sherer NM, Harari PM, Capitini CM, Skala MC, Beebe DJ.
  Nat Commun. 2023 Oct 21;14(1):6681.
• Griddient: a microfluidic array to generate reconfigurable gradients on-demand for spatial biology applications.
  Sanchez-de-Diego C, Virumbrales-Muñoz M, Hermes B, Juang TD, Juang DS, Riendeau J, Guzman EC, Reed-McBain CA, Abizanda-Campo S, Patel J, Hess NJ, Skala MC, Beebe DJ, Ayuso JM.
  Commun Biol. 2023 Sep 9;6(1):925.
• Microfluidic device with reconfigurable spatial temporal gradients reveals plastic astrocyte response to stroke and reperfusion.
  Reed-McBain CA, Turaga RV, Zima SRT, Abizanda Campo S, Riendeau J, Contreras Guzman E, Juang TD, Juang DS, Hampton DW, Skala MC, Ayuso JM.
  Lab Chip. 2023 Sep 13;23(18):3945-3960.
• Oxidative phosphorylation inhibitors inhibit proliferation of endometriosis cells.
  Kapur A, Ayuso JM, Rehman S, Kumari S, Felder M, Stenerson Z, Skala MC, Beebe D, Barroilhet L, Patankar MS.
  Reproduction. 2023 May 8;165(6):617-628.
• Development of a multilayer fetal membrane material model calibrated using bulge inflation mechanical tests.
  Fidalgo DS, Samimi K, Oyen ML, Skala MC, Jorge RMN, Parente MPL, Malanowska E, Oliveira DA, Myers KM.
  J Mech Behav Biomed Mater. 2024 Feb;150:106344.
• Light-sheet autofluorescence lifetime imaging with a single-photon avalanche diode array.
  Samimi K, Desa DE, Lin W, Weiss K, Li J, Huisken J, Miskolci V, Huttenlocher A, Chacko JV, Velten A, Rogers JD, Eliceiri KW, and Skala MC.
  J. Biomed. Opt. 28(6), 066502 (2023).
• Optical coherence tomography of human fetal membrane sub-layers during loading.
  Samimi K, Contreras Guzman E, Wu M, Carlson L, Feltovich H, Hall TJ, Myers KM, Oyen ML, and Skala MC. Biomed. Opt. Express. 2023 May 25: 14, 2969-2985.
• Microphysiological head and neck cancer model identifies novel role of lymphatically secreted monocyte migration inhibitory factor in cancer cell migration and metabolism.
  Yada RC, Desa DE, Gillette AA, Bartels E, Harari PM, Skala MC, Beebe DJ, Kerr SC.
  Biomaterials. 2023 Apr 27;298:122136.
• Inflammatory CD4/CD8 double-positive human T cells arise from reactive CD8 T cells and are sufficient to mediate GVHD pathology.
  Hess NJ, Turicek DP, Riendeau J, McIlwain SJ, Contreras Guzman E, Nadiminti K, Hudson A, Callander NS, Skala MC, Gumperz JE, Hematti P, Capitini CM.
  Sci Adv. 2023 Mar 24;9(12):eadf0567. doi: 10.1126/sciadv.adf0567. Epub 2023 Mar 24.
• Single cell metabolic imaging of tumor and immune cells in vivo in melanoma bearing mice.
  Heaton AR, Rehani PR, Hoefges A, Lopez AF, Erbe AK, Sondel PM, Skala MC.
  Frontiers in Oncology. 2023 March 20: 13

2022

• Touch-free optical technologies to streamline the production of T cell therapies.
  Gillette AA, Pham DL, Skala MC.
  Current Opinion in Biomedical Engineering. 2022 Dec 9:100434.
• Label-free optical imaging and sensing for quality control of stem cell manufacturing.
  Desa DE, Qian T, Skala MC.
  Current Opinion in Biomedical Engineering. 2022 Dec 13:100435.
• Prostate cancer cells demonstrate unique metabolism and substrate adaptability acutely after androgen deprivation therapy.
  Filon MJ, Gillette AA, Yang B, Khemees TA, Skala MC, Jarrard DF.
  Prostate. 2022 Aug 18. doi: 10.1002/pros.24428. Online ahead of print.
• Treatment Inequity: Examining the Influence of Non-Hispanic Black Race and Ethnicity on Pancreatic Cancer Care and Survival in Wisconsin
  Schiefelbein AM, Krebsbach JK, Taylor AK, Zhang J, Haimson CE, Trentham-Dietz A, Skala MC, Eason JM, Weber SM, Varley PR, Zafar SN, LoConte NK.
  Wisconsin Medical Journal. 2022 May 25.
• Inhibition of B-cell lymphoma 2 family proteins alters optical redox ratio, mitochondrial polarization, and cell energetics independent of cell state
  Gillette AA, DeStefanis RA, Pritzl SL, Deming DA, Skala MC
  J. Biomed. Opt. 2022 27(5), 056505 doi: 10.1117/1.JBO.27.5.056505.
• In situ autofluorescence lifetime assay of a photoreceptor stimulus response in mouse retina and human retinal organoids
  Samimi K, Pattnaik BR, Capowski EE, Saha K, Gamm DM, Skala MC
  Biomed. Opt. Express. 2022 13, 3476-3492 doi: 10.1364/BOE.455783.
• Label-Free Imaging to Track Reprogramming of Human Somatic Cells.
  Molugu K, Battistini GA, Heaster TM, Rouw J, Guzman EC, Skala MC, Saha K.
  GEN Biotechnol. 2022 Apr 1;1(2):176-191. doi: 10.1089/genbio.2022.0001. Epub 2022 Apr 20.
• Innate immune cell response to host-parasite interaction in a human intestinal tissue microphysiological system.
  Humayun M, Ayuso JM, Park KY, Martorelli Di Genova B, Skala MC, Kerr SC, Knoll LJ, Beebe DJ.
  Sci Adv. 2022 May 6;8(18):eabm8012. doi: 10.1126/sciadv.abm8012. Epub 2022 May 6.
• Impact of baseline culture conditions of cancer organoids when determining therapeutic response and tumor heterogeneity
  DeStafnis RA, Kratz JD, Olson AM, Sunil A, DeZeeuw AK, Gillette AA, Sha GC, Johnson KA, Pasch CA, Clipson L, Skala MC, Deming DA.
  Sci Rep 12, 5205 (2022). doi.org/10.1038/s41598-022-08937-z
• Microphysiological model of renal cell carcinoma to inform anti-angiogenic therapy.
  Virumbrales-Muñoz M, Ayuso JM, Loken JR, Denecke KM, Rehman S, Skala MC, Abel EJ, Beebe DJ.
  Biomaterials. 2022 Mar 11;283:121454. doi: 10.1016/j.biomaterials.2022.121454. Online ahead of print.
• Technologies to Assess Drug Response and Heterogeneity in Patient-Derived Cancer Organoids.
  Skala MC, Deming DA, Kratz JD.
  Annu Rev Biomed Eng. 2022 Feb 8. 24(1). doi: 10.1146/annurev-bioeng-110220-123503. PMID: 35259932
• In vivo fluorescence lifetime imaging of macrophage intracellular metabolism during wound responses in zebrafish.
  Miskolci V, Tweed KE, Lasarev MR, Britt EC, Walsh AJ, Zimmerman LJ, McDougal CE, Cronan MR, Fan J, Sauer JD, Skala MC, Huttenlocher A.
  Elife. 2022 Feb 24;11:e66080. doi: 10.7554/eLife.66080. PMID: 35200139
• Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors.
  Datta R, Sivanand S, Lau AN, Florek LV, Barbeau AM, Wyckoff J, Skala MC, Vander Heiden MG.
  Sci Adv. 2022 Jan 21;8(3):eabg6383. doi: 10.1126/sciadv.abg6383. Epub 2022 Jan 21. PMID: 35061540

2021

• Maturation- and degeneration-dependent articular cartilage metabolism via optical redox ratio imaging.
  Walsh SK, Soni R, Arendt LM, Skala MC, Henak CR.
  J Orthop Res. 2021 Nov 18.
• Breast cancer immunotherapy: current biomarkers and the potential of in vitro assays.
  Skala MC, Ayuso JM, Burkard ME, Deming DA.
  Current Opinion in Biomedical Engineering. 2021.
• Label-free imaging for quality control of cardiomyocyte differentiation.
  Qian T, Heaster TM, Houghtaling AR, Sun K, Samimi K, Skala MC.
  Nat Commun. 2021 Jul 28
• Recent innovations in fluorescence lifetime imaging microscopy for biology and medicine.
  Datta R, Gillette A, Stefely M, Skala MC.
  J. Biomed. Opt. 2021 July 10.
• Optical Coherence Tomography Angiography in the Thirteen-Lined Ground Squirrel.
  Salmon AE, Chen RC, Atry F, Gaffney M, Merriman DK, Gil DA, Skala MC, Collery R, Allen KP, Buckland E, Pashaie R, Carroll J.
  Transl Vis Sci Technol. 2021 Jul 1
• Volumetric growth tracking of patient-derived cancer organoids using optical coherence tomography.
  Gil DA, Deming DA, Skala MC.
  Biomed. Opt. Express 2021 July 1
• Extracellular pH affects the fluorescence lifetimes of metabolic co-factors.
  Schmitz R, Tweed K, Walsh C, Walsh AJ, Skala MC.
  J Biomed Opt. 2021 May
• Time-domain single photon-excited autofluorescence lifetime for label-free detection of T cell activation.
  Samimi K, Guzman EC, Trier SM, Pham DL, Qian T, Skala MC.
  Opt. Lett. 2021 April 28
• Intravital Metabolic Autofluorescence Imaging Captures Macrophage Heterogeneity Across Normal and Cancerous Tissue.
  Heaster TM, Heaton AR, Sondel PM, Skala MC.
  Front. Bioeng. Biotechnol. 2021 April 20
• Autofluorescence Imaging of Treatment Response in Neuroendocrine Tumor Organoids.
  Gillette AA, Babiarz CP, VanDommelen AR, Pasch CA, Clipson L, Matkowskyj KA, Deming DA, Skala MC.
  Cancers. 2021 April 14
• Patient-derived cancer organoid tracking with wide-field one-photon redox imaging to assess treatment response.
  Gil DA, Deming D, Skala MC.
  J Biomed Opt. 2021 Mar 22
• Microfluidic tumor-on-a-chip model to evaluate the role of tumor environmental stress on NK cell exhaustion.
  Ayuso JM, Rehman S, Virumbrales-Munoz M, McMinn PH, Geiger P, Fitzgerald C, Heaster T, Skala MC, Beebe DJ.
  Sci Adv. 2021 Feb 17
• Microfluidic model with air-walls reveals fibroblasts and keratinocytes modulate melanoma cell phenotype, migration, and metabolism.
  Ayuso JM, Sadangi S, Lares M, Rehman S, Humayun M, Denecke KM, Skala MC, Beebe DJ, Setaluri V.
  Lab Chip. 2021 Feb 3.
• Carbomer-based adjuvant elicits CD8 T-cell immunity by inducing a distinct metabolic state in cross-presenting dendritic cells.
  Lee W, Kingstad-Bakke B, Paulson B, Larsen A, Overmyer K, Marinaik CB, Dulli K, Toy R, Vogel G, Mueller KP, Tweed K, Walsh AJ, Russell J, Saha K, Reyes L, Skala MC, Sauer JD, Shayakhmetov DM, Coon J, Roy K, Suresh M.
  PLoS Pathog. 2021 Jan 14

2020

• Metabolomics revealed the influence of breast cancer on lymphatic endothelial cell metabolism, metabolic crosstalk, and lymphangiogenic signaling in co-culture
  Acevedo-Acevedo S, Millar DC, Simmons AD, Favreau P, Cobra PF, Skala M, Palecek SP.
  Sci Rep. 2020 Dec 03
• Microfluidic Tumor-on-a-Chip Model to Study Tumor Metabolic Vulnerability.
  Ayuso JM, Rehman S, Farooqui M, Virumbrales-Muñoz M, Setaluri V, Skala MC, Beebe DJ.
  Int J Mol Sci. 2020 Nov 28
• Autofluorescence imaging of 3D tumor-macrophage microscale cultures resolves spatial and temporal dynamics of macrophage metabolism.
  Heaster TM, Humayun M, Yu J, Beebe DJ, Skala MC.
  Cancer Res. 2020 Oct
• Adaptable pulsatile flow generated from stem cell-derived cardiomyocytes using quantitative imaging-based signal transduction.
  Qian T , Gil DA , Contreras Guzman E , Gastfriend BD , Tweed KE , Palecek SP , Skala MC.
  Lab Chip. 2020
• A bioengineered organotypic prostate model for the study of tumor microenvironment-induced immune cell activation.
  Kerr SC, Morgan MM, Gillette AA, Livingston MK, Lugo-Cintron KM, Favreau PF, Florek L, Johnson BP, Lang JM, Skala MC, Beebe DJ.
  Integr Biol (Camb). 2020 Oct 9
• Classification of T-cell activation via autofluorescence lifetime imaging.
  Walsh AJ, Mueller KP, Tweed K, Jones I, Walsh CM, Piscopo NJ, Niemi NM, Pagliarini DJ, Saha K, Skala MC.
  Nat Biomed Eng. 2020.
• MEK activation modulates glycolysis and supports suppressive myeloid cells in TNBC..
  Franklin DA, Sharick JT, Ericsson-Gonzalez PI, Sanchez V, Dean PT, Opalenik SR, Cairo S, Judde JG, Lewis MT, Chang JC, Sanders ME, Cook RS, Skala MC, Bordeaux J, Orozco Bender J, Vaupel C, Geiss G, Hinerfeld D, Balko JM.
  JCI Insight. 2020.
• Fluorescence lifetime imaging microscopy: fundamentals and advances in instrumentation, analysis, and applications
  Datta R, Heaster TM , Sharick JT , Gillette AA , Skala MC.
  J Biomed Opt, 2020
• Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment
  Sharick JT , Walsh CM, Sprackling CM, Pasch CA, Pham DL, Esbona K, Choudhary A, Garcia-Valera R, Burkard ME, McGregor SM, Matkowskyj KA, Parikh AA, Meszoely IM, Kelley MC, Tsai S, Deming DA, and Skala MC.
  Front Oncol, 2020
• Label-free redox imaging of patient-derived organoids using selective plane illumination microscopy
  Favreau PF, He J, Gil DA, Deming DA, Huisken J, Skala MC
  Biomed Opt Exp 2020.
• Human Tumor‐Lymphatic Microfluidic Model Reveals Differential Conditioning of Lymphatic Vessels by Breast Cancer Cells
  Ayuso JM, Gong MM, Skala MC, Harari PM, Beebe DJ
  Advanced healthcare materials. 2020 January.

2019

• Development of a Microfluidic Array to Study Drug Response in Breast Cancer.
  Virumbrales-Muñoz M, Livingston MK, Farooqui M, Skala MC, Beebe DJ, Ayuso JM
  Molecules. 2019 Nov 30;24(23). pii: E4385. doi: 10.3390/molecules24234385.
• Quantitative Spatial Analysis of Metabolic Heterogeneity Across in vivo and in vitro Tumor Models
  Heaster TM, Landman BA, Skala MC
  Front. Oncol., 01 November 2019. doi: fonc.2019.01144
• Classifying T cell activity in autofluorescence intensity images with convolutional neural networks
  Wang ZJ, Walsh AJ, Skala MC, Gitter A
  J Biophotonics. 2019 Oct 29. doi: 10.1002/jbio.201960050.
• Sample Preparation Strategies for High-Throughput Mass Spectrometry Imaging of Primary Tumor Organoids
  Johnson J, Sharick JT, Skala MC, Li L
  Journal of mass spectrometry: JMS, 2019 Oct 29. doi: 10.1002/jms.4452
• Real-time optical redox imaging of cartilage metabolic response to mechanical loading
  Walsh SK, Skala MC, Henak CR
  Osteoarthritis Cartilage. 2019 Sep 9. pii: S1063-4584(19)31190-2. doi: 10.1016/j.joca.2019.08.004.
• Tumor-on-a-chip: a microfluidic model to study cell response to environmental gradients
  Ayuso JM, Virumbrales-Munoz M, McMinn PH, Rehman S, Gomez I, Karim MR, Trusttchel R, Wisinski KB, Beebe DJ, Skala MC
  Lab Chip. 2019 Sep 11. doi: 10.1039/c9lc00270g.
• Effects of culture method on response to EGFR therapy in head and neck squamous cell carcinoma cells
  Ayuso JM, Vitek R, Swick AD, Skala MC, Wisinski KB, Kimple RJ, Lambert PF, Beebe DJ
  Sci Rep. 2019 Aug 28;9(1):12480. doi: 10.1038/s41598-019-48764-3.
• Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
  Pasch CA, Favreau PF, Yueh AE, Babiarz CP, Gillette AA, Sharick JT, Karim MR, Nickel KP, DeZeeuw AK, Sprackling CM, Emmerich PB, DeStefanis RA, Pitera RT, Payne SN, Korkos DP, Clipson L, Walsh CM, Miller D, Carchman EH, Burkard ME, Lemmon KK, Matkowskyj KA, Newton MA, Ong IM, Bassetti MF, Kimple RJ, Skala MC, Deming DA
  Clin Cancer Res. 2019 Jun 7. doi: 10.1158/1078-0432.CCR-18-3590.
• Cellular Metabolic Heterogeneity In Vivo Is Recapitulated in Tumor Organoids
  Sharick JT, Jeffery JJ. Karim MR, Walsh CM, Esbona K, Cook RS, Skala MC
  Neoplasia 21:6, June 2019, Pg 615-626. doi: 10.1016/j.neo.2019.04.004
• Imaging intratumoral metabolic heterogeneity
  Walsh AJ, Sharick JT, Skala MC
  Nature BME: News & Views. 3, 333–334 (2019). doi: 10.1038/s41551-019-0398-z
• Redox imaging and optical coherence tomography of the respiratory ciliated epithelium
  Gil DA, Sharick JT, Mancha S, Gamm UA, Choma MA, Skala MC
  J Biomed Opt. 2019 Jan 30. doi: 10.1117/1.JBO.24.1.010501.

2018

• Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines
  Capowski EE, Samimi K, Mayerl SJ, Phillips MJ, Pinilla I, Howden SE, Saha J, Jansen AD, Edwards KL, Jager LD, Barlow K, Valiauga R, Erlichman Z, Hagstrom A, Sinha D, Sluch VM, Chamling X, Zack DJ, Skala MC, Gamm DM
  Development. 2018 Dec 19. doi: 10.1242/dev.171686.
• Quantitative Label-Free Imaging of 3D Vascular Networks Self-Assembled in Synthetic Hydrogels
  Kaushik G, Gil DA, Torr E, Berge ES, Soref C, Uhl P, Fontana G, Antosiewicz-Bourget J, Edington C, Schwartz MP, Griffith LG, Thomson JA, Skala MC, Daly WT, Murphy WL
  Adv Healthc Mater. 2018 Dec 19 doi: 10.1002/adhm.201801186.
• Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model
  Ayuso JM, Truttschel R, Gong MM, Humayun M, Virumbrales-Munoz M, Vitek R, Felder M, Gillies SD, Sondel P, Wisinski KB, Patankar M, Beebe DJ, Skala MC
  OncoImmunology (2018) DOI: 10.1080/2162402X.2018.1553477
• Imaging retinal melanin: a review of current technologies
  Lapierre-Landry M, Carroll J, Skala MC
  J Biol Eng. (2018) Dec 4;12:29. doi: 10.1186/s13036-018-0124-5.
• MTORC1/2 inhibition as a therapeutic strategy for PIK3CA mutant cancers
  Fricke SL, Payne SN, Favreau PF, Kratz JD, Pasch CA, Foley TM, Yueh AE, Van De Hey DR, Depke MG, Korkos DP, Sha GC, DeStefanis RA, Clipson L, Burkard ME, Lemmon KK, Parsons BM, Kenny PA, Matkowskyj KA, Newton MA, Skala MC, Deming DA
  Mol Cancer Ther. (2018) Nov 13. doi: 10.1158/1535-7163.MCT-18-0510.
• BET inhibitors reduce cell size and induce reversible cell cycle arrest in AML
  Zhang S, Zhao Y, Heaster TM, Fischer MA, Stengel KR, Zhou X, Ramsey H, Zhou MM, Savona MR, Skala MC, Hiebert SW
  J Cell Biochem. (2018) Nov 11. doi: 10.1002/jcb.28005.
• Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations
  Ayuso JM, Gillette A, Lugo-Cintrón K, Acevedo-Acevedod S, Gomez I, Morgan M, Heaster T, Wisinski KB, Palecek SP, Skala MC, Beebe DJ
  EBioMedicine (2018) doi: 10.1016/j.ebiom.2018.10.046
• Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography
  Lapierre-Landry M, Huckenpahler AL, Link BA, Collery RF, Carroll J, Skala MC
  Transl Vis Sci Technol. 2018 Sep 4;7(5):4. doi: 10.1167/tvst.7.5.4.
• Photothermal optical coherence tomography of indocyanine green in ex vivo eyes
  Lapierre-Landry M, Connor TB, Carroll J, Tao YK, Skala MC
  Opt Lett. 2018 Vol. 43, Issue 11, pp. 2470-2473. doi: 10.1364/OL.43.002470.
• Protein-bound NAD(P)H Lifetime is Sensitive to Multiple Fates of Glucose Carbon
  Sharick JT, Favreau PF, Gillette AA, Sdao SM, Merrins MJ, Skala MC
  Scientific Reports (2018) Vol. 8, Article number: 5456. doi:10.1038/s41598-018-23691-x
• Quantifying optical properties with visible and near-infrared optical coherence tomography to visualize esophageal microwave ablation zones
  Niemeier RC, Etoz S, Gil DA, Skala MC, Brace CL, and Rogers JD. Biomed
  Opt. Express. 2018 9(4) 1648-1663. doi: 10.1364/BOE.9.001648
• Oxidative stress via inhibition of the mitochondrial electron transport and Nrf-2-mediated anti-oxidative response regulate the cytotoxic activity of plumbagin
  Kapur A, Beres T, Rathi K, Nayak AP, Czarnecki A, Felder M, Gillette A, Ericksen SS, Sampene E, Skala MC, Barroilhet L, Patankar MS
  Sci Rep. 2018 Jan 18;8(1):1073. doi: 10.1038/s41598-018-19261-w.
• Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells
  Zhang Q, Jeppesen DK, Higginbotham JN, Demory Beckler M, Poulin EJ, Walsh AJ, Skala MC, McKinley ET, Manning HC, Hight MR, Schulte ML, Watt KR, Ayers GD, Wolf MM, Andrejeva G, Rathmell JC, Franklin JL, Coffey RJ.
  Cell Mol Gastroenterol Hepatol. 2018 Jan 31;5(4):627-629.e6. doi: 10.1016/j.jcmgh.2018.01.013
• Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models
  Schulte ML, Fu A, Zhao P, Li J, Geng L, Smith ST, Kondo J, Coffey RJ, Johnson MO, Rathmell JC, Sharick JT, Skala MC, Smith JA, Berlin J, Washington MK, Nickels ML, Manning HC
  Nat Med. 2018 Jan 15. doi: 10.1038/nm.4464.

2017

• Drug-Free ROS Sponge Polymeric Microspheres Reduce Tissue Damage from Ischemic and Mechanical Injury
  O’Grady KP, Kavanaugh TE, Cho H, Ye H, Gupta MK, Madonna MC, Lee J, O’Brien CM, Skala MC, Hasty KA, Duvall CL
  ACS Biomaterials Science & Engineering. 2017 Apr 6. DOI: 10.1021/acsbiomaterials.6b00804
• Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension
  Egnatchik RA, Brittain EL, Shah AT, Fares WH, Ford HJ, Monahan K, Kang CJ, Kocurek EG, Zhu S, Luong T, Nguyen TT, Hysinger E, Austin ED, Skala MC, Young JD, Roberts LJ 2nd, Hemnes AR, West J, Fessel JP
  Pulm Circ. 2017 Feb 1;7(1):186-199. doi: 10.1086/690236.
• In vivo photothermal optical coherence tomography of endogenous and exogenous contrast agents in the eye
  Lapierre-Landry M, Gordon AY, Penn JS, and Skala MC
  Scientific Reports 7, Article number: 9228 (2017). doi:10.1038/s41598-017-10050-5
• Functional Optical Imaging of Primary Human Tumor Organoids for Personalized Drug Screens
  Walsh AJ, Cook RS, Skala MC
  J Nucl Med. (2017) Jun 6. doi: 10.2967/jnumed.117.192534.
• Autofluorescence imaging identifies tumor cell-cycle status on a single-cell level
  Heaster TM, Walsh AJ, Zhao Y, Hiebert SW, Skala MC
  J Biophotonics. (2017) May 9. doi: 10.1002/jbio.201600276
• Autofluorescence imaging captures heterogeneous drug response differences between 2D and 3D breast cancer cultures
  Cannon TM, Shah AT, Skala MC
  Biomed. Opt. Express (2017) 8, 1911-1925 doi: 10.1364/BOE.8.001911
• Metabolic Imaging of Head and Neck Cancer Organoids
  Shah AT, Heaster TM, Skala MC
  Metabolic Imaging of Head and Neck Cancer Organoids. (2017) PLoS ONE 12(1): e0170415. doi:10.1371/journal.pone.0170415

2016

• Copolymer-mediated cell aggregation promotes a proangiogenic stem cell phenotype in vitro and in vivo
  Crowder SW, Balikov DA, Boire TC, McCormack D, Lee JB, Gupta MK, Skala MC, Sung H-J
  Adv. Healthcare Mater. 2016 Sep.;  doi: 10.1002/adhm.201600819.
• Autofluorescence flow sorting of breast cancer cell metabolism
  Shah AT, Cannon TM, Higginbotham JN, Coffey RJ, Skala MC
  J. Biophotonics. 2016 Oct.;  doi: 10.1002/jbio.201600128.
• Depth-resolved analytical model and correction algorithm for photothermal optical coherence tomography
  Lapierre-Landry M, Tucker-Schwartz JM, Skala M
  Biomedical optics express. 2016; 7(7):2607-22.
• Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response
  Walsh AJ, Castellanos JA, Nagathihalli NS, Merchant NB, Skala MC
  Pancreas. 2016 Jul;45(6):863-9. doi: 10.1097/MPA.0000000000000543.
• Temporal binning of time-correlated single photon counting data improves exponential decay fits and imaging speed
  Walsh AJ, Sharick JT, Skala MC, Beier HT.
  Biomedical optics express. 2016; 7(4):1385-99.
• Drug response in organoids generated from frozen primary tumor tissues
  Walsh AJ, Cook RS, Sanders ME, Arteaga CL, Skala MC
  Sci Rep. 2016 Jan 7;6:18889. doi: 10.1038/srep18889.

2015

• In Vivo Autofluorescence Imaging of Tumor Heterogeneity in Response to Treatment
  Shah AT, Diggins KE, Walsh AJ, Irish JM, Skala MC
  Neoplasia. 2015 Dec;17(12):862-70. doi: 10.1016/j.neo.2015.11.006.
• Deconvolution of fluorescence lifetime imaging microscopy by a library of exponentials
  Campos-Delgado DU, Navarro OG, Arce-Santana ER, Walsh AJ, Skala MC, Jo JA
  Opt Express. 2015 Sep 7;23(18):23748-67. doi: 10.1364/OE.23.023748.
• Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer
  Nagathihalli NS, Castellanos JA, Shi C, Beesetty Y, Reyzer ML, Caprioli R, Chen X, Walsh AJ, Skala MC, Moses HL, Merchant NB
  Gastroenterology. 2015 Dec;149(7):1932-1943.e9. doi: 10.1053/j.gastro.2015.07.058. Epub 2015 Aug 7.
• Blind deconvolution estimation of fluorescence measurements through quadratic programming
  Campos-Delgado DU, Gutierrez-Navarro O, Arce-Santana ER, Skala MC, Walsh AJ, Jo JA
  J Biomed Opt. 2015 Jul;20(7):075010. doi: 10.1117/1.JBO.20.7.075010.
• Photothermal optical lock-in optical coherence tomography for in vivo imaging
  Tucker-Schwartz JM, Lapierre-Landry M, Patil CA, Skala MC
  Biomed Opt Express. 2015 May 27;6(6):2268-82. doi: 10.1364/BOE.6.002268. eCollection 2015 Jun 1.
• ROS-responsive microspheres for on demand antioxidant therapy in a model of diabetic peripheral arterial disease
  Poole KM, Nelson CE, Joshi RV, Martin JR, Gupta MK, Haws SC, Kavanaugh TE, Skala MC, Duvall CL
  Biomaterials. 2015 41:166-75. NIHMSID: NIHMS642415
• Optical metabolic imaging quantifies heterogeneous cell populations
  Walsh AJ, Skala MC
  Biomed Opt Express. 2015 Jan 15;6(2):559-73. doi: 10.1364/BOE.6.000559. eCollection 2015 Feb 1.
• Collagen density and alignment in responsive and resistant trastuzumab-treated breast cancer xenografts
  Walsh AJ, Cook RS, Lee JH, Arteaga CL, Skala MC
  J Biomed Opt. 2015 Feb;20(2):26004. doi: 10.1117/1.JBO.20.2.026004.
• High-throughput measurements of the optical redox ratio using a commercial microplate reader
  Cannon TM, Shah AT, Walsh AJ, Skala MC
  J Biomed Opt. 2015 Jan;20(1):010503. doi: 10.1117/1.JBO.20.1.010503.

2014

• Uncoupling angiogenesis and inflammation in peripheral artery disease with therapeutic peptide-loaded microgels
  Zachman AL, Wang X, Tucker-Schwartz JM, Fitzpatrick ST, Lee SH, Guelcher SA, Skala MC, Sung HJ
  Biomaterials. 2014; 35(36):9635-48. NIHMSID: NIHMS624426
• Quantifying the vascular response to ischemia with speckle variance optical coherence tomography
  Poole KM, McCormack DR, Patil CA, Duvall CL, Skala MC
  Biomedical optics express. 2014; 5(12):4118-30.
• Quantitative optical imaging of primary tumor organoid metabolism predicts drug response in breast cancer
  Walsh AJ, Cook RS, Sanders ME, Aurisicchio L, Ciliberto G, Arteaga CL, Skala MC
  Cancer research. 2014; 74(18):5184-94. NIHMSID: NIHMS617855
• In vivo hyperspectral imaging of microvessel response to trastuzumab treatment in breast cancer xenografts
  McCormack DR, Walsh AJ, Sit W, Arteaga CL, Chen J, Cook RS, Skala MC
  Biomedical optics express. 2014; 5(7):2247-61.
• In vivo imaging of nanoparticle delivery and tumor microvasculature with multimodal optical coherence tomography
  Tucker-Schwartz JM, Beavers KR, Sit WW, Shah AT, Duvall CL, Skala MC
  Biomedical optics express. 2014; 5(6):1731-43.
• The NADH oxidase ENOX1, a critical mediator of endothelial cell radiosensitization, is crucial for vascular development
  Venkateswaran A, Sekhar KR, Levic DS, Melville DB, Clark TA, Rybski WM, Walsh AJ, Skala MC, Crooks PA, Knapik EW, Freeman ML.
  Cancer research. 2014; 74(1):38-43. NIHMSID: NIHMS543105
• Optical metabolic imaging of treatment response in human head and neck squamous cell carcinoma
  Shah AT, Demory Beckler M, Walsh AJ, Jones WP, Pohlmann PR, Skala MC
  PloS one. PloS one. 2014; 9(3):e90746.

2013

• Quantitative optical imaging of vascular response in vivo in a model of peripheral arterial disease
  Poole KM, Tucker-Schwartz JM, Sit WW, Walsh AJ, Duvall CL, Skala MC
  American journal of physiology. Heart and circulatory physiology. 2013; 305(8):H1168-80.
• Optical metabolic imaging identifies glycolytic levels, subtypes, and early-treatment response in breast cancer
  Walsh AJ, Cook RS, Manning HC, Hicks DJ, Lafontant A, Arteaga CL, Skala MC
  Cancer research. 2013; 73(20):6164-74. NIHMSID: NIHMS515760
• The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins
  Venkateswaran A, Friedman DB, Walsh AJ, Skala MC, Sasi S, Rachakonda G, Crooks PA, Freeman ML, Sekhar KR
  Investigational new drugs. 2013; 31(3):535-44. NIHMSID: NIHMS413695
• Cross-sectional tracking of particle motion in evaporating drops: flow fields and interfacial accumulation
  Trantum JR, Eagleton ZE, Patil CA, Tucker-Schwartz JM, Baglia ML, Skala MC, Haselton FR
  Langmuir: the ACS journal of surfaces and colloids. 2013; 29(21):6221-31. NIHMSID: NIHMS792311
• Dual pH- and temperature-responsive microparticles for protein delivery to ischemic tissues
  Joshi RV, Nelson CE, Poole KM, Skala MC, Duvall CL
  Acta biomaterialia. 2013; 9(5):6526-34. NIHMSID: NIHMS445461
• Three-dimensional molecular imaging with photothermal optical coherence tomography
  Skala MC, Crow MJ, Wax A, Izatt JA.
  Methods in molecular biology. 2013; 1026:85-92. NIHMSID: NIHMS697574

2012

• In vivo photothermal optical coherence tomography of gold nanorod contrast agents
  Tucker-Schwartz JM, Meyer TA, Patil CA, Duvall CL, Skala MC
  Biomedical optics express. 2012; 3(11):2881-95.
• Ex vivo optical metabolic measurements from cultured tissue reflect in vivo tissue status
  Walsh AJ, Poole KM, Duvall CL, Skala MC
  Journal of biomedical optics. 2012; 17(11):116015.
• Dual-modality photothermal optical coherence tomography and magnetic-resonance imaging of carbon nanotubes
  Tucker-Schwartz JM, Hong T, Colvin DC, Xu Y, Skala MC
  Optics letters. 2012; 37(5):872-4. NIHMSID: NIHMS388212
• Optical imaging of metabolism in HER2 overexpressing breast cancer cells Walsh A, Cook RS, Rexer B, Arteaga CL, Skala MC
  Biomedical optics express. 2012; 3(1):75-85.

2004 – 2011

• Longitudinal optical imaging of tumor metabolism and hemodynamics
  Skala MC, Fontanella A, Lan L, Izatt JA, Dewhirst MW.
  Journal of biomedical optics. 2010; 15(1):011112.
• Multiphoton redox ratio imaging for metabolic monitoring in vivo
  Skala M, Ramanujam N
  Methods in molecular biology. 2010; 594:155-62. NIHMSID: NIHMS201646
• Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging
  Skala MC, Fontanella A, Hendargo H, Dewhirst MW, Izatt JA
  Optics letters. 2009; 34(3):289-91. NIHMSID: NIHMS122921
• Photothermal optical coherence tomography of epidermal growth factor receptor in live cells using immunotargeted gold nanospheres
  Skala MC, Crow MJ, Wax A, Izatt JA.
  Nano letters. 2008; 8(10):3461-7. NIHMSID: NIHMS68839
• In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia
  Skala MC, Riching KM, Gendron-Fitzpatrick A, Eickhoff J, Eliceiri KW, White JG, Ramanujam N
  Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(49):19494-9.
• Comparison of a physical model and principal component analysis for the diagnosis of epithelial neoplasias in vivo using diffuse reflectance spectroscopy
  Skala MC, Palmer GM, Vrotsos KM, Gendron-Fitzpatrick A, Ramanujam N
  Optics express. 2007; 15(12):7863-75. NIHMSID: NIHMS24764
• In vivo multiphoton fluorescence lifetime imaging of protein-bound and free nicotinamide adenine dinucleotide in normal and precancerous epithelia
  Skala MC, Riching KM, Bird DK, Gendron-Fitzpatrick A, Eickhoff J, Eliceiri KW, Keely PJ, Ramanujam N
  Journal of biomedical optics. 2007; 12(2):024014. NIHMSID: NIHMS122928
• Multiphoton microscopy of endogenous fluorescence differentiates normal, precancerous, and cancerous squamous epithelial tissues
  Skala MC, Squirrell JM, Vrotsos KM, Eickhoff JC, Gendron-Fitzpatrick A, Eliceiri KW, Ramanujam N
  Cancer research. 2005; 65(4):1180-6. NIHMSID: NIHMS485459
• Investigation of fiber-optic probe designs for optical spectroscopic diagnosis of epithelial pre-cancers
  Skala MC, Palmer GM, Zhu C, Liu Q, Vrotsos KM, Marshek-Stone CL, Gendron-Fitzpatrick A, Ramanujam N.
  Lasers in surgery and medicine. 2004; 34(1):25-38. NIHMSID: NIHMS122929