Fan Lab

The Fan lab is interested in understanding how mammalian cellular metabolism is reprogrammed in response to changes in cellular state and environments, and how activities in key metabolic pathways can affect cell physiology.

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Mammalian cellular metabolism is dynamically regulated in response to changes in cellular state and function and to perturbations in the environment. We integrate metabolomics, lipidomics and metabolic flux analysis with biochemical, genetic, and computational tools to understand metabolism. We are particularly interested in metabolic reprogramming that occurs in specific situations relevant to human health, including the dynamic metabolic remodeling during immune cell activation, and the metabolic adaptations in cancer cells to a stressful tumor microenvironment. We further investigate the mechanisms by which the specific changes in metabolic state can affect cell function, signal, physiology and survival. Understanding this process will bring insights into fundamental questions regarding metabolic regulation, as well as promote the development of metabolic intervention for various diseases.

Fan Lab

Career Opportunities

We are currently recruiting postdoctoral fellows and graduate students.

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Principal Investigator Jing Fan

Jing Fan is a metabolism investigator at the Morgridge Investigator for Research, and an associate professor in the Department of Nutritional Science (affiliate: Department of Biochemistry) at the University of Wisconsin–Madison. She is a member of the University of Wisconsin Carbone Cancer Center. Jing Fan is a faculty trainer in Cellular and Molecular Biology (CMB), Nutrition and Metabolism Graduate Program, Integrated Program in Biochemistry (IPiB), Cellular and Molecular Pathology (CMP), and Molecular and Cellular Pharmacology (MCP). She has broad interests in metabolism, particularly in metabolic regulation in immune and cancer cells.

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