Publications

Original reports

• Flickinger KM, Wilson KM, Rossiter NJ, Hunger AL, Vishwasrao PV, Lee TD, Mellado Fritz CA,  Richards RM, Hall MD, and Cantor JR. Conditional lethality profiling reveals anticancer mechanisms of action and drug-nutrient interactions. Sci Adv. 10, eadq3591 (2024). PMCID: PMC11451515.
• MacPherson S, Keyes S, Kilgour M, Smazynski J, Chan V, Sudderth J, Turcotte T, Devlieger A, Yu J, Huggler KS, Cantor JR, DeBerardinis RJ, Siatskas C, and Lum, J. Clinically-relevant T cell expansion media activate distinct metabolic programs uncoupled from cellular function. Mol Ther Methods Clin Dev., 24, 380-393 (2022). PMCID: PMC8897702.
• Rossiter NJ, Huggler KS, Adelmann CH, Keys HR, Soens RW, Sabatini DM, and Cantor JR. CRISPR screens in physiologic medium reveal conditionally essential genes in human cells. Cell Metab. 33, 1248-1263.e9 (2021). PMCID: PMC8172426.
• Williams RT, Guarecuco R, Gates LA, Barrows D, Passarelli MC, Carey B, Baudrier L, Jeewajee S, La K, Prizer B, Malik S, Garcia-Bermudez J, Zhu XG, Cantor JR, Molina H, Carroll T, Roeder RG, Abdel-Wahab O, Allis CD, and Birsoy, K. ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase. Cell Metab. 31, 852-861 (2020). PMCID: PMC7219601.
• Leney-Greene MA, Boddapati AK, Su HC, Cantor JR*, and Lenardo, MJ* Human plasma-like medium improves T lymphocyte activation. iScience 23:100759 (2020). PMCID: PMC6941860. *joint senior author
• Kanarek N, Keys HR, Cantor JR, Abu-Remaileh M, Freinkman E, Lewis CA, Chan SH, Kunchok T, Schweitzer LD, and Sabatini, DM. Histidine catabolism is a major determinant of methotrexate sensitivity. Nature 559, 632-636 (2018). PMCID: PMC6082631.
• Cantor JR, Abu-Remaileh M, Kanarek N, Freinkman E, Gao X, Louissaint A, Lewis CA, and Sabatini, DM. Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase. Cell 169, 258-272 (2017). PMCID: PMC5421364.
  -This work is in the directory of Faculty Opinions recommended articles
• Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, and Sabatini, DM. Sestrin2 is a leucine sensor for the mTORC1 pathway. Science 351, 43-8 (2016). PMCID: PMC4698017.
  -This work is in the directory of Faculty Opinions recommended articles
• Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, and Sabatini, DM. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature 520, 363-7 (2015). PMCID: PMC4533874.
• Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato RL, Reinhardt F, Weinberg RA, Yaffe MB, and Sabatini DM. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell 158, 1094-109 (2014). PMCID: PMC4250222.
• Li W, Cantor JR, Yogesha SD, Yang S, Chantranupong L, Liu JQ, Agnello G, Georgiou G, Stone EM, and Zhang, Y. Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation. ACS Chem Biol. 7, 1840-7 (2012). PMCID: PMC3514461.
• Cantor JR, Stone EM, and Georgiou, G. Expression and biochemical characterization of the human enzyme N-terminal asparagine amidohydrolase. Biochemistry 50, 3025-33 (2011). PMCID: PMC3085321.
• Cantor JR, Yoo TH, Dixit, A, Iverson BL, Forsthuber TG, and Georgiou, G. Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift. Proc Natl Acad Sci USA 108, 1272-1277 (2011). PMCID: PMC3029727.
• Cantor JR, Stone EM, Chantranupong L, and Georgiou G. The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity. Biochemistry 48, 11026-31 (2009). PMCID: PMC2782781.
• Varadarajan N, Cantor JR, Georgiou G, and Iverson BL. Construction and flow cytometric screening of targeted enzyme libraries. Nat Protoc. 4, 893-901 (2009). PMID: 19478805.
• Camarero JA, Kimura RH, Woo YH, Shektman A, and Cantor, JR. Biosynthesis of a fully functional cyclotide inside living bacterial cells. Chembiochem 8, 1363-6 (2007). PMID: 17590879.
• Finehout EJ, Cantor JR, and Lee KH. Kinetic characterization of sequencing grade modified trypsin. Proteomics 5, 2319-21 (2005). PMID: 15880790.

Reviews and perspectives

• Ta J, Kunzmann GB, Virtue S, Cantor JR**, and Fazakerley DJ** Seeing the world through the eyes of cultured cells. Cell Metab. (online ahead of print). **joint corresponding author
• Kaymak I, Williams KS, Cantor JR*, and Jones RG* Immunometabolic Interplay in the Tumor Microenvironment. Cancer Cell 39, 28-37 (2021).  PMCID: PMC7837268. *joint senior author
• Cantor JR. The Rise of Physiologic Media. Trends Cell Biol. 29, 854-861 (2019). PMCID: PMC7001851.
  -Cover feature
  -This piece was selected as a Trends Editors’ Pick (December 2019)
• Cantor JR and Sabatini DM. Cancer cell metabolism: one hallmark, many faces. Cancer Discov. 2, 881-98 (2012). PMCID: PMC3491070.

Book chapters

• Huggler KS, Rossiter NJ, Flickinger KM, and Cantor JR. CRISPR/Cas9 screening to identify conditionally essential genes in human cell lines. Methods Mol Biol. 2377, 29-42 (2022). PMID: 34709609.
• Paley O, Agnello G, Cantor JR, Yoo TH, Georgiou G, and Stone, EM. GFP reporter screens for the engineering of amino acid degrading enzymes from libraries expressed in bacteria. Methods Mol Biol. 978, 31-44 (2013). PMCID: PMC3910379.
• Cantor JR, Panayiotou V, Agnello G, Georgiou G, and Stone EM. Engineering reduced immunogenicity enzymes for amino acid depletion therapy in cancer. Methods Enzymol. 502, 291-319 (2012). PMID: 22208990.

Preprints not yet published

• Huggler KS, Mellado Fritz CA, Flickinger KM, Chang GR, McGuire MF, and Cantor JR. Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production. bioRxiv doi: 10.1101/2025.02.07.637120
• Tharp KM, Park S, Timblin GA, Richards AL, Berg JA, Twells NM, Riley NM, Peltan EL, Shon DJ, Stevenson E, Tsui K, Palomba F, Lefebvre AEYT, Soens RW, Ayad NME, ten Hoeve-Scott J, Healy K, Digman M, Dillin A, Bertozzi CR, Swaney DL, Mahal LK, Cantor JR, Paszek MJ, and Weaver VM. The microenvironment dictates glycocalyx construction and immune surveillance. bioRxiv doi: https://doi.org/10.1101/2023.06.23.546317.