2026
Kalvaityte-Repecke, M., Gabrilaviciute, S., Kvederaviciute, K., Burg, L., Bakunaite, E., Poss, K. D., and Balciunas, D. (2026). Epicardial Tcf21 facilitates cardiomyocyte dedifferentiation and heart regeneration in zebrafish. Developmental Biology S0012-1606(25)00335-5. DOI: 10.1016/j.ydbio.2025.12.004.
Brown, D. A., Koll, K. K., Brush, E. Darner, G., Curtis, T., Dvergsten, T., Tran, M., Milligan, C., Wolfson, D. W., Gonzales, T. J., Jeffs, S., Ehrardt, A., Bitolas, R., Landau, M., Reitz, K., Salven, D., Slota-Burtt, L., Snee, I., Singer-Freeman, E., Bhatia, S., Ou, J., Asokan, A., Currie, J. D., and Poss, K. D. (2026). Enhancer-directed gene delivery for digit regeneration based on conserved epidermal factors. Proceedings of the National Academy of Sciences, USA 123(17):e2532804123.
Shen, J., Jayadev, R., Ou, J., Rich, A., Ando, K., Di Talia, S., Sherwood, D. R., and Poss, K. D. (2026). Zebrafish lines enabling live visualization of extracellular matrix dynamics during development and regeneration. Development 153: dev.205402.
Rich, A., Li, Z., De Simone, A., Garcia, L., Janssen, J., Ando, K., Ou, J., Vergassola, M., Poss, K. D., and Di Talia, S. (2026) Decaying and expanding Erk gradients process memory of skeletal size during zebrafish fin regeneration. Nature Physics (in press) doi: 10.1038/s41567-026-03426.
Ando, K., Bangru, S., Welsby, J., Thompson, J. D., and Poss, K. D. (2026). Regeneration programs buffer genetic defects in animal development. PLOS Biology (in press)
Gillotay, P., Bangru, S., Shen, J., Moore, B., Ou, J., Stewart, R., and Poss, K.D. Microenvironmental and transcriptional determinants of the robustness of spinal cord regeneration in zebrafish. bioRxiv doi: https://doi.org/10.64898/2026.09.07.749713
2025
Ou, J. and Poss, K. D. (2025). geomeTriD: A R/Bioconductor package for interactive 3D plot of epigenetic data or single cell data . Bioinformatics Advances vbaf299. doi: 10.1093/bioadv/vbaf299.
Bangru S, Diegmiller R, Di Talia S, Poss KD. Signal control during tissue regeneration in adult animals . Nat Rev Mol Cell Biol . 2025 Nov 11. doi: 10.1038/s41580-025-00917-1. Online ahead of print. PMID: 41219473 Review.
Pronobis MI, DeLuca S, Lee S, Garcia L, Ou J, Bursac N, Poss KD. Ddx61-enriched condensates refine heart regeneration programs . Nat Commun . 2025 Oct 9;16(1):8992. doi: 10.1038/s41467-025-64026-5. PMID: 41068075
Wolfson DW, Hull JA, Li Y, Gonzalez TJ, Jayaram MD, Devlin GW, Cigliola V, Oonk KA, Rosales A, Bursac N, Asokan A, Poss KD. Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium . Elife . 2025 Sep 12;14:RP107148. doi: 10.7554/eLife.107148. PMID: 40938325
Butt FA, De Simone A, Di Talia S, Poss KD. In toto live imaging of Erk signaling dynamics in developing zebrafish hepatocytes. Dev Biol . 2025 Jul;523:43-50. doi: 10.1016/j.ydbio.2025.04.009. Epub 2025 Apr 12. PMID: 40228782
Ramkumar N, Richardson C, O’Brien M, Butt FA, Park J, Chao AT, Bagnat M, Poss KD, Di Talia S. Phased ERK responsiveness and developmental robustness regulate teleost skin morphogenesis . Proc Natl Acad Sci U S A. 2025 Mar 11;122(10):e2410430122. doi: 10.1073/pnas.2410430122. Epub 2025 Mar 5. PMID: 40042905; PMCID: PMC11912398.
2024
Poss, K. D. and Tanaka, E. M. (2024). Hallmarks of regeneration. Cell Stem Cell 31, 1244-1261.
Ando K, Ou J, Thompson JD, Welsby J, Bangru S, Shen J, Wei X, Diao Y, Poss KD. A screen for regeneration-associated silencer regulatory elements in zebrafish. Developmental Cell. 2024 Jan 25:S1534-5807(24)00004-2. doi: 10.1016/j.devcel.2024.01.004.
2023
Becker CJ, Cigliola V, Gillotay P, Rich A, De Simone A, Han Y, Di Talia S, Poss KD. In toto imaging of glial JNK signaling during larval zebrafish spinal cord regeneration. Development. 2023 Nov 24:dev.202076. doi: 10.1242/dev.202076. Epub ahead of print. PMID: 37997694.
Sun F, Poss KD. Inter-organ communication during tissue regeneration. Development. 2023 Dec 1;150(23):dev202166. doi: 10.1242/dev.202166. Epub 2023 Nov 27. PMID: 38010139.
Sun, F., De Simone, A., & Poss, K. D. (2023). Regeneration: Signaling superhighways . Current biology : CB , 33 (18), R947–R950. https://doi.org/10.1016/j.cub.2023.08.024
Cigliola V, Shoffner A, Lee N, Ou J, Gonzalez TJ, Hoque J, Becker CJ, Han Y, Shen G, Faw TD, Abd-El-Barr MM, Varghese S, Asokan A, Poss KD. Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer. Nat Commun. 2023 Aug 11;14(1):4857. doi: 10.1038/s41467-023-40486-5. PMID: 37567873; PMCID: PMC10421883.
Rao A, Lyu B, Jahan I, Lubertozzi A, Zhou G, Tedeschi F, Jankowsky E, Kang J, Carstens B, Poss KD, Baskin K, Goldman JA. The translation initiation factor homolog eif4e1c regulates cardiomyocyte metabolism and proliferation during heart regeneration. Development. 2023 Oct 15;150(20):dev201376. doi: 10.1242/dev.201376. Epub 2023 Jun 12. PMID: 37306388.
Zhou L, McAdow AR, Yamada H, Burris B, Klatt Shaw D, Oonk K, Poss KD, Mokalled MH. Progenitor-derived glia are required for spinal cord regeneration in zebrafish. Development. 2023 May 15; 150 (10):dev201162. doi: 10.1242/dev.201162. Epub 2023 May 22. PMID37213080
Yan R, Cigliola V, Oonk KA, Petrover Z, DeLuca S, Wolfson DW, Vekstein A, Mendiola MA, Devlin G, Bishawi M, Gemberling MP, Sinha T, Sargent MA, York AJ, Shakked A, DeBenedittis P, Wendell DC, Ou J, Kang J, Goldman JA, Baht GS, Karra R, Williams AR, Bowles DE, Asokan A, Tzahor E, Gersbach CA, Molkentin JD, Bursac N, Black BL, Poss KD. An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair. Cell Stem Cell. 2023 Jan 5;30(1):96-111.e6. doi: 10.1016/j.stem.2022.11.012. Epub 2022 Dec 13. PMID: 36516837; PMCID: PMC9830588.
2022
Haertter D, Wang X, Fogerson SM, Ramkumar N, Crawford JM, Poss KD, Di Talia S, Kiehart DP, Schmidt CF. Deep projection: Specific and robust projection of curved 2D tissue sheets from 3D microscopy using deep learning. Development. 2022 Sep 30:dev.200621. doi: 10.1242/dev.200621. PMID: 36178108
Osorio-Méndez, D., Miller, A., Begeman, I. J., Kurth, A., Hagle, R., Rolph, D., Dickson, A. L., Chen, C. H., Halloran, M., Poss, K. D., & Kang, J. (2022). Voltage-gated sodium channel scn8a is required for innervation and regeneration of amputated adult zebrafish fins. Proceedings of the National Academy of Sciences of the United States of America , 119 (28), e2200342119. https://doi.org/10.1073/pnas.2200342119
Sun J, Peterson EA, Wang AZ, Ou J, Smith KE, Poss KD, Wang J. hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration. Circulation. 2022 Jun 2:101161CIRCULATIONAHA121055468. doi: 10.1161/CIRCULATIONAHA.121.055468. Online ahead of print. PMID: 35652354
Das RN, Tevet Y, Safriel S, Han Y, Moshe N, Lambiase G, Bassi I, Nicenboim J, Brückner M, Hirsch D, Eilam-Altstadter R, Herzog W, Avraham R, Poss KD, Yaniv K. Generation of specialized blood vessels via lymphatic transdifferentiation. Nature. 2022 May 25. doi: 10.1038/s41586-022-04766-2. Online ahead of print. PMID: 35614218
Sun F, Ou J, Shoffner AR, Luan Y, Yang H, Song L, Safi A, Cao J, Yue F, Crawford GE, Poss KD. Enhancer selection dictates gene expression responses in remote organs during tissue regeneration. Nat Cell Biol. 2022 May;24(5):685-696. doi: 10.1038/s41556-022-00906-y. Epub 2022 May 5. PMID: 35513710; PMCID: PMC9107506.
Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration. Cao Y, Xia Y, Balowski JJ, Ou J, Song L, Safi A, Curtis T, Crawford GE, Poss KD, Cao J. Development. 2022 Feb 15;149(4):dev200133. doi: 0.1242/dev.200133. Epub 2022 Feb 18. PMID: 35179181Targeted Delivery for Cardiac Regeneration: Comparison of Intra-coronary Infusion and Intra-myocardial Injection in Porcine Hearts. Vekstein AM, Wendell DC, DeLuca S, Yan R, Chen Y, Bishawi M, Devlin GW, Asokan A, Poss KD, Bowles DE, Williams AR, Bursac N.Front Cardiovasc Med. 2022 Feb 10;9:833335. doi: 10.3389/fcvm.2022.833335. eCollection 2022.PMID: 35224061
2021
Transgenic mice for in vivo epigenome editing with CRISPR-based systems. Gemberling MP, Siklenka K, Rodriguez E, Tonn-Eisinger KR, Barrera A, Liu F, Kantor A, Li L, Cigliola V, Hazlett MF, Williams CA, Bartelt LC, Madigan VJ, Bodle JC, Daniels H, Rouse DC, Hilton IB, Asokan A, Ciofani M, Poss KD, Reddy TE, West AE, Gersbach CA. Nat Methods. 2021 Aug;18(8):965-974. doi: 10.1038/s41592-021-01207-2. Epub 2021 Aug 2. PMID: 34341582The RNA helicase Ddx52 functions as a growth switch in juvenile zebrafish. Tseng TL, Wang YT, Tsao CY, Ke YT, Lee YC, Hsu HJ, Poss KD, Chen CH. Development. 2021 Aug 1;148(15):dev199578. doi: 10.1242/dev.199578. Epub 2021 Jul 29. PMID: 34323273Mathematical modeling of Erk activity waves in regenerating zebrafish scales. Hayden LD, Poss KD, De Simone A, DiTalia S. Biophys J. 2021 May 19:S0006-3495(21)00418-5.doi: 10.1016/j.bpj.2021.05.04. Online ahead of print. PMID:34022234In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration. Pronobis MI, Zheng S, Goldman, JA, Poss, KD. Elife. 2021 Mar 25: 10:e66079. doin: 10.7554/eLife.66079. Online ahead of print. PMID: 33764296A new society for regenerative biologists. Poss KD, Tanaka EM. Development. 2021 Feb 12;148(3):dev199474. doi: 10.1242/dev.199474. PMID: 33579756 No abstract available.Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration. Peng X, Lai KS, She P, Kang J, Wang T, Li G, Zhou Y, Sun J, Jin D, Xu X, Liao L, Liu J, Lee E, Poss KD, Zhong TP. J Mol Cell Biol. 2020 Sep 16:mjaa046. doi: 10.1093/jmcb/mjaa046. Online ahead of print. PMID: 33582796Control of osteoblast regeneration by a train of Erk activity waves. DeSimone A, Evanitsky MN, Hayden L, Cox BD, Wang J, Tornini VA, Ou J, Chao A, Poss KD, Di Talia, S. Nature. 2021 Jan 6. doi: 10.1038/s41586-020-03085-8. Online ahead of printEnteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways. Ye L, Bae M, Cassilly CD, Jabba SV, Thorpe DW, Martin AM, Lu HY, Wang J, Thompson JD, Lickwar CR, Poss KD, Keating DJ, Jordt SE, Clardy J, Liddle RA, Rawls JF. Cell Host Microbe. 2020 Dec 16:S1931-3128(20)30633-8. doi: 10.1016/j.chom.2020.11.011. Online ahead of print. PMID: 33352109
2020
Ccn2a/Ctgfa is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish. Mukherjee D, Wagh G, Mokalled MH, Kontarakis Z, Dickson AL, Rayrikar A, Günther S, Poss KD, Stainier DYR, Patra C. Development. 2020 Nov 24:dev.193219. doi: 10.1242/dev.193219. Online ahead of print. PMID: 33234717Chen A, Han Y, Poss KD. Regulation of zebrafish fin regeneration by vitamin D signaling. Dev Dyn. 2020 Oct 16. doi: 10.1002/dvdy.261. Epub ahead of print. PMID: 33064344.
Ramkumar N, Sun F, Poss KD. Tissue Repair: A Tendon-see to Regenerate. Curr Biol . 2020;30(17):R1001-R1003. doi:10.1016/j.cub.2020.06.089.PMID: 32898487
Sun, F., Shoffner, A., and Poss, K. D. (2020). A genetic ablation model for the study of heart regeneration in zebrafish. Methods in Molecular Biology. 2021; 2158:71-80. doi: 10.1007/978-1-0716-068-1_7. PMID: 32857367
Shoffner, A., Cigliola, V., Lee, N., Ou, J., and Poss, K. D. (2020). Tp53 suppression promotes cardiomyocyte proliferation during zebrafish heart regeneration. Cell Reports . 2020 Sep 1;32(9):108089. doi: 10.1016/j.celrep.2020.108089. PMID: 32877671
Thompson JD, Ou J, Lee N, Shin K, Ciglola V, Song L, Crawford GE, Kang J, Poss KD. Identification and requirement of enhancers that direct gene expression during zebrafish fin regeneration. Development. 2020 July 14:dev.191262.doi:10.1242/dev.191262. PMID:32665240
Goldman JA, Poss KD. Gene Regulatory programmes of tissue regeneration. Nat Rev Genet. 2020 Jun 5. doi: 10.1038/s41576-020-0239-7. Online ahead of print.PMID: 32504079
Cigliola V, Becker CJ, Poss, KD, Building bridges, not walls: spinal cord regeneration zebrafish. Disease Models and Mechanisms . 2020 May 27;13(5):dmm0441331.doi: 10.1242/dmm.044131
Wang Z, Li Y, Hou B, Pronobis MI, Wang M, Wang Y, Cheng G, Weng W, Wang Y, Tang Y, Xu X, Pan R, Lin F, Wang N, Chen Z, Wang S, Ma LZ, Li Y, Huang D, Jiang L, Wang Z, Zeng W, Zhang Y, Du X, Lin Y, Li Z, Xia Q, Geng J, Dai H, Yu Y, Zhao XD, Yuan Z, Yan J, Nie Q, Zhang X, Wang K, Chen F, Zhang Q, Zhu Y, Zheng S, Poss KD, Tao SC, Meng X. An array of 60,000 antibodies for proteome-scale antibody generation and target discovery. Sci Adv . 2020 Mar 11;6(11):eaax2271. doi: 10.1126/sciadv.aax2271. eCollection 2020 Mar.
Pronobis M, Poss KD. Signals for cardiomyocyte proliferation during zebrafish heart regeneration. Current Opinion in Physiology 14 (2020):78-85
2019
Honkoop H, de Bakker DE, Aharonov A, Kruse F, Shakked A, Nguyen PD, de Heus C, Garric L, Muraro MJ, Shoffner A, Tessadori F, Peterson JC, Noort W, Bertozzi A, Weidinger G, Posthuma G, Grun D, van der Laarse WJ, Klumperman J, Jaspers RT, Poss KD, van Oudenaarden A, Tzahor E, Bakkers J. Single-cell analysis uncovers that metabolic reprogramming by ErbBw signaling is essential for cardiomyocyte proliferation in the regenerating heart. Elife. 2019 Dec 23;8. pii: e50163. doi: 10.7554/eLife.50163.
Marín-Juez R, El-Sammak H, Helker CSM, Kamezaki A, Mullapuli ST, Bibli SI, Foglia MJ, Fleming I, Poss KD, Stainier DYR. Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation. Dev Cell. 2019 Nov 18;51(4):503-515.e4. doi: 10.1016/j.devcel.2019.10.019
Wang, YT, Tseng TL, Kuo YC, Yu JK, Su YH, Poss KD, Chen CH. Genetic Reprogramming of Positional Memory in a Regenerating Appendage. Current Biology. 2019 Nov 22. pii: s0960-9822(19)31378-8. doi: 10.1016/j.cub.2019.10.038
Gancz D, Raftrey BC, Perlmoter G, Marin-Juez R, Semo J, Matsuoka RL, Karra R, Raviv H, Moshe N, Addadi Y, Golani O, Poss KD, Red-Horse K, Stainier D, Yaniv K. Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration. Elife. 2019 Nov 8; 8 pii:e44153.doi:10.7554
Cox BD, Yun MH, Poss KD. Can laboratory model systems instruct human limb regeneration? Development. 2019 Oct 2;146(20). doi:10.1242/dev.181016
Han Y, Chen A, Umansky K-B, Oonk KA, Choi W-Y, Dickson AL, Ou J, Cigliola V, Yifa O, Cao J, Tornini VA, Cox BD, Tzahor E, Poss KD. Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish. Developmental Cell (2019), https://doi.org/10.1016/j.devcel.2019.01.001
2018
Cox BD, De Simone A, Tornini VA, Singh SP, Di Talia S, Poss KD. In Toto Imaging of Dynamic Osteoblast Behaviors in Regenerating Skeletal Bone. Curr Biol. 2018 Dec 17;28(24):3937-3947.
Mokalled MH, Poss KD. A Regeneration Toolkit. Dev Cell. 47 (3):276-280.
Walton EM, Cronan MR, Cambier CJ, Rossi A, Marass M, Foglia MD, Brewer WJ, Poss KD, Stainier DYR, Bertozzi CR, Tobin DM. Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling. Cell Hose Microbe. 24(4):514-525.
Karra R, Foglia MJ, Choi WY, Belliveau C, DeBenedittis P, and Poss KD. Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish. PNAS 115(35):8805-8810.
Cao J and Poss KD. The epicardium as a hub for heart regeneration. Nature Reviews: Cardiology epublished 27 June 2018.
Wopat S, Bagwell J, Sumigray KD, Dickson AL, Huitema LFA, Poss KD, Schulte-Merker S, and Bagnat M. Spine Patterning Is Guided by Segmentation of the Notochord Sheath. Cell Rep 22(8):2026-2038.
2017
Yang XH, Nadadur RD, Hilvering CR, Bianchi V, Werner M, Mazurek SR, Gadek M, Shen KM, Goldman JA, Tyan L, Bekeny J, Hall JM, Lee N, Perez-Cervantes C, Burnicka-Turek O, Poss KD, Weber CR, de Laat W, Ruthenburg AJ, and Moskowitz IP. Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm. Elife 6. pii: e31683.
Cao J, Wang J, Jackman CP, Cox AH, Trembley MA, Balowski JJ, Cox BD, De Simone A, Dickson AL, Di Talia S, Small EM, Kiehart DP, Bursac N, and Poss KD. Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue. Dev Cell. 2017 Sep 25;42(6):600-615.e4
Chen CH and Poss KD. Regeneration Genetics. Annu Rev Genet.
Tornini VA, Thompson JD, Allen RL, and Poss KD. Live fate-mapping of joint-associated fibroblasts visualizes expansion of cell contributions during zebrafish fin regeneration. Development 144(16):2889-2895.
Tzahor E and Poss KD. Cardiac regeneration strategies: Staying young at heart. Science 356(6342):1035-1039.
Goldman JA, Kuzu G, Lee N, Karasik J, Gemberling M, Foglia MJ, Karra R, Dickson AL, Sun F, Tolstorukov MY, and Poss KD. Resolving Heart Regeneration by Replacement Histone Profiling. Dev Cell 40(4):392-404.e5.
Karra R and Poss KD. Redirecting cardiac growth mechanisms for therapeutic regeneration. J Clin Invest 127(2):427-436.
2016
Cao J, Navis A, Cox BD, Dickson AL, Gemberling M, Karra R, Bagnat M, and Poss KD. Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration. Development 143, 232-243.
Foglia MJ and Poss KD. Building and re-building the heart by cardiomyocyte proliferation. Development 143(5):729-40.
Foglia MJ, Cao J, Tornini VA, and Poss KD. Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium. Development pii: dev.136606.
Chen CH, Puliafito A, Cox BD, Primo L, Fang Y, Di Talia S, and Poss KD. Multicolor Cell Barcoding Technology for Long-Term Surveillance of Epithelial Regeneration in Zebrafish. Dev Cell 36(6):668-80.
Kang J, Hu J, Karra R, Dickson AL, Tornini VA, Nachtrab G, Gemberling M, Goldman JA, Black BL, and Poss KD. Modulation of tissue repair by regeneration enhancer elements. Nature 532(7598):201-6.
Cao J and Poss KD. Explant culture of adult zebrafish hearts for epicardial regeneration studies. Nat Protoc 11(5):872-81.
Han Y and Poss KD. Accessories to Limb Regeneration. Dev Cell 23;37(4):297-8.
Nichols JT, Blanco-Sánchez B, Brooks EP, Parthasarathy R, Dowd J, Subramanian A, Nachtrab G, Poss KD, Schilling TF, and Kimmel CB. Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca. Development dev.141036.
Tornini VA, Puliafito A, Slota LA, Thompson JD, Nachtrab G, Kaushik AL, Kapsimali M, Primo L, Di Talia S, and Poss KD. Live Monitoring of Blastemal Cell Contributions during Appendage Regeneration. Curr Biol S0960-9822(16)31017-X.
Di Talia S and Poss KD. Monitoring Tissue Regeneration at Single-Cell Resolution. Cell Stem Cell 19(4):428-431.
Mokalled MH, Patra C, Dickson AL, Endo T, Stainier DY, and Poss KD. Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish. Science 354(6312):630-634.
Wang J and Poss KD. Methodologies for Inducing Cardiac Injury and Assaying Regeneration in Adult Zebrafish. Dev Cell 37(4):297-8.
2015
Gemberling M, Karra R, Dickson AL, and Poss KD. Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish. eLife 4, e05871.
Wang J, Cao J, Dickson AL, and Poss KD. Epicardial regeneration is guided by cardiac outflow tract and Hh signaling. Nature 522, 226-230.
Palencia-Desai S, Rost MS, Schumacher JA, Ton QV, Craig MP, Baltrunaite K, Koenig A, Wang J, Poss KD, Chi NC, Stainier DYR, and Sumanas S. Myocardium and BMP signaling are required for endocardial differentiation. Development 142, 2304-2315,
Nagelberg D, Wang J, Su R, Torres-Vazquez J, Poss KD, and Knaut H. Origin, specification, and plasticity of the great vessels of the heart. Current Biology 17, 2099-2110.
Mahmoud AI, O’Meara CC, Gemberling MG, Zhao L, Bryant DM, Zheng R, Gannon JB, Cai L, Choi W-Y, Egnaczyk GF, Burns CE, Burns CG, MacRae CA, Poss KD, and Lee RT. Nerves regulate cardiomyocyte proliferation and heart regeneration. Developmental Cell 34, 387-399.
Chen CH, Merriman AF, Savage J, Willer J, Wahlig T, Katsanis N, Yin VP, and Poss KD. Transient laminin beta 1a induction defines the wound epidermis during zebrafish fin regeneration. PLoS Genetics 11, e1005437.
Karra R, Knecht A, Kikuchi K, and Poss KD. Myocardial NF-kB induction is essential for zebrafish heart regeneration. Proceedings of the National Academy of Sciences, USA 112, 13255-13260.
Kang J, Karra R, and Poss KD. Back in black. Developmental Cell 33, 623-624.
2014
2013
Choi W-Y, Gemberling M, Wang J, Holdway JE, Shen MS, Karlstrom RO, and Poss KD. In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. Development 140, 660-666.
Guner-Ataman B, Paffett-Lugassy N, Adams MS, Nevis KR, Obregon P, Kikuchi K, Poss KD, Burns CE, and Burns CG. Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function. Development 140, 1364-1368.
Le X, Pugach EK, Hettmer S, Storer NY, Liu J, Wills AA, Poss KD, Wagers AJ, Langenau DM, and Zon LI. Dual inhibition of S6-kinase and MAPK pathways suppresses RAS-induced rhabdomyosarcoma in zebrafish. Development 140, 2354-2364.
Gupta V, Gemberling M, Karra R, Rosenfeld G, Evans T, and Poss KD. An injury-responsive Gata4 program shapes the zebrafish cardiac ventricle. Current Biology 23, 1221-1227.
Johnson AN, Mokalled MH, Valera JM, Poss KD, and Olson EN. A conserved RNA processing pathway coordinates striated muscle development. Development 140, 3645-3656.
Fang Y, Gupta V, Karra R, Holdway JE, Kikuchi K, and Poss KD. Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. Proceedings of the National Academy of Sciences, USA 110, 13416-13421.
Nachtrab G, Kikuchi K, Tornini V, and Poss KD. Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. Development 140, 3754-3764.
Kang J, Nachtrab G, and Poss KD. Local Dkk1 crosstalk from breeding ornaments impedes regeneration of injured male zebrafish fins. Developmental Cell 27, 19-31.
Wang J, Karra R, Dickson AL, and Poss KD. Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration. Developmental Biology 382, 427-435.
Chen CH, Durand E, Wang J, Zon LI, and Poss KD. zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish. Development 140, 4988-4997.
Gemberling M, Bailey TJ, Hyde DR, and Poss KD. The zebrafish as a model for complex tissue regeneration. Trends in Genetics 29, 611-620.
2012
Yin VP, Lepilina A, Smith A, and Poss KD. Regulation of zebrafish heart regeneration by miR-133. Developmental Biology 365, 319-327.
Singh SP, Holdway JE, and Poss KD. Regeneration of amputated zebrafish fin rays by de novo osteoblasts. Developmental Cell 22, 879-886.
Gupta V and Poss KD. Clonally dominant cardiomyocytes direct heart morphogenesis. Nature 484, 479-484.
Major RJ and Poss KD. Zebrafish heart regeneration. In “Heart regeneration: stem cells and beyond” , edited by F. Engel, (World Scientific Publishing Co., Pte. Ltd.)
Choi W-Y and Poss KD. Cardiac regeneration. Current Topics in Developmental Biology 100, 319-344.
Kikuchi K and Poss KD. Cardiac regenerative capacity and mechanisms. Annual Review of Cell and Developmental Biology 28, 719-741.
Nachtrab G and Poss KD. Toward a blueprint for regeneration. Development 139, 2639-2642.
2011
Shin D, Lee Y, Poss KD, and Stainier DYR. Restriction of hepatic competence by Fgf signaling. Development 138, 1339-1348.
Kikuchi K, Holdway JE, Major RJ, Blum N, Dahn RD, Begemann G, and Poss KD. Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. Developmental Cell 20, 397-404.
Kikuchi K, Gupta V, Wang J, Holdway JE, Wills AA, Fang Y, and Poss KD. tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. Development 138, 2895-2902.
Wang J, Panáková D, Kikuchi K, Holdway JE, Gemberling M, Burris JS, Singh SP, Dickson AL, Lin YF, Sabeh MK, Werdich AA, Yelon D, MacRae CA, and Poss KD. The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Development 138, 3421-3430.
Qin Z, Kidd AR, Thomas JL, Poss KD, Hyde DR, Raymond PR, and Thummel R. Fgf signaling is required for zebrafish rod photoreceptor cell maintenance and regeneration. Experimental Eye Research 93, 726-734.
Nachtrab G, Czerwinski M, and Poss KD. Sexually dimorphic fin regeneration in zebrafish controlled by androgen/GSK3 signaling. Current Biology 21, 1912-1917.
2010
Gonzalez-Quevedo R, Lee Y, Poss KD, and Wilkinson DG. Neuronal regulation of the spatial patterning of neurogenesis. Developmental Cell 18, 136-147.
Kikuchi K, Holdway JE, Werdich AA, Anderson RM, Fang Y, Egnaczyk GF, Evans T, MacRae CA, Stainier DYR, and Poss KD. Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes. Nature 464, 601-605.
Lee Y, Nachtrab G, Klinsawat PW, Hami D, and Poss KD. Ras controls melanocyte expansion during zebrafish fin stripe regeneration. Disease Models and Mechanisms 3, 496-503.
Yin C, Kikuchi K, Hochgreb T, Poss KD, and Stainier DYR. Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish. Developmental Cell 18, 973-984.
Liu J, Bressan M, Hassel D, Huisken J, Staudt D, Kikuchi K, Poss KD, Mikawa T, and Stainier DYR. A dual role for ErbB2 signaling in cardiac trabeculation. Development 137, 3867-3875.
Poss KD. Cardiac regeneration in the zebrafish model system. In “Heart Development and Regeneration”, edited by R. P. Harvey and N. Rosenthal, (Elsevier, Inc.)
Poss KD. Advances in understanding tissue regenerative capacity and mechanisms in animals. Nature Reviews Genetics 11, 710-722.
2009
2008
Wills AA, Holdway JE, Major RJ, and Poss KD. Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish. Development 135, 183-192.
Yin V, Thompson JM, Thummel R, Hyde D, Hammond S, and Poss KD. (2008). Fgf-dependent depletion of microRNA-133 promotes zebrafish appendage regeneration. Genes and Development 22, 728-733.
Wills AA, Kidd AR, Lepilina A, and Poss KD. Fgfs control homeostatic regeneration in adult zebrafish fins. Development 135, 3063-3070.
Marques S, Lee Y, Poss KD, and Yelon D. Reiterative roles for Fgf signaling in the establishment of size and proportion of the zebrafish heart. Developmental Biology 321, 397-406.
Waxman JS, Keegan BR, Roberts RW, Poss KD, and Yelon D. Hox5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish. Developmental Cell 15, 923-934.
Yin VP and Poss KD. New regulators of vertebrate appendage regeneration. Current Opinion in Genetics and Development 18, 381-386.
2007
Nechiporuk A, Linbo T, Poss KD, and Raible DW. Specification of epibranchial placodes in zebrafish. Development 134, 611-623.
Shin D, Shin CH, Tucker J, Ober E, Rentzsch F, Poss KD, Hammerschmidt M, Mullins MC, and Stainier DYR. Bmp and Fgf signaling are essential for liver specification in zebrafish. Development 134, 2041-2050.
Poss KD. Getting to the heart of regeneration in zebrafish. Seminars in Cell and Developmental Biology 18, 36-45.
Major RJ and Poss KD. Zebrafish heart regeneration as a model for cardiac tissue repair. Drug Discovery Today: Disease Models 4, 219-225.
2006
2005
2004
2003
Nechiporuk A, Poss KD, Johnson SL, and Keating MT. Positional cloning of a temperature-sensitive mutant emmental reveals a role for Sly1 during cell proliferation in zebrafish fin regeneration. Developmental Biology 258, 291-306.
Gillette-Ferguson I, Ferguson DG, Poss KD, and Moorman SJ. Changes in gravitational force induce alterations in gene expression that can be monitored in the live, developing zebrafish heart. Advances in Space Research 32, 1641-1646.
Traver D, Paw BH, Poss KD, Penberthy WT, Lin S, and Zon LI. Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. Nature Immunology 4, 1238-1246.
Poss KD, Keating MT, and Nechiporuk A. Tales of regeneration in zebrafish. Developmental Dynamics 226, 202-210.
2002