Scientists use stem cells to develop CAR macrophages that can infiltrate and kill tumor cells, showing promise for cancer immunotherapy treatments.
Classrooms from Wisconsin and beyond explore Morgridge science through new Meet the Lab resources from PBS Wisconsin.
Former Morgridge Postdoctoral Fellow Finn Kuusisto was awarded for his work developing information technology to improve virtual reality applications that could one day be applied to biomedical devices.
A science trailblazer retires: Stem cell researcher James Thomson’s legacy changed the future of biology
James Thomson helped the scientific world turn its attention to the remarkable stem cells that give rise to all of the building blocks of life. After more than 30 years with UW–Madison and 15 years with the Morgridge Institute, Thomson has announced plans to retire in July 2022.
Thomson Lab alumna Shannon Strader returned to her roots at Morgridge to participate in an upcoming outreach feature with PBS Wisconsin Meet the Lab.
Stem cell pioneer James Thomson is leading a potentially transformational project to develop a safe and functional cell-based artificial artery that could be pulled from medical inventories and used by vascular surgeons.
A few of our Morgridge alumni shared thoughts on their research experience at the Morgridge Institute, their plans moving forward and their warm shoutouts to some of the people who helped them along the way.
Congratulations to the graduating students and research staff as they move onward and upward. A few of these students and staff shared about their time at the Morgridge Institute, their accomplishments and their plans for what’s next.
A Morgridge regenerative biology team has created a first-ever human model for developmental timing: A “clock in a dish” that will help explore mysteries of early human development.
Scientists at the Morgridge Institute are working toward a dream of creating artery banks with readily-available material to replace diseased arteries during surgery. Recent work highlights highlights a better way to grow smooth muscle cells, putting the science one step closer to that goal.
Together with the University of Wisconsin–Madison, we look back on 20 years of stem cell research and see where we’re going next. Catch up on what’s happened since James Thomson’s prescient prediction that stem cells “will change medicine, period.”
Just as blood banks are essential to medicine, the Thomson Lab hopes to see the advent of artery banks that give surgeons a better, readily available material to replace diseased arteries. The lab is using pluripotent stem cells to grow the cellular building blocks of the artery — endothelial and smooth muscle cells — and coax them into assembling into arteries that can grow and thrive in a majority of patients.
James Thomson, the UW–Madison biologist whose stem cell discovery 20 years ago opened fascinating and promising new avenues in science, took time to discuss his thoughts on the breakthrough and what the future holds for the field of regenerative medicine.
While refining ways to grow arterial endothelial cells in the lab, a regenerative biology team at the Morgridge Institute for Research unexpectedly unearthed a powerful new model for studying a hallmark of vascular disease.
New techniques developed at the Morgridge Institute for Research and the University of Wisconsin–Madison have produced, for the first time, functional arterial cells at both the quality and scale to be relevant for disease modeling and clinical application.
The prospect of creating artery “banks” available for cardiovascular surgery, bypassing the need to harvest vessels from the patient, could transform treatment of many common heart and vascular ailments.
Wisconsin biotechnology advocacy organization BioForward honored two giants in state biomedical innovation — stem cell research pioneer James Thomson and entrepreneur Ralph Kauten — for their scientific and business achievement during its annual summit September 27 in Madison.
A new system developed by scientists at the Morgridge Institute for Research and the University of Wisconsin–Madison may provide a faster, cheaper and more biologically relevant way to screen drugs and chemicals that could harm the developing brain.
Thomson’s discoveries in human stem cell research at UW–Madison have redefined biomedicine, first with the isolation and culturing of human embryonic stem cells in 1998; then in the development of human pluripotent stem cells from adult skin cells in 2007.
A team of engineers at the University of Wisconsin–Madison has created a process to improve the creation of synthetic neural stem cells for use in central nervous system research.
With a $2.2 million grant from the National Institutes of Health, stem cell pioneer Dr. James Thomson, University of Wisconsin–Madison associate professor of biomedical engineering William Murphy and School of Medicine and Public Health medical informatics professor David Page will lead a team to derive and assemble the distinct cell types found in the human cerebral cortex.
Scientists from the Morgridge Institute for Research, the University of Wisconsin–Madison, the University of California and the WiCell Research Institute moved gene therapy one step closer to clinical reality by determining that the process of correcting a genetic defect does not substantially increase the number of potentially cancer-causing mutations in induced pluripotent stem cells.
A team of scientists from the Morgridge Institute for Research at the University of Wisconsin–Madison reports that it has created induced human pluripotent stem (iPS) cells completely free of viral vectors and exotic genes.
The Morgridge Institute for Research, the private, not-for-profit side of the Wisconsin Institutes for Discovery, is announcing the appointment of world-renowned stem cell pioneer and researcher James Thomson as the first member of its multidisciplinary scientific leadership team.