Our lab studies how viruses take over cells, amplify themselves and cause certain diseases, including ~15% of human cancers. Viruses remain one of the greatest public health challenges, as shown by COVID-19, HIV-AIDS, Ebola and accelerating dangers of further pandemics from a wide range of other viruses. In parallel, viruses are a major source of insights into normal cell biology, and provide expanding tools for biomedicine, biotechnology and nanotechnology. By revealing the molecular mechanisms underlying many aspects of virus function, our studies are providing new foundations for improved, broader spectrum antiviral controls, and for more effective use of viruses and their genes for beneficial purposes.