Publications

2019

• Cellular Metabolic Heterogeneity In Vivo Is Recapitulated in Tumor Organoids. Sharick JT, Jeffery JJ. Karim MR, Walsh CM, Esbona K, Cook RS, Skala MC. Neoplasia 21:6, June 2019, Pg 615-626. doi: 10.1016/j.neo.2019.04.004
• Imaging intratumoral metabolic heterogeneity. Walsh AJ, Sharick JT, Skala MC. Nature BME: News & Views. 3, 333–334 (2019).
• Redox imaging and optical coherence tomography of the respiratory ciliated epithelium. Gil DA, Sharick JT, Mancha S, Gamm UA, Choma MA, Skala MC. J Biomed Opt. 2019 Jan 30. doi: 10.1117/1.JBO.24.1.010501.

2018

• Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines. Capowski EE, Samimi K, Mayerl SJ, Phillips MJ, Pinilla I, Howden SE, Saha J, Jansen AD, Edwards KL, Jager LD, Barlow K, Valiauga R, Erlichman Z, Hagstrom A, Sinha D, Sluch VM, Chamling X, Zack DJ, Skala MC, Gamm DM. Development. 2018 Dec 19. doi: 10.1242/dev.171686.
• Quantitative Label-Free Imaging of 3D Vascular Networks Self-Assembled in Synthetic Hydrogels. Kaushik G, Gil DA, Torr E, Berge ES, Soref C, Uhl P, Fontana G, Antosiewicz-Bourget J, Edington C, Schwartz MP, Griffith LG, Thomson JA, Skala MC, Daly WT, Murphy WL. Adv Healthc Mater. 2018 Dec 19 doi: 10.1002/adhm.201801186.
• Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model. Ayuso JM, Truttschel R, Gong MM, Humayun M, Virumbrales-Munoz M, Vitek R, Felder M, Gillies SD, Sondel P, Wisinski KB, Patankar M, Beebe DJ, Skala MC. OncoImmunology (2018) DOI: 10.1080/2162402X.2018.1553477
• Imaging retinal melanin: a review of current technologies. Lapierre-Landry M, Carroll J, Skala MC. J Biol Eng. (2018) Dec 4;12:29. doi: 10.1186/s13036-018-0124-5.
• MTORC1/2 inhibition as a therapeutic strategy for PIK3CA mutant cancers. Fricke SL, Payne SN, Favreau PF, Kratz JD, Pasch CA, Foley TM, Yueh AE, Van De Hey DR, Depke MG, Korkos DP, Sha GC, DeStefanis RA, Clipson L, Burkard ME, Lemmon KK, Parsons BM, Kenny PA, Matkowskyj KA, Newton MA, Skala MC, Deming DA. Mol Cancer Ther. (2018) Nov 13. doi: 10.1158/1535-7163.MCT-18-0510.
• BET inhibitors reduce cell size and induce reversible cell cycle arrest in AML. Zhang S, Zhao Y, Heaster TM, Fischer MA, Stengel KR, Zhou X, Ramsey H, Zhou MM, Savona MR, Skala MC, Hiebert SW. J Cell Biochem. (2018) Nov 11. doi: 10.1002/jcb.28005.
• Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations. Ayuso JM, Gillette A, Lugo-Cintrón K, Acevedo-Acevedod S, Gomez I, Morgan M, Heaster T, Wisinski KB, Palecek SP, Skala MC, Beebe DJ. EBioMedicine (2018) doi: 10.1016/j.ebiom.2018.10.046
• Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography. Lapierre-Landry M, Huckenpahler AL, Link BA, Collery RF, Carroll J, Skala MC. Transl Vis Sci Technol. 2018 Sep 4;7(5):4. doi: 10.1167/tvst.7.5.4.
• Photothermal optical coherence tomography of indocyanine green in ex vivo eyes. Lapierre-Landry M, Connor TB, Carroll J, Tao YK, Skala MC. Opt Lett. 2018 Vol. 43, Issue 11, pp. 2470-2473. doi: 10.1364/OL.43.002470.
• Protein-bound NAD(P)H Lifetime is Sensitive to Multiple Fates of Glucose Carbon. Sharick JT, Favreau PF, Gillette AA, Sdao SM, Merrins MJ, Skala MC. Scientific Reports (2018) Vol. 8, Article number: 5456. doi:10.1038/s41598-018-23691-x
• Quantifying optical properties with visible and near-infrared optical coherence tomography to visualize esophageal microwave ablation zones. Niemeier RC, Etoz S, Gil DA, Skala MC, Brace CL, and Rogers JD. Biomed. Opt. Express. 2018 9(4) 1648-1663. doi: 10.1364/BOE.9.001648
• Oxidative stress via inhibition of the mitochondrial electron transport and Nrf-2-mediated anti-oxidative response regulate the cytotoxic activity of plumbagin. Kapur A, Beres T, Rathi K, Nayak AP, Czarnecki A, Felder M, Gillette A, Ericksen SS, Sampene E, Skala MC, Barroilhet L, Patankar MS. Sci Rep. 2018 Jan 18;8(1):1073. doi: 10.1038/s41598-018-19261-w.
• Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells. Zhang Q, Jeppesen DK, Higginbotham JN, Demory Beckler M, Poulin EJ, Walsh AJ, Skala MC, McKinley ET, Manning HC, Hight MR, Schulte ML, Watt KR, Ayers GD, Wolf MM, Andrejeva G, Rathmell JC, Franklin JL, Coffey RJ. Cell Mol Gastroenterol Hepatol. 2018 Jan 31;5(4):627-629.e6. doi: 10.1016/j.jcmgh.2018.01.013
• Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Schulte ML, Fu A, Zhao P, Li J, Geng L, Smith ST, Kondo J, Coffey RJ, Johnson MO, Rathmell JC, Sharick JT, Skala MC, Smith JA, Berlin J, Washington MK, Nickels ML, Manning HC. Nat Med. 2018 Jan 15. doi: 10.1038/nm.4464.

2017

• Drug-Free ROS Sponge Polymeric Microspheres Reduce Tissue Damage from Ischemic and Mechanical Injury. O’Grady KP, Kavanaugh TE, Cho H, Ye H, Gupta MK, Madonna MC, Lee J, O’Brien CM, Skala MC, Hasty KA, Duvall CL. ACS Biomaterials Science & Engineering. 2017 Apr 6. DOI: 10.1021/acsbiomaterials.6b00804
• Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension. Egnatchik RA, Brittain EL, Shah AT, Fares WH, Ford HJ, Monahan K, Kang CJ, Kocurek EG, Zhu S, Luong T, Nguyen TT, Hysinger E, Austin ED, Skala MC, Young JD, Roberts LJ 2nd, Hemnes AR, West J, Fessel JP. Pulm Circ. 2017 Feb 1;7(1):186-199. doi: 10.1086/690236.
• In vivo photothermal optical coherence tomography of endogenous and exogenous contrast agents in the eye. Lapierre-Landry M, Gordon AY, Penn JS, and Skala MC. Scientific Reports 7, Article number: 9228 (2017). doi:10.1038/s41598-017-10050-5
• Functional Optical Imaging of Primary Human Tumor Organoids for Personalized Drug Screens. Walsh AJ, Cook RS, Skala MC. (2017) J Nucl Med. Jun 6. doi: 10.2967/jnumed.117.192534.
• Autofluorescence imaging identifies tumor cell-cycle status on a single-cell level. Heaster TM, Walsh AJ, Zhao Y, Hiebert SW, Skala MC. (2017) J Biophotonics. May 9. doi: 10.1002/jbio.201600276
• Autofluorescence imaging captures heterogeneous drug response differences between 2D and 3D breast cancer cultures. Cannon TM, Shah AT, Skala MC (2017). Biomed. Opt. Express 8, 1911-1925 doi: 10.1364/BOE.8.001911
• Metabolic Imaging of Head and Neck Cancer Organoids. Shah AT, Heaster TM, Skala MC (2017) Metabolic Imaging of Head and Neck Cancer Organoids. PLoS ONE 12(1): e0170415. doi:10.1371/journal.pone.0170415

2016

• Copolymer-mediated cell aggregation promotes a proangiogenic stem cell phenotype in vitro and in vivo. Crowder SW, Balikov DA, Boire TC, McCormack D, Lee JB, Gupta MK, Skala MC, Sung H-J. Adv. Healthcare Mater. 2016 Sep.;  doi: 10.1002/adhm.201600819.
• Autofluorescence flow sorting of breast cancer cell metabolism. Shah AT, Cannon TM, Higginbotham JN, Coffey RJ, Skala MC. J. Biophotonics. 2016 Oct.;  doi: 10.1002/jbio.201600128.
• Depth-resolved analytical model and correction algorithm for photothermal optical coherence tomography.
  Lapierre-Landry M, Tucker-Schwartz JM, Skala MC. Biomedical optics express. 2016; 7(7):2607-22.
• Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response. Walsh AJ, Castellanos JA, Nagathihalli NS, Merchant NB, Skala MC. Pancreas. 2016 Jul;45(6):863-9. doi: 10.1097/MPA.0000000000000543.
• Temporal binning of time-correlated single photon counting data improves exponential decay fits and imaging speed. Walsh AJ, Sharick JT, Skala MC, Beier HT.. Biomedical optics express. 2016; 7(4):1385-99.
• Drug response in organoids generated from frozen primary tumor tissues. Walsh AJ, Cook RS, Sanders ME, Arteaga CL, Skala MC. Sci Rep. 2016 Jan 7;6:18889. doi: 10.1038/srep18889.

2015

• In Vivo Autofluorescence Imaging of Tumor Heterogeneity in Response to Treatment. Shah AT, Diggins KE, Walsh AJ, Irish JM, Skala MC. Neoplasia. 2015 Dec;17(12):862-70. doi: 10.1016/j.neo.2015.11.006.
• Deconvolution of fluorescence lifetime imaging microscopy by a library of exponentials. Campos-Delgado DU, Navarro OG, Arce-Santana ER, Walsh AJ, Skala MC, Jo JA. Opt Express. 2015 Sep 7;23(18):23748-67. doi: 10.1364/OE.23.023748.
• Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer. Nagathihalli NS, Castellanos JA, Shi C, Beesetty Y, Reyzer ML, Caprioli R, Chen X, Walsh AJ, Skala MC, Moses HL, Merchant NB. Gastroenterology. 2015 Dec;149(7):1932-1943.e9. doi: 10.1053/j.gastro.2015.07.058. Epub 2015 Aug 7.
• Blind deconvolution estimation of fluorescence measurements through quadratic programming. Campos-Delgado DU, Gutierrez-Navarro O, Arce-Santana ER, Skala MC, Walsh AJ, Jo JA. J Biomed Opt. 2015 Jul;20(7):075010. doi: 10.1117/1.JBO.20.7.075010.
• Photothermal optical lock-in optical coherence tomography for in vivo imaging. Tucker-Schwartz JM, Lapierre-Landry M, Patil CA, Skala MC. Biomed Opt Express. 2015 May 27;6(6):2268-82. doi: 10.1364/BOE.6.002268. eCollection 2015 Jun 1.
• ROS-responsive microspheres for on demand antioxidant therapy in a model of diabetic peripheral arterial disease. Poole KM, Nelson CE, Joshi RV, Martin JR, Gupta MK, Haws SC, Kavanaugh TE, Skala MC, Duvall CL. Biomaterials. 2015 41:166-75. NIHMSID: NIHMS642415
• Optical metabolic imaging quantifies heterogeneous cell populations. Walsh AJ, Skala MC. >Biomed Opt Express. 2015 Jan 15;6(2):559-73. doi: 10.1364/BOE.6.000559. eCollection 2015 Feb 1.
• Collagen density and alignment in responsive and resistant trastuzumab-treated breast cancer xenografts. Walsh AJ, Cook RS, Lee JH, Arteaga CL, Skala MC. J Biomed Opt. 2015 Feb;20(2):26004. doi: 10.1117/1.JBO.20.2.026004.
• High-throughput measurements of the optical redox ratio using a commercial microplate reader. Cannon TM, Shah AT, Walsh AJ, Skala MC. J Biomed Opt. 2015 Jan;20(1):010503. doi: 10.1117/1.JBO.20.1.010503.

2014

• Uncoupling angiogenesis and inflammation in peripheral artery disease with therapeutic peptide-loaded microgels.
  Zachman AL, Wang X, Tucker-Schwartz JM, Fitzpatrick ST, Lee SH, Guelcher SA, Skala MC, Sung HJ. Biomaterials. 2014; 35(36):9635-48. NIHMSID: NIHMS624426
• Quantifying the vascular response to ischemia with speckle variance optical coherence tomography. Poole KM, McCormack DR, Patil CA, Duvall CL, Skala MC. Biomedical optics express. 2014; 5(12):4118-30.
• Quantitative optical imaging of primary tumor organoid metabolism predicts drug response in breast cancer.
  Walsh AJ, Cook RS, Sanders ME, Aurisicchio L, Ciliberto G, Arteaga CL, Skala MC. Cancer research. 2014; 74(18):5184-94. NIHMSID: NIHMS617855
• In vivo hyperspectral imaging of microvessel response to trastuzumab treatment in breast cancer xenografts. McCormack DR, Walsh AJ, Sit W, Arteaga CL, Chen J, Cook RS, Skala MC. Biomedical optics express. 2014; 5(7):2247-61.
• In vivo imaging of nanoparticle delivery and tumor microvasculature with multimodal optical coherence tomography. Tucker-Schwartz JM, Beavers KR, Sit WW, Shah AT, Duvall CL, Skala MC. Biomedical optics express. 2014; 5(6):1731-43.
• The NADH oxidase ENOX1, a critical mediator of endothelial cell radiosensitization, is crucial for vascular development. Venkateswaran A, Sekhar KR, Levic DS, Melville DB, Clark TA, Rybski WM, Walsh AJ, Skala MC, Crooks PA, Knapik EW, Freeman ML. Cancer research. 2014; 74(1):38-43. NIHMSID: NIHMS543105
• Optical metabolic imaging of treatment response in human head and neck squamous cell carcinoma. Shah AT, Demory Beckler M, Walsh AJ, Jones WP, Pohlmann PR, Skala MC. PloS one. PloS one. 2014; 9(3):e90746.

2013

• Quantitative optical imaging of vascular response in vivo in a model of peripheral arterial disease. Poole KM, Tucker-Schwartz JM, Sit WW, Walsh AJ, Duvall CL, Skala MC. American journal of physiology. Heart and circulatory physiology. 2013; 305(8):H1168-80.
• Optical metabolic imaging identifies glycolytic levels, subtypes, and early-treatment response in breast cancer. Walsh AJ, Cook RS, Manning HC, Hicks DJ, Lafontant A, Arteaga CL, Skala MC. Cancer research. 2013; 73(20):6164-74. NIHMSID: NIHMS515760
• The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins. Venkateswaran A, Friedman DB, Walsh AJ, Skala MC, Sasi S, Rachakonda G, Crooks PA, Freeman ML, Sekhar KR. Investigational new drugs. 2013; 31(3):535-44. NIHMSID: NIHMS413695
• Cross-sectional tracking of particle motion in evaporating drops: flow fields and interfacial accumulation. Trantum JR, Eagleton ZE, Patil CA, Tucker-Schwartz JM, Baglia ML, Skala MC, Haselton FR. Langmuir : the ACS journal of surfaces and colloids.. 2013; 29(21):6221-31. NIHMSID: NIHMS792311
• Dual pH- and temperature-responsive microparticles for protein delivery to ischemic tissues. Joshi RV, Nelson CE, Poole KM, Skala MC, Duvall CL. Acta biomaterialia.. 2013; 9(5):6526-34. NIHMSID: NIHMS445461
• Three-dimensional molecular imaging with photothermal optical coherence tomography. Skala MC, Crow MJ, Wax A, Izatt JA. Methods in molecular biology. 2013; 1026:85-92. NIHMSID: NIHMS697574

2012

• In vivo photothermal optical coherence tomography of gold nanorod contrast agents. Tucker-Schwartz JM, Meyer TA, Patil CA, Duvall CL, Skala MC. Biomedical optics express. 2012; 3(11):2881-95.
• Ex vivo optical metabolic measurements from cultured tissue reflect in vivo tissue status. Walsh AJ, Poole KM, Duvall CL, Skala MC. Journal of biomedical optics. 2012; 17(11):116015.
• Dual-modality photothermal optical coherence tomography and magnetic-resonance imaging of carbon nanotubes. Tucker-Schwartz JM, Hong T, Colvin DC, Xu Y, Skala MC. Optics letters. 2012; 37(5):872-4. NIHMSID: NIHMS388212
• Optical imaging of metabolism in HER2 overexpressing breast cancer cells. Walsh A, Cook RS, Rexer B, Arteaga CL, Skala MC. Biomedical optics express. 2012; 3(1):75-85.

2004 – 2011

• Longitudinal optical imaging of tumor metabolism and hemodynamics. Skala MC, Fontanella A, Lan L, Izatt JA, Dewhirst MW. Journal of biomedical optics. 2010; 15(1):011112.
• Multiphoton redox ratio imaging for metabolic monitoring in vivo. Skala M, Ramanujam N. Methods in molecular biology. 2010; 594:155-62. NIHMSID: NIHMS201646
• Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging. Skala MC, Fontanella A, Hendargo H, Dewhirst MW, Izatt JA. Optics letters. 2009; 34(3):289-91. NIHMSID: NIHMS122921
• Photothermal optical coherence tomography of epidermal growth factor receptor in live cells using immunotargeted gold nanospheres. Skala MC, Crow MJ, Wax A, Izatt JA. Nano letters. 2008; 8(10):3461-7. NIHMSID: NIHMS68839
• In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia. Skala MC, Riching KM, Gendron-Fitzpatrick A, Eickhoff J, Eliceiri KW, White JG, Ramanujam N. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(49):19494-9.
• Comparison of a physical model and principal component analysis for the diagnosis of epithelial neoplasias in vivo using diffuse reflectance spectroscopy. Skala MC, Palmer GM, Vrotsos KM, Gendron-Fitzpatrick A, Ramanujam N. Optics express. 2007; 15(12):7863-75. NIHMSID: NIHMS24764
• In vivo multiphoton fluorescence lifetime imaging of protein-bound and free nicotinamide adenine dinucleotide in normal and precancerous epithelia. Skala MC, Riching KM, Bird DK, Gendron-Fitzpatrick A, Eickhoff J, Eliceiri KW, Keely PJ, Ramanujam N. Journal of biomedical optics. 2007; 12(2):024014. NIHMSID: NIHMS122928
• Multiphoton microscopy of endogenous fluorescence differentiates normal, precancerous, and cancerous squamous epithelial tissues. Skala MC, Squirrell JM, Vrotsos KM, Eickhoff JC, Gendron-Fitzpatrick A, Eliceiri KW, Ramanujam N. Cancer research. 2005; 65(4):1180-6. NIHMSID: NIHMS485459
• Investigation of fiber-optic probe designs for optical spectroscopic diagnosis of epithelial pre-cancers.
  Skala MC, Palmer GM, Zhu C, Liu Q, Vrotsos KM, Marshek-Stone CL, Gendron-Fitzpatrick A, Ramanujam N. Lasers in surgery and medicine. 2004; 34(1):25-38. NIHMSID: NIHMS122929