The Cantor lab is jointly affiliated with the Metabolism Theme at the Morgridge Institute for Research and the Departments of Biochemistry and Biomedical Engineering at the University of Wisconsin-Madison.

Our lab has broad interests in modeling, understanding, and exploiting the impact of environmental factors on human cell metabolism, with a particular focus on hematological cancers and normal lymphocytes. We use an interdisciplinary approach to discover unforeseen biological (and pharmacological) phenomena in cell metabolism, cancer biology, and immunology that may have been overlooked or misinterpreted owing to the use of conventional in vitro (and perhaps even in vivo) model systems that poorly mimic physiologic conditions. Ultimately, we aim to translate our findings into new therapeutic opportunities.

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Principal Investigator Jason Cantor

Jason earned his B.S. in Chemical Engineering (2004) magna cum laude from Cornell University, and then completed his Ph.D. in Chemical Engineering (2010) from the University of Texas at Austin. Under the guidance of George Georgiou, Jason’s doctoral research focused on the development of new strategies to engineer therapeutic enzymes with reduced immunogenicity for cancer therapy, and was supported, in part, through a graduate fellowship awarded by the U.S. Department of Homeland Security. Jason then carried out his postdoctoral research in the laboratory of David M. Sabatini at the Whitehead Institute for Biomedical Research (MIT). There, he focused on designing new tools to better understand how environmental factors influence the metabolic regulation of cancer cells. His postdoctoral research was funded, in part, through fellowships awarded by both the American Cancer Society and the Koch Institute for Integrative Cancer Research at MIT, and was also later recognized with a Margaret and Herman Sokol Postdoctoral Award from the Whitehead Institute. In August 2018, Jason became a Metabolism Investigator at the Morgridge Institute for Research and an Assistant Professor in the Departments of Biochemistry and Biomedical Engineering at the University of Wisconsin-Madison.

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