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2022
- MacPherson, S, Keyes, S, Kilgour, M, Smazynski, J, Chan, V, Sudderth, J, Turcotte, T, Devlieger, A, Yu, J, Huggler, KS, Cantor, JR, DeBerardinis, RJ, Siatskas, C & Lum, J Clinically-relevant T cell expansion media activate distinct metabolic programs uncoupled from cellular function. Mol Ther Methods Clin Dev, 24, 380-393.
- Huggler, KS*, Rossiter, NJ*, Flickinger, KM & Cantor, JR CRISPR/Cas9 Screening to Identify Conditionally Essential Genes in Human Cell Lines Methods Mol Biol, 2377, 29-42
2021
- Rossiter NJ, Huggler, KS, Adelmann CH, Keys HR, Soens RW, Sabatini DM* & Cantor, JR*. (2021) CRISPR screens in physiologic medium reveal conditionally essential genes in human cells. Cell Metab, 33, 1248-1263.e9
*Co-corresponding - Kaymak, I, Williams, KS, Cantor, JR* & Jones, RG.* (2021) Immunometabolic Interplay in the Tumor Microenvironment. Cancer Cell, 39, 28-37
*Co-corresponding
2020
- Leney, Greene, MA, Boddapati, AK, Su, HC, Cantor, JR* & Lenardo, MJ* (2020) Human plasma-like medium improves T lymphocyte activation. iScience 23, 100759.
*Co-corresponding - Williams RT, Guarecuco R, Gates LA, Barrows D, Passarelli MC, Carey B, Baudrier L, Jeewajee S, La K, Prizer B, Malik S, Garcia-Bermudez J, Zhu XG, Cantor JR, Molina H, Carroll T, Roeder RG, Abdel-Wahab O, Allis CD, Birsoy K. (2020) ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase. Cell Metab 3, 852-861.e6.
2019
- Cantor, JR (2019) The Rise of Physiologic Media. Trends Cell Biol. 29, 854-861.
Selected for cover feature and Trends’ Editors Pick (December 2019)
2012-2018
- Kanarek N, Keys HR, Cantor JR, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Freinkman E, Schweitzer LD, Sabatini DM. (2018) Histidine catabolism is a major determinant of methotrexate sensitivity. Nature 559, 632-636.
- Cantor JR, Abu-Remaileh M, Kanarek N, Freinkman E, Gao X, Louissaint A Jr, Lewis CA, Sabatini DM. (2017) Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase. Cell 169, 258-272
Recommended by Faculty Opinions (formerly F1000 Prime) - Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM. (2016) Sestrin2 is a leucine sensor for the mTORC1 pathway. Science 351, 43-48
Recommended by Faculty Opinions (formerly F1000 Prime) - Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM. (2015) SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature 520, 363-367
- Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM. (2014) Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell 158, 1094-1109
- Paley O, Agnello G, Cantor JR, Yoo TH, Georgiou G, Stone E. (2013) GFP reporter screens for the engineering of amino acid degrading enzymes from libraries expressed in bacteria. Methods Mol Biol. 978, 31-44
- Li W, Cantor JR, Yogesha SD, Yang S, Chantranupong L, Liu JQ, Agnello G, Georgiou G, Stone EM, Zhang Y. (2012) Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation. ACS Chem Biol. 16, 1840-1847
- Cantor, JR and Sabatini, DM Cancer cell metabolism: one hallmark, many faces. Cancer Discov., 2, 881-98 (2012).
- Cantor, JR, Panayiotou, V., Agnello, G., Georgiou, G., and Stone, EM Engineering reduced immunogenicity enzymes for amino acid depletion therapy in cancer. Methods Enzymol., 502, 291-319 (2012)
Pre 2012
- Cantor JR, Stone EM, Georgiou G. (2011) Expression and biochemical characterization of the human enzyme N-terminal asparagine amidohydrolase. Biochemistry 50, 3025-3033
- Cantor JR, Yoo TH, Dixit A, Iverson BL, Forsthuber TG, Georgiou G. (2011) Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift. Proc Natl Acad Sci U S A 108, 1272-1277
- Cantor JR, Stone EM, Chantranupong L, Georgiou G. (2009) The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity. Biochemistry 48, 11026-11031
- Varadarajan N, Cantor JR, Georgiou G, Iverson BL. (2009) Construction and flow cytometric screening of targeted enzyme libraries. Nat Protoc. 4, 893-901
- Camarero JA, Kimura RH, Woo YH, Shekhtman A, Cantor JR. (2007) Biosynthesis of a fully functional cyclotide inside living bacterial cells. Chembiochem 8, 1363-1366
- Finehout EJ, Cantor JR, Lee KH. (2005) Kinetic characterization of sequencing grade modified trypsin. Proteomics 5, 2319-2321
Preprints
2023
- Tharp KM, Park S, Timblin GA, Richards, AL, Berg, JA, Twells, NM, Riley, NM, Peltan, EL, Shon, DJ, Stevenson, E, Tsui K, Palomba, F, Lefebvre AEYT, Soens RW, Ayad NME, ten Hoeve-Scott J, Healy, K, Digman M, Dillin A, Bertozzi CR, Swaney DL, Mahal LK, Cantor JR, Paszek MJ, & Weaver VM. The microenvironment dictates glycocalyx construction and immune surveillance. bioRxiv.
https://doi.org/10.1101/2023.06.23.546317. - Flickinger, KM, Wilson, KM, Rossiter, NJ, Hunger, AL, Lee, TD, Hall, MD, & Cantor, JR. Conditional lethality profiling reveals anticancer mechanisms of action and drug-nutrient interactions. bioRxiv.
https://doi.org/10.1101/2023.06.04.543621
2021
- MacPherson S, Keyes S, Kilgour M, Smazynski J, Sudderth J, Turcotte T, Devlieger A, Yu J., Huggler KS, Cantor JR, DeBerardinis RJ, Siatskas C, Lum JJ. Clinically relevant T cell expansion protocols activate distinct metabolic programs and phenotypes. bioRxiv.
https://doi.org/10.1101/2021.08.24.457536.
2020
- Rossiter NJ, Huggler, KS, Adelmann CH, Keys HR, Soens RW, Sabatini DM* & Cantor, JR*. CRISPR screens in physiologic medium reveal conditionally essential genes in human cells. bioRxiv.
2020.08.31.275107; doi: https://doi.org/10.1101/2020.08.31.275107
*Co-corresponding
2019
- Leney-Greene, MA, Boddapati, AK, Su, HC, Cantor, JR* & Lenardo, MJ* Human plasma-like medium improves T lymphocyte activation. bioRxiv.
doi: https://doi.org/10.1101/740845
*Co-corresponding