While refining ways to grow arterial endothelial cells in the lab, a regenerative biology team at the Morgridge Institute for Research unexpectedly unearthed a powerful new model for studying a hallmark of vascular disease.
Not all monsters lurk in the closet, hide under the bed, or go bump in the night; in fact, they are all around us. In basic research, you can find tapeworms who thrive on the blood of their animal hosts – or the limb-generating axolotl, a water amphibian whose very name means “water monster.”
New techniques developed at the Morgridge Institute for Research and the University of Wisconsin-Madison have produced, for the first time, functional arterial cells at both the quality and scale to be relevant for disease modeling and clinical application.
With about 100 lines of code, a Morgridge Institute for Research team has unleashed a fast, simple and predictive text-mining tool that may turbo-charge big biomedical pursuits such as drug repurposing and stem cell treatments.
The mystery of what controls the range of developmental clocks in mammals — from 22 months for an elephant to 12 days for a opossum — may lie in the strict time-keeping of pluripotent stem cells for each unique species.