Positive-strand RNA viruses constitute many clinically relevant pathogens, including Hepatitis C, SARS, zika-, Dengue, and poliovirus. A common feature of this group of viruses is that, upon infection, the first proteins expressed restructure the host intracellular membranes to from viral replication compartments. I am specifically interested in studying the structural features of these multifunctional proteins. […]
I use various techniques in electron microscopy, including cryo-electron tomography, to study Flock House virus and Sindbis virus. Education M.S. Botany, 1985, Oklahoma State University B.S. Biology, 1979, Oklahoma State University
I analyze the viral evolutionary record to identify the protein-protein interactions that constitute the viral replication complex.
I study cellular proteins ZASC and ZBTB2 and their role in HIV transcription. Education M.S. Clinical Microbiology, 2011, University of Wisconsin-La Crosse B.S. Biology, 2008, University of Wisconsin-La Crosse Publications ZASC1 stimulates HIV-1 transcription elongation by recruiting P-TEFb and TAT to the LTR promoter. Bruce JW, Reddington R, Mathieu E, Bracken M, Young JA, Ahlquist […]
I assist in developing tools to study the structure and function of Alphavirus replication complexes.