via UW Health
Melissa Skala’s technology harnesses the natural light produced by cells in order to track response to cancer drug treatment.
Meet new Morgridge biomedical imaging Investigator Juan Caicedo, who specializes in machine learning to decode complex patterns in human biology.
A study on metabolic reprogramming in cancer and immune cells is helping scientists better understand the cell interactions surrounding cancer progression — a key to developing more effective and personalized treatments.
Scientists use stem cells to develop CAR macrophages that can infiltrate and kill tumor cells, showing promise for cancer immunotherapy treatments.
Every cell has about 20,000 proteins, several hundred metabolites, and couple of thousand lipids. When those things get perturbed, bad things can happen. But measuring those changes may offer essential clues for fighting cancer.
At a meeting of the Wisconsin Tech Council, Morgridge scientists described the renaissance taking place in metabolism research, which is revealing newfound connections to disease and entirely new roads to treatment and prevention.
After years of building tools for bioinformatics research, Morgridge Postdoctoral Fellow Matt Bernstein takes his skills to industrial cancer research.
An advanced biomedical imaging technique reveals how cancer cells can hijack the metabolic activity of certain non-cancer cells in the pancreas to fuel tumor growth.
Morgridge Postdoctoral Fellow Matthew Bernstein developed a web tool to explore public RNAseq datasets to facilitate analysis for cancer researchers.
Morgridge investigator Jason Cantor is partnering with Thermo Fisher Scientific to give biologists a new medium to study human cells in their most natural state.
Neuroendocrine cancers grow so slowly they often evade detection before it’s too late. By mimicking that slow growth in the lab, the Melissa Skala Lab hopes to speed up the creation of more effective treatments.
Scientists have developed a nondestructive way of measuring drug treatment responses in lab-grown cancer samples.
Researchers publish findings on use of a more human-like cell culture medium to explore gene essentiality
The Jason Cantor Lab at Morgridge is utilizing a new cell culture medium to ask how critical genes are to the survival and reproduction of human cells under different growth conditions. The technique could have important ramifications for the treatment of human diseases.
Researchers at the Morgridge Institute and UW–Madison want to ensure that pancreatic cancer treatment options are accessible to all — regardless of race, ethnicity, or insurance status — so that patients can make the most informed decisions regarding their care.
A Morgridge imaging study of macrophages — immune cells that are important to human health, but paradoxically can help some cancers grow and spread — is offering better ways to understand these cells and target them with immunotherapies.
‘Like a Map of the City’ – How Metabolic Networks Contribute to Our Understanding of Cancer’s Growth
via UW Health
When Morgridge investigator Jing Fan thinks about metabolism, she is focused on the complicated network of biochemical reactions. Her lab has been working on understanding metabolism in a quantitative, systematic way.
A new imaging method developed by the Skala lab uses the natural autofluorescence within cells to assess T cell activity. The technique could help assess T cell involvement in immunotherapies.
Imagine your chances of developing an invasive cancer were the same as a coin toss. Do you opt for aggressive treatments like surgery and chemotherapy, or do you take your chances that the cancer will never manifest?
Alexandra Walsh, an assistant scientist in the lab of Morgridge medical engineer Melissa Skala, is leading a project to use non-invasive fluorescence imaging to identify and sort T cells for use in cancer immunotherapy treatments. The technology won a 2018 Innovation Award from the Wisconsin Alumni Research Foundation.
Melissa Skala and Paul Campagnola, a professor of biomedical engineering at UW–Madison, hope to make inroads toward improved drug therapies through a two-year National Institutes of Health Exploratory/Developmental Research Grant.
Melissa Skala, a Morgridge Institute for Research investigator in medical engineering, won a highly competitive award from the nonprofit organization Stand Up to Cancer at its annual 2017 summit January in Santa Monica.
Oncologists are struggling to improve the grim survival rates of pancreatic cancer, which are especially frustrating in an era that is making good progress on other cancer fronts. “I think
Skala’s research problems focus on cancer detection and treatment, and her expertise in light-based, optical imaging is giving clinicians revolutionary new tools for the fight. Skala will be bringing her talents this summer from Vanderbilt University to the Morgridge Institute for Research and the University of Wisconsin–Madison, as a Morgridge investigator and professor of Biomedical Engineering (BME).
Scientists know that the hormone estrogen is a major driver in the growth of cervical cancer, but a new study examining genetic profiles of 128 clinical cases reached a surprising conclusion: Estrogen receptors all but vanish in cervical cancer tumors.
The tools of modern biology have made it possible to obtain an incredibly detailed picture of how cancer cells differ from healthy cells at the molecular level. Somewhat paradoxically, despite these meticulous portraits of cancer, it remains remarkably difficult to answer the very fundamental question: What caused cancer in this patient?