Metabolism

Cantor Lab

The Cantor Lab studies cellular metabolism and how it is influenced by environmental factors with relevance to cancer and immunology

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The Cantor lab is jointly affiliated with the Morgridge Institute for Research and the Department of Biochemistry at the University of Wisconsin-Madison. 

Our overarching hypothesis is that existing model systems have masked important insights into fundamental cell physiology and drug development. To test this with a specific focus on hematological cancers and normal immune cells, we apply a highly multidisciplinary approach that combines principles of biology and engineering across several distinct projects. Our primary goal is apply innovative tools and concepts to understand how environmental factors influence both basic cell physiology and drug activity. By achieving this broad objective, our group hopes to: (I) uncover new targetable vulnerabilities in human cancers; and (II) leverage our findings to propose new cancer treatment strategies that incorporate either the direct modulation of environmental factors or the use of immunotherapies with improved efficacy.

We are actively recruiting team members. Learn more >

Principal Investigator Jason Cantor

Jason earned his B.S. in Chemical Engineering (2004) magna cum laude from Cornell University, and then completed his Ph.D. in Chemical Engineering (2010) from the University of Texas at Austin. Under the guidance of George Georgiou, Jason’s doctoral research focused on the development of new strategies to engineer therapeutic enzymes with reduced immunogenicity for cancer therapy, and was supported, in part, through a graduate fellowship awarded by the U.S. Department of Homeland Security. Jason then carried out his postdoctoral research in the laboratory of David M. Sabatini at the Whitehead Institute for Biomedical Research (MIT). There, he focused on designing new tools to better understand how environmental factors influence the metabolic regulation of cancer cells. His postdoctoral research was funded, in part, through fellowships awarded by both the American Cancer Society and the Koch Institute for Integrative Cancer Research at MIT, and was also later recognized with a Margaret and Herman Sokol Postdoctoral Award from the Whitehead Institute. In August 2018, Jason became a Metabolism Investigator at the Morgridge Institute for Research and an Assistant Professor in the Departments of Biochemistry and Biomedical Engineering at the University of Wisconsin-Madison.

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